Abstract: The present invention relates to new enantiomerically pure pyridylcycloalkylethylamines of formula 1a and 1b, the salts thereof as well as to methods of preparing them and their use as intermediate products.

Abstract: 3-Bromo-2,6-dimethoxybenzamides useful as neuroleptic agents are described.

Abstract: The invention relates to N-(2-methoxyethyl)-noroxymorphone and pharmacologically acceptable acid addition salts thereof. These compounds are analgesically effective and can be used for controlling pain.

Abstract: Compounds of the formula ##STR1## wherein Ar is ##STR2## R.sub.1 is hydrogen, fluorine, bromine, methyl or methoxy; X is .dbd.CO, .dbd.CH--CN, .dbd.CH--OH, --O--, --S--, --NH--, ##STR3## and R is hydrogen, 4-fluoro, 4-chloro, 4-trifluoromethyl, 3-trifluoromethyl, 3-trifluoromethyl-4-chloro, 4-methyl or 4-methoxy;and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as their salts are useful as neuroleptics.

Abstract: Compounds of the formula ##STR1## wherein R.sub.1 is chlorine, bromine or iodine,R.sub.2 is hydrogen or halogen, andR.sub.3 is hydrogen, lower alkyl or hydroxy-lower alkyl, or when R.sub.3 is hydrogen, an alkali metal salt thereof; the compounds and their salts are useful as anxiolytics, anticonvulsives and sedatives.

Abstract: Compounds of the formula ##STR1## wherein R.sub.1 is chlorine, bromine or alkyl of 1 to 3 carbon atoms;R.sub.2 is hydrogen or, when R.sub.1 is alkyl, chlorine or bromine;R.sub.1 and R.sub.2, together with each other, are straight alkylene of 3 to 4 carbon atoms;R.sub.3 is hydrogen, fluorine, chlorine, bromine, alkyl of 1 to 2 carbon atoms; hydroxyl or trifluoromethyl; andR.sub.4 is hydrogen, straight or branched alkyl of 1 to 4 carbon atoms or phenyl lower alkyl;and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as their salts are useful as antidepressants.

Abstract: A multiple-step process for the preparation of 6-aryl-4H-s-triazolo-[3,4-c]-thieno-[2,3-e]-1,4-diazepines of the formula ##STR1## wherein R.sub.1 is hydrogen, halogen or lower alkyl of 1 to 2 carbon atoms;R.sub.2 is hydrogen, chlorine, bromine, straight or branched alkyl of 1 to 3 carbon atoms, .omega.-hydroxyalkyl of 1 to 3 carbon atoms, cycloalkyl of 3 to 6 carbon atoms or a 5- or 6-membered heterocycle comprising an oxygen sulfur or nitrogen atom, where the nitrogen atom may optionally be substituted by lower alkyl; andR.sub.3 is hydrogen, fluorine, chlorine, or bromine;and optionally acid addition salts thereof, starting from compounds of the formula ##STR2## wherein R.sub.1 and R.sub.3 have the meanings defined above, andX is halogen, amino or acyloxy.

Abstract: Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen, lower alkyl, halo-lower alkyl, hydroxy-lower alkyl, di(lower alkyl)amino-lower alkyl, phenyl, tolyl, methoxy-phenyl, nitro-phenyl, halo-phenyl, pyridyl, pyrimidinyl or --CO--R.sub.4, where R.sub.4 is hydrogen, alkyl or 1 to 17 carbon atoms, alkoxy of 1 to 2 carbon atoms, phenyl, tolyl, methoxy-phenyl, halo-phenyl, nitro-phenyl or pyridyl;R.sub.2 is hydrogen, fluorine, chlorine, or bromine; andR.sub.3 is chlorine, bromine or lower alkyl,and non-toxic, pharmacologically acceptable acid addition salts of certain of these compounds. The compounds as well as the salts are useful as anxiolytics, tranquilizers, sedatives or neuroleptics.

Abstract: Compounds of the formula ##STR1## wherein R.sub.1 is alkyl of 1 to 6 carbon atoms, phenyl, substituted phenyl or heteroaryl;R.sub.2 is hydrogen or alkyl; andR.sub.3 is hydrogen, methyl, methoxy or halogen;And non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds are useful as neuroleptics.

Abstract: Diastereoisomers of the compound of the formula ##STR1## and non-toxic, pharmacologically acceptable acid addition salts thereof; the isomers as well as their salts are useful as analgesics and morphine-antagonists.

Abstract: Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen, acetyl, alkyl of 1 to 3 carbon atoms or phenyl, and non-toxic, pharmacologically acceptable acid addition salts thereof; the compounds as well as their salts are useful as CNS-depressants, sedatives and tranquilizers.

Abstract: Compounds of the formula ##STR1## wherein R.sub.1 is methyl, ethyl or propyl,R.sub.2 is hydrogen, methyl or ethyl,R.sub.3 is hydrogen or methyl, andR.sub.4 is hydrogen, alkyl of 1 to 4 carbon atoms or alkanoyl of 2 to 5 carbon atoms,And non-toxic, pharmacologically acceptable acid addition salts thereof; the compounds as well as the salts are useful as analgesics.

Abstract: Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen, halogen or methyl, andR.sub.2 is hydrogen, halogen, methyl or methoxy, and non-toxic, pharmacologically acceptable acid addition salts thereof; the compounds as well as their salts are useful as neuroleptics.

Abstract: Pharmaceutical compositions containing as an active ingredient compounds of the formula ##STR1## wherein R is hydrogen or methyl, or a non-toxic, pharmacologically acceptable acid addition salt thereof; and a method of using the same as morphine-antagonists and analgesics.

Abstract: Compounds of the formula ##STR1## wherein R is straight or branched alkyl of 1 to 4 carbon atoms, and non-toxic, pharmacologically acceptable acid addition salts thereof; the compounds as well as their salts are useful as sedatives and tranquilizers.

Abstract: Pharmaceutical compositions containing as an active ingredient a compound of the formula ##STR1## wherein R.sub.1 is methyl, ethyl or propyl, R.sub.2 is hydrogen, methyl or ethyl,R.sub.3 is hydrogen or methyl,R.sub.4 is ##STR2## R.sub.5 is hydrogen, methyl or acetyl, or a non-toxic, pharmacologically acceptable acid addition salt thereof; and a method of using the same as analgesics.

Abstract: Compounds of the formula ##STR1## wherein R is hydrogen or methyl, and non-toxic, pharmacologically acceptable acid addition salts thereof; the compounds as well as their salts are useful as morphine-antagonists and analgesics.

Abstract: Pharmaceutical compositions containing as an active ingredient a compound of the formula ##STR1## wherein R is hydrogen, methyl or acetyl,R.sub.1 is methyl, phenyl or hydrogen,Z is --CH=CH-- or --CH.sub.2 --CH.sub.2 --, andR.sub.3 is hydrogen or methyl,And non-toxic, pharmacologically acceptable acid addition salts thereof; and a method using the same as analgesics and antitussives.

Abstract: Pharmaceutical compositions containing as an active ingredient a compound of the formula ##STR1## wherein R is hydrogen, methyl or acetyl,R.sub.1 and R.sub.2, which may be identical to or different from each other, are each alkyl of 1 to 3 carbon atoms,R.sub.3 is hydrogen or methyl, andY is oxygen or sulfur,Or a non-toxic, pharmacologically acceptable acid addition salt thereof; and a method of using the same as analgesics, antitussives and opiate-antagonists.

Abstract: Pharmaceutical compositions containing as an active ingredient a compound of the formula ##SPC1##WhereinR is straight or branched alkyl of 1 to 3 carbon atoms, alkoxy of 1 to 2 carbon atoms or phenyl, andn is an integer from 2 to 4, inclusive,Or a non-toxic, pharmacologically acceptable acid addition salt thereof; and a method of using the same as non-narcotic analgesics.