Abstract: A system for generating a 4D representation of a scene in motion given a sinogram collected from the scene while in motion. The system generates, based on scene parameters, an initial 3D representation of the scene indicating linear attenuation coefficients (LACs) of voxels of the scene. The system generates, based on motion parameters, a 4D motion field indicating motion of the scene. The system generates, based on the initial 3D representation and the 4D motion field, a 4D representation of the scene that is a sequence of 3D representations having LACs. The system generates a synthesized sinogram of the scene from the generated 4D representation. The system adjusts the scene parameters and the motion parameters based on differences between the collected sinogram and the synthesized sinogram. The processing is repeated until the differences satisfy a termination criterion.

Abstract: The invention features compositions and methods for treating and preventing cancer. In one aspect, isolated fusion proteins are provided that comprise a DNAJBI portion and a PRKACA portion. In a further aspect, compositions are provided, including immunogenic compositions that comprise an isolated fusion protein comprising a DNAJBI portion and a PRKACA portion. In a yet further aspect, a cancer vaccine is provided that comprises an isolated fusion protein comprising a DNAJBI portion and a PRKACA portion.

Abstract: The disclosure provides methods of making a protein having a desired non-standard amino acid incorporated at its N-terminus in a cell and methods of screening for an amino acyl tRNA synthetase variant that preferentially selects a non-standard amino acid against its standard amino acid counterpart or undesired non-standard amino acids for incorporation into a protein in a cell.

Abstract: A system for generating a 3D segmentation of a target volume is provided. The system accesses views of an X-ray scan of a target volume. The system applies a 2D CNN to each view to generate a 2D multi-channel feature vector for each view. The system applies a space carver to generate a 3D channel volume for each channel based on the 2D multi-channel feature vectors. The system then applies a linear combining technique to the 3D channel volumes to generate a 3D multi-label map that represents a 3D segmentation of the target volume.

Abstract: The present disclosure relates to ultra-pure forms, polymorphs, amorphous forms, and formulations of N-[(1r,4r)-4-(3-chloro-4-cyanophenoxy)cyclohexyl]-6-[4-({4-[2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl]piperazin-1-yl}methyl)piperidin-1-yl]pyridazine-3-carboxamide, referred to herein as Compound A: The present disclosure also relates methods of manufacturing and purifying the same, as well as intermediates useful in the synthesis of Compound A. The ultra-pure forms, polymorphs, amorphous forms, and formulations of Compound A can be used as therapeutic agents for the treatment of various diseases and conditions such as cancer.

Abstract: A system for generating a 4D representation of a scene in motion given a sinogram collected from the scene while in motion. The system generates, based on scene parameters, an initial 3D representation of the scene indicating linear attenuation coefficients (LACs) of voxels of the scene. The system generates, based on motion parameters, a 4D motion field indicating motion of the scene. The system generates, based on the initial 3D representation and the 4D motion field, a 4D representation of the scene that is a sequence of 3D representations having LACs. The system generates a synthesized sinogram of the scene from the generated 4D representation. The system adjusts the scene parameters and the motion parameters based on differences between the collected sinogram and the synthesized sinogram. The processing is repeated until the differences satisfy a termination criterion.

Abstract: Exemplary embodiments of the present disclosure are directed towards an implantable device for complete replacement of temporomandibular joint comprising of a condyle component to reconstruct a mandibular end of the temporomandibular joint designed for movement within the implantable device with a plate; and a condyle surface where the plate is configured to mechanically secure the condyle component to a ramus surface of a patient undergoing implant with the aid of screws; and the condyle surface polished to generate a mirror effect to reduce the friction in the implantable device and infection rate; a zygomatic arch component to reconstruct a temporal bone (glenoid fossa) of the temporomandibular joint comprising at least one of: a plate; a plurality of multiple threaded counter sink holes; a plurality of conically tapered holes and a zygomatic arch surface, whereby the multiple threaded counter sink holes are structured within the plate; and a fossa component configured to be positioned between the condyle

Abstract: A method and system are provided for adaptive evaluation of meta-relationships in semantic graphs. The method includes providing a semantic graph based on a knowledge base in which concepts in the form of graph nodes are linked by semantic relationships in the form of graph edges. Metadata are encoded in the edges and nodes of the semantic graph, of weightings for measuring a meta-relationship, wherein the meta-relationship applies to the concepts of the semantic graph and is independent of the semantic relationship defined by the edges of the semantic graph. A graph activation is carried out for an input context relating to one or more concepts of the semantic graph, wherein the weightings are applied to a spreading activation signal through the semantic graph to produce a measure of the meta-relationship for a sub-set of concepts of the semantic graph.

Abstract: A method and system are provided for adaptive evaluation of meta-relationships in semantic graphs. The method includes providing a semantic graph based on a knowledge base in which concepts in the form of graph nodes are linked by semantic relationships in the form of graph edges. Metadata are encoded in the edges and nodes of the semantic graph, of weightings for measuring a meta-relationship, wherein the meta-relationship applies to the concepts of the semantic graph and is independent of the semantic relationship defined by the edges of the semantic graph. A graph activation is carried out for an input context relating to one or more concepts of the semantic graph, wherein the weightings are applied to a spreading activation signal through the semantic graph to produce a measure of the meta-relationship for a sub-set of concepts of the semantic graph.

Abstract: A system for generating a 3D segmentation of a target volume is provided. The system accesses views of an X-ray scan of a target volume. The system applies a 2D CNN to each view to generate a 2D multi-channel feature vector for each view. The system applies a space carver to generate a 3D channel volume for each channel based on the 2D multi-channel feature vectors. The system then applies a linear combining technique to the 3D channel volumes to generate a 3D multi-label map that represents a 3D segmentation of the target volume.

Abstract: The disclosure provides methods of making a protein having a desired non-standard amino acid incorporated at its N-terminus in a cell and methods of screening for an amino acyl tRNA synthetase variant that preferentially selects a non-standard amino acid against its standard amino acid counterpart or undesired non-standard amino acids for incorporation into a protein in a cell.

Abstract: Exemplary embodiments of the present disclosure are directed towards an implantable device for complete replacement of temporomandibular joint comprising of a condyle component to reconstruct a mandibular end of the temporomandibular joint designed for movement within the implantable device with a plate; and a condyle surface where the plate is configured to mechanically secure the condyle component to a ramus surface of a patient undergoing implant with the aid of screws; and the condyle surface polished to generate a mirror effect to reduce the friction in the implantable device and infection rate; a zygomatic arch component to reconstruct a temporal bone (glenoid fossa) of the temporomandibular joint comprising at least one of: a plate; a plurality of multiple threaded counter sink holes; a plurality of conically tapered holes and a zygomatic arch surface, whereby the multiple threaded counter sink holes are structured within the plate; and a fossa component configured to be positioned between the condyle

Abstract: Method and system are provided for adaptive evaluation of meta-relationships in semantic graphs. The method includes providing a semantic graph based on a knowledge base in which concepts in the form of graph nodes are linked by semantic relationships in the form of graph edges. Metadata is encoded in the edges and nodes of the semantic graph, of weightings for measuring a meta-relationship, wherein the meta-relationship applies to the concepts of the semantic graph and is independent of the semantic relationship defined by the edges of the semantic graph. A graph activation is carried out for an input context relating to one or more concepts of the semantic graph, wherein the weightings are applied to a spreading activation signal through the semantic graph to produce a measure of the meta-relationship for a sub-set of concepts of the semantic graph.

Abstract: Method and system are provided for adaptive evaluation of meta-relationships in semantic graphs. The method includes providing a semantic graph based on a knowledge base in which concepts in the form of graph nodes are linked by semantic relationships in the form of graph edges. Metadata is encoded in the edges and nodes of the semantic graph, of weightings for measuring a meta-relationship, wherein the meta-relationship applies to the concepts of the semantic graph and is independent of the semantic relationship defined by the edges of the semantic graph. A graph activation is carried out for an input context relating to one or more concepts of the semantic graph, wherein the weightings are applied to a spreading activation signal through the semantic graph to produce a measure of the meta-relationship for a sub-set of concepts of the semantic graph.

Abstract: Disclosed is a computer implemented method, computer program product, and apparatus to decorate visible attributes of a rendered avatar. A server may collect a first user profile of a first avatar, the first user profile having at least one interest of a user. Next, the server may receive a location of the first avatar, wherein the location is associated with a view to at least a second avatar. The server can identify the second avatar among a group of avatars visible with respect to the first avatar. Further, the server may read a target profile of the second avatar then determine whether the second user profile satisfies a criterion based on the first user profile and the target profile. In addition, the server may render a modified rendered avatar to a client, responsive to the determination that the target profile satisfies the criterion.

Abstract: Disclosed is a computer implemented method, computer program product, and apparatus to decorate visible attributes of a rendered avatar. A server may collect a first user profile of a first avatar, the first user profile having at least one interest of a user. Next, the server may receive a location of the first avatar, wherein the location is associated with a view to at least a second avatar. The server can identify the second avatar among a group of avatars visible with respect to the first avatar. Further, the server may read a target profile of the second avatar then determine whether the second user profile satisfies a criterion based on the first user profile and the target profile. In addition, the server may render a modified rendered avatar to a client, responsive to the determination that the target profile satisfies the criterion.

Abstract: Illustrative embodiments provide a computer implemented method, a data processing system and a computer program product for locating contact information in a mobile phone network within a social network. In one embodiment, the computer implemented method permits reciprocal access between a first user's contact information and a second user's contact information by a first user device and a second user device, and permitting reciprocal access between the second user's contact information and a third user's contact information by the second user device and a third user device. The computer implemented method receives a request from the third user device to contact the first user device, wherein the first user contact information is unknown to the third user and issues a search on the mobile phone network, from the third user device, for the first user contact information.

Abstract: A method and apparatus is disclosed for representing data available in a peer-to-peer network of processing nodes. In one arrangement, respective Bloom-Filters may be formed at the nodes as a function of data available via the nodes. The Bloom-filters may be communicated between peer-to-peer coupled nodes of the peer-to-peer network that have formed connections using incentive-based criteria to control whether one node connects to another node. A search expression may be formed for locating a data object, and nodes selected as a function of the Bloom-filters and the incentive-based criteria. The search expression may be propagated to the selected nodes, and the result of the search expression output from nodes that satisfy the search expression.