Abstract: A method for preparing a labeling agent includes: providing a compound including a chelating moiety and a conjugation moiety; contacting the compound with a radionuclide to create a radiolabeled preparation having a first molar activity; and purifying the radiolabeled preparation to prepare a labeling agent having a second molar activity that is greater than the first molar activity. A biological material can be contacted with a labeling agent prepared by the method such that the biological material becomes labeled for imaging. In one example embodiment, there is provided a way of synthesizing a labeling agent, such as 89Zr-labeled p-isothiocyana to-benzyl-desferrioxamine, using a purification step that results in increased molar activity and labeling efficiency, which makes possible the successful labeling of biological materials at very low concentrations where an unpurified labeling agent would be unsuccessful.

Abstract: Disclosed are compounds of formula (1), formula (2), formula (75), formula (80) and formula (90): wherein R1, R2, R3, R4, and R5 can be selected from the group consisting of hydrogen, unsubstituted alkyl, substituted alkyl, unsubstituted haloalkyl, substituted haloalkyl, unsubstituted hydroxyalkyl, substituted hydroxyalkyl, benzyl, phenyl, substituted phenyl, unsubstituted alkenyl, substituted alkenyl, unsubstituted cycloalkyl, substituted cycloalkyl, hydroxy, unsubstituted alkoxy, substituted alkoxy, unsubstituted haloalkoxy, substituted haloalkoxy, unsubstituted phenoxy, substituted phenoxy, unsubstituted sulfonyloxy, substituted sulfonyloxy, carbonyl, carboxy, unsubstituted amino, substituted amino, unsubstituted amido, and substituted amido, and wherein at least one atom in R1 is replaced with a positron emitter. Also disclosed are methods for in vivo imaging of a subject using the compound of formula (1) or formula (2) or formula (75) or formula (80) or formula (90).

Abstract: A computer-based method is provided for evaluating risk for workers. The method includes receiving, at a processor, a first signal from a first wearable device. The first signal is received from a first wearable device and is indicative of vertical acceleration detected by the first wearable device over time. The method then identifies, in the first signal, an indication of weightlessness at the first wearable device. Upon detecting the indication of weightlessness, the method proceeds to determine an amount of time associated with the indication of weightlessness and then determines a risk metric associated with the indication of weightlessness based on the amount of time associated with the indication of weightlessness.

Abstract: A method for chemically induced homing of extracellular vesicles (EVs) to a specific tissue or organ in a subject for either treatment or diagnosis of a medical condition, the method comprising administering to the subject an amount of a homing agent. The homing agent is at least one of a derivative of polyethylene glycol), or a derivative of phenothiazine;. The EVs are homed to the homing agent in the subject.

Abstract: Methods of ex vivo labeling of a biological material for in vivo imaging, methods of labeling a biological material in vivo, methods for preparing a labeling agent, and methods for in vivo imaging of a subject using a biological material labeled with a labeling agent are disclosed. In one non-limiting example, the biological material is selected from cells and the labeling agent is a 89Zr-Desferrioxamine-NCS labeling agent.

Abstract: A method for chemically induced homing of extracellular vesicles (EVs) to a specific tissue or organ in a subject for either treatment or diagnosis of a medical condition, the method comprising administering to the subject an amount of a homing agent. The homing agent is at least one of a derivative of poly(ethylene glycol), or a derivative of phenothiazine. The EVs are homed to the homing agent in the subject.

Abstract: Methods and systems for monitoring workplace safety and evaluating risks is provided, the method comprising receiving signals from at least one wearable device, identifying portions of the signals corresponding to physical activities, excerpting the portions of the signals corresponding to the physical activities, and calculating risk metrics based on measurements extracted from the excerpted portions of the signals, the risk metric indicative of high risk lifting activities.

Abstract: Methods and systems for monitoring workplace safety and evaluating risks is provided, the method comprising receiving signals from at least one wearable device, identifying portions of the signals corresponding to physical activities, excerpting the portions of the signals corresponding to the physical activities, and calculating risk metrics based on measurements extracted from the excerpted portions of the signals, the risk metric indicative of high risk lifting activities.

Abstract: Methods of ex vivo labeling of a biological material for in vivo imaging, methods of labeling a biological material in vivo, methods for preparing a labeling agent, and methods for in vivo imaging of a subject using a biological material labeled with a labeling agent are disclosed. In one non-limiting example, the biological material is selected from cells and the labeling agent is a 89Zr-Desferrioxamine-NCS labeling agent.

Abstract: A method for chemically induced homing of extracellular vesicles (EVs) to a specific tissue or organ in a subject for either treatment or diagnosis of a medical condition, the method comprising administering to the subject an amount of a homing agent. The homing agent is at least one of a derivative of poly(ethylene glycol), or a derivative of phenothiazine. The EVs are homed to the homing agent in the subject.

Abstract: Methods and systems for monitoring workplace safety and evaluating risks is provided, the method comprising receiving signals from at least one wearable device, identifying portions of the signals corresponding to physical activities, excerpting the portions of the signals corresponding to the physical activities, and calculating risk metrics based on measurements extracted from the excerpted portions of the signals, the risk metric indicative of high risk lifting activities.

Abstract: Methods and systems for monitoring workplace safety and evaluating risks is provided, the method comprising receiving signals from at least one wearable device, identifying portions of the signals corresponding to physical activities, excerpting the portions of the signals corresponding to the physical activities, and calculating risk metrics based on measurements extracted from the excerpted portions of the signals, the risk metric indicative of high risk lifting activities.

Abstract: Methods and systems for monitoring workplace safety and evaluating risks is provided, the method comprising receiving signals from at least one wearable device, identifying portions of the signals corresponding to physical activities, excerpting the portions of the signals corresponding to the physical activities, and calculating risk metrics based on measurements extracted from the excerpted portions of the signals, the risk metric indicative of high risk lifting activities.

Abstract: Methods and systems for monitoring workplace safety and evaluating risks is provided, the method comprising receiving signals from at least one wearable device, identifying portions of the signals corresponding to physical activities, excerpting the portions of the signals corresponding to the physical activities, and calculating risk metrics based on measurements extracted from the excerpted portions of the signals, the risk metric indicative of high risk lifting activities.

Abstract: A glucose sensor comprises a conducting back electrode. The glucose sensor also comprises a silicon substrate in electrical contact with the conducting back electrode. The glucose sensor also comprises a dielectric layer disposed on the silicon substrate. The glucose sensor also comprises a pH sensing layer disposed on the dielectric layer. The glucose sensor also comprises a chemical layer disposed on the pH sensing layer, wherein the chemical layer is in contact with an aqueous solution. The glucose sensor also comprises a conductive electrode disposed on the dielectric layer, where in the conductive electrode is in contact with the aqueous solution.

Abstract: Methods of ex vivo labeling of a biological material for in vivo imaging, methods of labeling a biological material in vivo, methods for preparing a labeling agent, and methods for in vivo imaging of a subject using a biological material labeled with a labeling agent are disclosed. In one non-limiting example, the biological material is selected from cells and the labeling agent is a 89Zr-Desferrioxamine-NCS labeling agent.

Abstract: A method for monitoring workplace safety and evaluating risks during lifting activities is provided, the method comprising receiving signals from wearable first and second devices, identifying portions of the signals corresponding to lifting activities, excerpting the portions of the signals corresponding to lifting activities, and calculating risk metrics based on measurements extracted from the excerpted portions of the signals, the risk metric indicative of high risk lifting activities.

Abstract: A method for monitoring workplace safety and evaluating risks during lifting activities is provided, the method comprising receiving signals from wearable first and second devices, identifying portions of the signals corresponding to lifting activities, excerpting the portions of the signals corresponding to lifting activities, and calculating risk metrics based on measurements extracted from the excerpted portions of the signals, the risk metric indicative of high risk lifting activities.

Abstract: Methods and systems for monitoring workplace safety and evaluating risks is provided, the method comprising receiving signals from at least one wearable device, identifying portions of the signals corresponding to physical activities, excerpting the portions of the signals corresponding to the physical activities, and calculating risk metrics based on measurements extracted from the excerpted portions of the signals, the risk metric indicative of high risk lifting activities.

Abstract: A clock driver is provided. The clock driver includes a multi-stage delay cell having an input, a positive pulse driving branch, a negative pulse driving branch, and an output. The input is for receiving an original version of a reference clock signal input to the clock driver and used to generate a global clock signal. The output is connected to the positive pulse driving branch and the negative pulse driving branch. The clock driver further includes a pulse generator having positive and negative pulse generator portions respectively connected to outputs of the positive and negative pulse driving branches. The pulse generator generates, at any given time, one of a positive pulse and a negative pulse responsive to a positive pulse enable signal and a negative pulse enable signal, respectively, and the original version of the reference clock signal input to the clock driver without modification.