Patents by Inventor Aditya Kashyap
Aditya Kashyap has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 11515009Abstract: Embodiments of the invention relate to a computer-implemented method for quantifying a biomarker in a tissue sample of an organism. An image analysis system receives images of a stained tissue sample. Each received digital image depicts the tissue sample region at the end of an exposure interval. The system analyzes the intensity values and exposure intervals of the received digital images for determining the time when the intensity values corresponding to the plurality of exposure intervals ordered according to ascending exposure interval lengths reach a plateau (saturation residence time—SRT). The system determines the amount of a biomarker in the tissue sample and/or predicts a tumor stage and/or a treatment recommendation as a function of the SRT.Type: GrantFiled: March 19, 2018Date of Patent: November 29, 2022Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATIONInventors: Govind Kaigala, Anna Fomitcheva Khartchenko, Aditya Kashyap, Maria Gabrani, Pushpak Pati
-
Patent number: 11208648Abstract: Techniques regarding measuring a position and transcriptome of one or more cells from a biological sample are provided. For example, one or more embodiments described herein can comprise a method, which can comprise covalently bonding a probe to a molecular structure located on a cell to label the cell according to a position of the cell with regards to a biological sample comprising the cell. The probe comprises an oligonucleotide sequence that can be indicative of the position.Type: GrantFiled: November 16, 2018Date of Patent: December 28, 2021Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATIONInventors: Robert Vogel, Navneet Dogra, Lena Voith von Voithenberg, Aditya Kashyap, Govind V. Kaigala, Gustavo Alejandro Stolovitzky
-
Patent number: 10706535Abstract: The invention relates to the automated determination of the staining quality of an IHC stained biological sample. A plurality of features is extracted from a digital IHC stained tissue image. The features are input into a first classifier configured to identify the extended tissue type of the depicted tissue as a function of the extracted features. An extended tissue type is a tissue type with a defined expression level of the tumor marker. In addition, the extracted features are input into a second classifier configured to identify a contrast level of the depicted tissue as a function of at least some second ones of the extracted features. The contrast level indicates the intensity contrast of pixels of the stained tissue. Then, a staining quality score of the image is computed as a function of the identified extended tissue type and the identified contrast level.Type: GrantFiled: September 8, 2017Date of Patent: July 7, 2020Assignee: International Business Machines CorporationInventors: Nuri Murat Arar, Maria Gabrani, Govind Kaigala, Aditya Kashyap, Anna Fomitcheva Khartchenko, Pushpak Pati
-
Publication number: 20200157528Abstract: Techniques regarding measuring a position and transcriptome of one or more cells from a biological sample are provided. For example, one or more embodiments described herein can comprise a method, which can comprise covalently bonding a probe to a molecular structure located on a cell to label the cell according to a position of the cell with regards to a biological sample comprising the cell. The probe comprises an oligonucleotide sequence that can be indicative of the position.Type: ApplicationFiled: November 16, 2018Publication date: May 21, 2020Inventors: Robert Vogel, Navneet Dogra, Lena Voith von Voithenberg, Aditya Kashyap, Govind V. Kaigala, Gustavo Alejandro Stolovitzky
-
Patent number: 10549276Abstract: A microfluidic probe head for providing a sequence of separate liquid volumes separated by spacers, the separate liquid volumes including a respective target substance associated with a respective target area, the microfluidic probe head including an inlet and an outlet; a first fluid channel fluidly connected to the inlet, the first fluid channel configured for delivering an injection liquid from the inlet to a respective target area; a second fluid channel fluidly connected to the outlet, the second fluid channel configured for delivering liquid volumes from the respective target area to the outlet; and a spacer insertion unit fluidly connected to the second fluid channel, the spacer insertion unit configured for inserting spacers into the second fluid channel between the liquid volumes to provide the sequence of separate liquid volumes separated by spacers.Type: GrantFiled: July 23, 2019Date of Patent: February 4, 2020Assignee: International Business Machines CorporationInventors: Julien Autebert, Emmanuel Delamarche, Govind Kaigala, Aditya Kashyap, Xander Frank Van Kooten
-
Publication number: 20190344268Abstract: A microfluidic probe head for providing a sequence of separate liquid volumes separated by spacers, the separate liquid volumes including a respective target substance associated with a respective target area, the microfluidic probe head including an inlet and an outlet; a first fluid channel fluidly connected to the inlet, the first fluid channel configured for delivering an injection liquid from the inlet to a respective target area; a second fluid channel fluidly connected to the outlet, the second fluid channel configured for delivering liquid volumes from the respective target area to the outlet; and a spacer insertion unit fluidly connected to the second fluid channel, the spacer insertion unit configured for inserting spacers into the second fluid channel between the liquid volumes to provide the sequence of separate liquid volumes separated by spacers.Type: ApplicationFiled: July 23, 2019Publication date: November 14, 2019Inventors: Julien Autebert, Emmanuel Delamarche, Govind Kaigala, Aditya Kashyap, Xander Frank Van Kooten
-
Publication number: 20190286790Abstract: Embodiments of the invention relate to a computer-implemented method for quantifying a biomarker in a tissue sample of an organism. An image analysis system receives images of a stained tissue sample. Each received digital image depicts the tissue sample region at the end of an exposure interval. The system analyzes the intensity values and exposure intervals of the received digital images for determining the time when the intensity values corresponding to the plurality of exposure intervals ordered according to ascending exposure interval lengths reach a plateau (saturation residence time—SRT). The system determines the amount of a biomarker in the tissue sample and/or predicts a tumor stage and/or a treatment recommendation as a function of the SRT.Type: ApplicationFiled: March 19, 2018Publication date: September 19, 2019Inventors: Govind Kaigala, Anna Fomitcheva Khartchenko, Aditya Kashyap, Maria Gabrani, Pushpak Pati
-
Patent number: 10391488Abstract: A microfluidic probe head for providing a sequence of separate liquid volumes separated by spacers, the separate liquid volumes including a respective target substance associated with a respective target area, the microfluidic probe head including an inlet and an outlet; a first fluid channel fluidly connected to the inlet, the first fluid channel configured for delivering an injection liquid from the inlet to a respective target area; a second fluid channel fluidly connected to the outlet, the second fluid channel configured for delivering liquid volumes from the respective target area to the outlet; and a spacer insertion unit fluidly connected to the second fluid channel, the spacer insertion unit configured for inserting spacers into the second fluid channel between the liquid volumes to provide the sequence of separate liquid volumes separated by spacers.Type: GrantFiled: February 11, 2016Date of Patent: August 27, 2019Assignee: International Business Machines CorporationInventors: Julien Autebert, Emmanuel Delamarche, Govind Kaigala, Aditya Kashyap, Xander Frank Van Kooten
-
Publication number: 20190080450Abstract: The invention relates to the automated determination of the staining quality of an IHC stained biological sample. A plurality of features is extracted from a digital IHC stained tissue image. The features are input into a first classifier configured to identify the extended tissue type of the depicted tissue as a function of the extracted features. An extended tissue type is a tissue type with a defined expression level of the tumor marker. In addition, the extracted features are input into a second classifier configured to identify a contrast level of the depicted tissue as a function of at least some second ones of the extracted features. The contrast level indicates the intensity contrast of pixels of the stained tissue. Then, a staining quality score of the image is computed as a function of the identified extended tissue type and the identified contrast level.Type: ApplicationFiled: September 8, 2017Publication date: March 14, 2019Inventors: Nuri Murat Arar, Maria Gabrani, Govind Kaigala, Aditya Kashyap, Anna Fomitcheva Khartchenko, Pushpak Pati
-
Publication number: 20160236194Abstract: A microfluidic probe head for providing a sequence of separate liquid volumes separated by spacers, the separate liquid volumes including a respective target substance associated with a respective target area, the microfluidic probe head including an inlet and an outlet; a first fluid channel fluidly connected to the inlet, the first fluid channel configured for delivering an injection liquid from the inlet to a respective target area; a second fluid channel fluidly connected to the outlet, the second fluid channel configured for delivering liquid volumes from the respective target area to the outlet; and a spacer insertion unit fluidly connected to the second fluid channel, the spacer insertion unit configured for inserting spacers into the second fluid channel between the liquid volumes to provide the sequence of separate liquid volumes separated by spacers.Type: ApplicationFiled: February 11, 2016Publication date: August 18, 2016Inventors: Julien Autebert, Emmanuel Delamarche, Govind Kaigala, Aditya Kashyap, Xander Frank Van Kooten
-
Publication number: 20140155141Abstract: A method of selecting players to make payments associated with a session of a game is disclosed. A player is selected to make a payment. The selecting of the player is based on a session counter of the player having a higher value than a session counter of an additional player seeking to participate in the session of the game. Based on a receiving of the payment from the selected player, the session counter of the selected player is decremented by an amount corresponding to the payment, the value of the session counter of the additional player is incremented by an amount corresponding to the payment, and the selected player and the unselected player are allowed to participate in the session of the instance of the game.Type: ApplicationFiled: November 27, 2013Publication date: June 5, 2014Applicant: Zynga Inc.Inventors: Aditya Kashyap, Laura Louise Dansingani, Kenton Kivestu, Hohyun Shim, Xingxing Xu, Alex Leffelman, Jacky Ho