Patents by Inventor Aditya Krishnan Unni

Aditya Krishnan Unni has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SUBSTITUTED 1,2-DIHYDRO-3H-PYRAZOLO[3,4-D]PYRIMIDIN-3-ONES
    Publication number: 20240391924
    Abstract: Compounds of Formula (I) are provided herein. Such compounds, as well as pharmaceutically acceptable salts and compositions thereof, are useful for treating diseases or conditions, including conditions characterized by excessive cellular proliferation, such as breast cancer.
    Type: Application
    Filed: August 2, 2024
    Publication date: November 28, 2024
    Inventors: Peter Qinhua Huang, Kevin Duane Bunker, Brant Clayton Boren, Sayee Gajanan Hegde, Hui Liu, Aditya Krishnan Unni, Sunny Abraham, Chad Daniel Hopkins, Sunil Paliwal
  • Process for making [1.1.1]propellane
    Patent number: 11724971
    Abstract: Processes of making [1.1.1]propellane utilize reaction conditions that include reacting 1,1-dibromo-2,2-bis(chloromethyl)cyclopropane with an effective amount of solid magnesium.
    Type: Grant
    Filed: August 12, 2020
    Date of Patent: August 15, 2023
    Assignee: Recurium IP Holdings, LLC
    Inventors: Aditya Krishnan Unni, Joseph Robert Pinchman, Peter Qinhua Huang, Kevin Duane Bunker
  • PREPARATION OF AN SELECTIVE ESTROGEN RECEPTOR DEGRADER
    Publication number: 20230212118
    Abstract: Described herein is a method for obtaining a selective estrogen receptor degrader, and compounds used in preparing the selective estrogen receptor degrader.
    Type: Application
    Filed: April 21, 2021
    Publication date: July 6, 2023
    Inventors: Peter Qinhua Huang, Sayee Gajanan Hegde, Kevin Duane Bunker, John Knight, Joseph Robert Pinchman, Aditya Krishnan Unni, Rakesh Kumar Sit, Shuguang Zhu, Chad Daniel Hopkins, Ian Scott
  • DIFLUOROMETHYL IODO COMPOUNDS AND METHODS
    Publication number: 20230159416
    Abstract: The present application is related to an improved process for synthesising 1-(difluoromethyl)-3-iodobicyclo[1.1.1]pentane from difluoromethyl iodide and [1.1.1]propellane. Difluoromethyl iodide is made by reacting an iodide salt with chlorodifluoroacetic acid in the presence of a solvent such as sulfolane and an inorganic base, [1.1.1]propellane is synthesised by reacting 1,1-dibromo-2,2-cis(chloromethyl)cyclopropane with a reagent such as magnesium, methyllithium or phenyllithium.
    Type: Application
    Filed: February 17, 2021
    Publication date: May 25, 2023
    Inventors: Aditya Krishnan Unni, Joseph Robert Pinchman, Peter Qinhua Huang, Kevin Duane Bunker
  • CHIRAL SYNTHESIS OF A TERTIARY ALCOHOL
    Publication number: 20230002426
    Abstract: Disclosed herein are methods for preparing tertiary alcohols from an optionally substituted phenyl ketone or an optionally substituted pyridinyl ketone that includes the use of a chiral ligand and boron trifluoride diethyl etherate. Tertiary alcohols can be used to prepare synthetic versions of natural products and/or pharmaceuticals.
    Type: Application
    Filed: November 12, 2020
    Publication date: January 5, 2023
    Inventors: Sunny Abraham, Brant Clayton Boren, Sobhana Babu Boga, Aditya Krishnan Unni, Peter Qinhua Huang, Kevin Duane Bunker, Benjamin Anthony Pratt
  • PROCESS FOR MAKING [1.1.1]PROPELLANE
    Publication number: 20220324775
    Abstract: Processes of making [1.1.1]propellane utilize reaction conditions that include reacting 1,1-dibromo-2,2-bis(chloromethyl)cyclopropane with an effective amount of solid magnesium.
    Type: Application
    Filed: August 12, 2020
    Publication date: October 13, 2022
    Inventors: Aditya Krishnan Unni, Joseph Robert Pinchman, Peter Qinhua Huang, Kevin Duane Bunker
  • NANOPARTICLE FORMULATION OF BCL-2 INHIBITOR
    Publication number: 20220273666
    Abstract: Various albumin nanoparticle Bcl-2 inhibitor formulations are described, along with methods of using them to treat conditions characterized by excessive cellular proliferation, such as cancer and tumors. In various embodiments, such Bcl-2 inhibitor formulations contain albumin and a compound of the following Formula (I), or a pharmaceutically acceptable salt thereof, where the variables in Formula (I) are defined herein.
    Type: Application
    Filed: July 8, 2020
    Publication date: September 1, 2022
    Inventors: Joseph Robert Pinchman, Aditya Krishnan Unni, Yosef Shamay, Kevin Duane Bunker, Peter Qinhua Huang
  • Substituted 1,2-dihydro-3H-pyrazolo[3,4-D]pyrimidin-3-ones
    Patent number: 11261192
    Abstract: Compounds of Formula (I) are provided herein. Such compounds, as well as pharmaceutically acceptable salts and compositions thereof, are useful for treating diseases or conditions, including conditions characterized by excessive cellular proliferation, such as breast cancer.
    Type: Grant
    Filed: February 26, 2019
    Date of Patent: March 1, 2022
    Assignee: Recurium IP Holdings, LLC
    Inventors: Peter Qinhua Huang, Kevin Duane Bunker, Brant Clayton Boren, Sayee Gajanan Hegde, Hui Liu, Aditya Krishnan Unni, Sunny Abraham, Chad Daniel Hopkins, Sunil Paliwal
  • SUBSTITUTED 1,2-DIHYDRO-3H-PYRAZOLO[3,4-D]PYRIMIDIN-3-ONES
    Publication number: 20220024939
    Abstract: Compounds of Formula (I) are provided herein. Such compounds, as well as pharmaceutically acceptable salts and compositions thereof, are useful for treating diseases or conditions, including conditions characterized by excessive cellular proliferation, such as breast cancer.
    Type: Application
    Filed: October 8, 2021
    Publication date: January 27, 2022
    Inventors: Peter Qinhua Huang, Kevin Duane Bunker, Brant Clayton Boren, Sayee Gajanan Hegde, Hui Liu, Aditya Krishnan Unni, Sunny Abraham, Chad Daniel Hopkins, Sunil Paliwal
  • SUBSTITUTED 1,2-DIHYDRO-3H-PYRAZOLO[3,4-D]PYRIMIDIN-3-ONES
    Publication number: 20210139482
    Abstract: Compounds of Formula (I) are provided herein. Such compounds, as well as pharmaceutically acceptable salts and compositions thereof, are useful for treating diseases or conditions, including conditions characterized by excessive cellular proliferation, such as breast cancer.
    Type: Application
    Filed: February 26, 2019
    Publication date: May 13, 2021
    Inventors: Peter Qinhua Huang, Kevin Duane Bunker, Brant Clayton Boren, Sayee Gajanan Hegde, Hui Liu, Aditya Krishnan Unni, Sunny Abraham, Chad Daniel Hopkins, Sunil Paliwal