Patents by Inventor Adriaan M. van Leusen

Adriaan M. van Leusen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Novel 17-substituted steroids
    Patent number: 4647410
    Abstract: Novel 17-(formamidosulfonylmethylene)-steroids of the formula ##STR1## useful as intermediates for the novel 17-(isocyanosulfonylmethylene)-steroids of the formula ##STR2## which are useful intermediates for 21-hydroxy-20-keto-.DELTA..sup.16 -steroids and 20-keto-.DELTA..sup.16 -steroids.
    Type: Grant
    Filed: April 27, 1984
    Date of Patent: March 3, 1987
    Assignee: Gist-Brocades N.V.
    Inventors: Albert M. van Leusen, Adriaan M. van Leusen
  • Preparation of 20-keto-.DELTA..sup.16 -steroids
    Patent number: 4551278
    Abstract: A novel process for the preparation of 20-keto-.DELTA..sup.16 -steroids comprising reacting a 17-(isocyanosulfonylmethylene)-steroid with an alkylating agent QR.sub.4 wherein R.sub.4 is an organic group and Q is a group or atom readily displaced with a nucleophile to form a 20-isocyano-20-sulfonyl-.DELTA..sup.16 -steroid followed by hydrolysis which are intermediates for the preparation of corticosteroids and the novel intermediates formed therein.
    Type: Grant
    Filed: April 27, 1984
    Date of Patent: November 5, 1985
    Assignee: Gist-Brocades N.V.
    Inventors: Albert M. van Leusen, Adriaan M. van Leusen
  • Process for the preparation of 21-hydroxy-20-keto-.DELTA..sup.16 -steroids and new intermediate compounds formed in this process
    Patent number: 4548749
    Abstract: A novel process for the preparation of 21-hydroxy-20-keto-.DELTA..sup.16 -steroids comprising reacting a 17-(isocyanosulfonylmethylene)-steroid with an aldehyde and an alcohol to form a 17-(2-alkoxy-3-oxazolin-4-yl)-.DELTA..sup.16 -steroid and subjecting the latter to hydrolysis to obtain the corresponding 21-hydroxy-20-keto-.DELTA..sup.16 -steroid which are useful to prepare corticoid steroids and novel intermediates.
    Type: Grant
    Filed: April 27, 1984
    Date of Patent: October 22, 1985
    Assignee: Gist-Brocades N.V.
    Inventors: Albert M. van Leusen, Adriaan M. van Leusen