Patents by Inventor Adolph E. Sloboda

Adolph E. Sloboda has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 2-Phenyl-4-quinoline carboxylic acids
    Patent number: 4847381
    Abstract: Substituted 4-quinoline-carboxylic acids useful in the treatment of arthritis and inhibition of progressive joint deterioration are disclosed together with methods of use and synthesis thereof.
    Type: Grant
    Filed: August 31, 1987
    Date of Patent: July 11, 1989
    Assignee: American Cyanamid Company
    Inventors: Leslie H. Sutherland, Adolph E. Sloboda, Ralph G. Child, John F. Poletto, Dennis W. Powell
  • Treatment of arthritis with 3,5-dichloromethotrexate
    Patent number: 4746662
    Abstract: Joint destruction associated with arthritic disease in warm blooded animals is treated with unexpected safety using 3,5-dichloromethotrexate. The therapeutic index therefor is unexpectedly enhanced through combination therapy using a post administration of leucovorin.
    Type: Grant
    Filed: February 20, 1987
    Date of Patent: May 24, 1988
    Assignee: American Cyanamid Company
    Inventors: Suresh S. Kerwar, Adolph E. Sloboda
  • Method of treating multiple sclerosis
    Patent number: 4617319
    Abstract: A method of treating neuroimmunologic diseases such as multiple sclerosis and acute disseminated encephalomyelitis using 1,4-dihydroxy-5,8-bis[[(2-hydroxyethylamino)ethyl]amino]anthraquinone, or a pharmacologically acceptable acid addition salt thereof.
    Type: Grant
    Filed: June 13, 1985
    Date of Patent: October 14, 1986
    Assignee: American Cyanamid Company
    Inventors: Suresh S. Kerwar, Adolph E. Sloboda, Susan C. Ridge
  • Method of treating arthritic disease
    Patent number: 4486430
    Abstract: This disclosure describes compositions of matter useful as anti-inflammatory agents and as inhibitors of the progressive joint deterioration characteristic of arthritic disease and the methods of meliorating inflammation and of inhibiting joint deterioration in mammals therewith, the active ingredients of said compositions of matter being certain 2,4,6-tris(substituted-amino)-s-triazines.
    Type: Grant
    Filed: March 27, 1980
    Date of Patent: December 4, 1984
    Assignee: American Cyanamid Company
    Inventors: Andrew S. Tomcufcik, Adolph E. Sloboda
  • Combinations of agents which give enhanced anti-inflammatory activity
    Patent number: 4390545
    Abstract: This disclosure describes compatible additive anti-inflammatory compositions comprising certain novel anti-arthritic agents and the known non-steroidal anti-inflammatory agents.
    Type: Grant
    Filed: July 6, 1982
    Date of Patent: June 28, 1983
    Assignee: American Cyanamid Company
    Inventor: Adolph E. Sloboda
  • Combinations of agents which give enhanced anti-inflammatory activity
    Patent number: 4350689
    Abstract: This disclosure describes compatible additive anti-inflammatory compositions comprising certain novel anti-arthritic agents and the known non-steroidal anti-inflammatory agents.
    Type: Grant
    Filed: November 19, 1981
    Date of Patent: September 21, 1982
    Assignee: American Cyanamid Company
    Inventor: Adolph E. Sloboda
  • Combinations of agents which give enhanced anti-inflammatory activity
    Patent number: 4325949
    Abstract: This disclosure describes compatible additive anti-inflammatory compositions comprising certain novel anti-arthritic agents and the known non-steroidal anti-inflammatory agents.
    Type: Grant
    Filed: December 23, 1980
    Date of Patent: April 20, 1982
    Assignee: American Cyanamid Company
    Inventor: Adolph E. Sloboda
  • Method of treating arthritic disease
    Patent number: 4269832
    Abstract: This disclosure describes compositions of matter useful as anti-inflammatory agents and as inhibitors of the progressive joint deterioration characteristic of arthritic disease and the methods of meliorating inflammation and of inhibiting joint deterioration in mammals therewith, the active ingredients of said compositions of matter being certain 2-(substituted-amino)-4,6-bis(alkylamino)-s-triazines.
    Type: Grant
    Filed: November 19, 1979
    Date of Patent: May 26, 1981
    Assignee: American Cyanamid Company
    Inventors: Andrew S. Tomcufcik, Adolph E. Sloboda
  • 2,4,6-Tris-(substituted-amino)-s-triazines
    Patent number: 4261892
    Abstract: This disclosure describes new compounds and compositions of matter useful as anti-inflammatory agents and as inhibitors of the progressive joint deterioration characteristic of arthritic disease and the methods of meliorating inflammation and of inhibiting joint deterioration in mammals therewith, the active ingredients of said compositions of matter being certain 2,4,6-tris(substituted-amino)-s-triazines.
    Type: Grant
    Filed: March 5, 1979
    Date of Patent: April 14, 1981
    Assignee: American Cyanamid Company
    Inventors: Andrew S. Tomcufcik, Adolph E. Sloboda
  • Alkali metal and alkaline earth metal salts of benzoylacetonitriles
    Patent number: 4197312
    Abstract: This disclosure describes new compounds and compositions of matter useful as anti-inflammatory agents and as inhibitors of the progressive joint deterioration characteristic of arthritic disease and the methods of meliorating inflammation and of inhibiting joint deterioration in mammals therewith, the novel active ingredients of said compositions of matter being the pharmacologically acceptable cationic salts of benzoylacetonitrile, o-fluorobenzoylacetonitrile, m-fluorobenzoylacetonitrile, p-fluorobenzoylacetonitrile, or mixtures thereof.
    Type: Grant
    Filed: May 9, 1978
    Date of Patent: April 8, 1980
    Assignee: American Cyanamid Company
    Inventors: Adolph E. Sloboda, John W. Hanifin, Jr.
  • Method of treating arthritic disease
    Patent number: 4189497
    Abstract: This disclosure describes compositions of matter useful as anti-inflammatory agents and as inhibitors of the progressive joint deterioration characteristic of arthritic disease, and the methods of meliorating inflammation and of inhibiting joint deterioration in mammals therewith, the active ingredient of said compositions of matter being .beta.-oxo-2-thiophenepropionitrile or the pharmaceutically acceptable cationic salts thereof.
    Type: Grant
    Filed: August 22, 1978
    Date of Patent: February 19, 1980
    Assignee: American Cyanamid Company
    Inventors: John W. Hanifin, Adolph E. Sloboda
  • Compositions and method of use to treat arthritic disease with m-fluorobenzimidoylacetonitrile
    Patent number: 4167580
    Abstract: This disclosure describes compositions of matter useful as anti-inflammatory agents and as inhibitors of the progressive joint deterioration characteristic of arthritic disease, and the methods of meliorating inflammation and of inhibiting joint deterioration in mammals therewith, the active ingredients of said compositions of matter being benzimidoylacetonitrile, meta-fluorobenzimidoylacetonitrile, para-fluorobenzimidoylacetonitrile, or mixtures thereof.
    Type: Grant
    Filed: September 13, 1978
    Date of Patent: September 11, 1979
    Assignee: American Cyanamid Company
    Inventor: Adolph E. Sloboda
  • Compositions of matter and method of use to treat arthritic disease
    Patent number: 4134990
    Abstract: This disclosure describes compositions of matter useful as anti-inflammatory agents and as inhibitors of the progressive joint deterioration characteristic of arthritic disease, and the methods of meliorating inflammation and of inhibiting joint deterioration in mammals therewith, the active ingredients of said compositions of matter being benzimidoylacetonitrile, meta-fluorobenzimidoylacetonitrile, para-fluorobenzimidoylacetonitrile, or mixtures thereof.
    Type: Grant
    Filed: November 22, 1977
    Date of Patent: January 16, 1979
    Assignee: American Cyanamid Company
    Inventor: Adolph E. Sloboda