Patents by Inventor Adriaan Pieter Ijzerman

Adriaan Pieter Ijzerman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • [1,2,3]triazolo[4,5-D]pyrimidine derivatives with affinity for the type-2 cannabinoid receptor
    Patent number: 10457685
    Abstract: The invention relates to a compound of formula (I) wherein R1 to R4 and n are defined as in the description and in the claims. The compound of formula (I) can be used as a medicament.
    Type: Grant
    Filed: December 20, 2018
    Date of Patent: October 29, 2019
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Luca Gobbi, Uwe Grether, Wolfgang Guba, Julian Kretz, Rainer E. Martin, Matthias Valentin Westphal, Adriaan Pieter Ijzerman
  • [1,2,3]triazolo[4,5-D]pyrimidine derivatives
    Patent number: 10450321
    Abstract: The invention relates to a compound of formula (I) wherein R1 to R4 are defined as in the description and in the claims. The compound of formula (I) can be used as a medicament.
    Type: Grant
    Filed: December 20, 2018
    Date of Patent: October 22, 2019
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Luca Gobbi, Uwe Grether, Wolfgang Guba, Julian Kretz, Rainer E. Martin, Matthias Valentin Westphal, Adriaan Pieter Ijzerman
  • [1,2,3]TRIAZOLO[4,5-D]PYRIMIDINE DERIVATIVES WITH AFFINITY FOR THE TYPE-2 CANNABINOID RECEPTOR
    Publication number: 20190127384
    Abstract: The invention relates to a compound of formula (I) wherein R1 to R4 and n are defined as in the description and in the claims. The compound of formula (I) can be used as a medicament.
    Type: Application
    Filed: December 20, 2018
    Publication date: May 2, 2019
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Luca GOBBI, Uwe GRETHER, Wolfgang GUBA, Julian KRETZ, Rainer E. MARTIN, Matthias Valentin WESTPHAL, Adriaan Pieter IJZERMAN
  • NOVEL [1,2,3]TRIAZOLO[4,5-D]PYRIMIDINE DERIVATIVES
    Publication number: 20190127385
    Abstract: The invention relates to a compound of formula (I) wherein R1 to R4 are defined as in the description and in the claims. The compound of formula (I) can be used as a medicament.
    Type: Application
    Filed: December 20, 2018
    Publication date: May 2, 2019
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Luca Gobbi, Uwe Grether, Wolfgang Guba, Julian Kretz, Rainer E. Martin, Matthias Valentin Westphal, Adriaan Pieter Ijzerman
  • SPHINGOSINE-1-PHOSPHATE (S1P) RECEPTOR COMPOUNDS
    Publication number: 20100317709
    Abstract: The invention relates to compounds, in particular 2-amino-3,4,5,-trisubstituted thiophenes, pharmaceutical compositions containing them and the uses of said compounds and compositions for diseases related to sphingosine-1-phosphate (S1P) receptors, predominantly S1P3 receptors. The diseases include cardiovascular diseases, atherosclerosis, cancer, pulmonary oedema, autoimmune disorders and Adult Respiratory Distress Syndrome.
    Type: Application
    Filed: November 13, 2008
    Publication date: December 16, 2010
    Inventors: Johannes Brussee, Adriaan Pieter Ijzerman, Astrid Eline Alewijnse, Stephan Leonard Maria Peters, Margot Wilhelmia Beukers
  • 2,6,8, Trisubstituted 1-deazapurines and their different uses
    Publication number: 20080139608
    Abstract: The invention provides a compound having the structure of general formula (I): or a salt thereof, wherein, R represents hydrogen (except when R?=H), halogen, (substituted) alkyl except —CH3, (substituted) alkenyl, (substituted) alkynyl, or (substituted) —(CH2)n-aryl; R? represents hydrogen (except when R=H), halogen, (substituted) alkyl except —CH3, (substituted) alkenyl, (substituted) alkynyl, or (substituted) —CH2)n-aryl; R? represents hydrogen, —(CH2)n-hydroxyl, halogen, acyl, thio-acyl, seleno-acyl, (substituted) alkyl, (substituted) alkenyl, (substituted) alkynyl, or (substituted) —(CH2)n-aryl; and n is a number in the range from 0 to 10. The invention further provides pharmaceutical compositions comprising said compound, and the use of said compound to treat and/or prevent a variety of diseases.
    Type: Application
    Filed: December 6, 2006
    Publication date: June 12, 2008
    Applicant: Universiteit Leiden
    Inventors: Lisa Chung Wai Chang, Johannes Brussee, Adriaan Pieter IJzerman
  • Analogs of nitrobenzylthioinosine
    Patent number: 7358235
    Abstract: Analogs or derivatives of nitrobenzylthioinosine compounds. The use of these new analogs of nitrobenzylthioinosine and methods for the treatment of pain and various other indications using these analogs of nitrobenzylthioinosine as well as pharmaceutical compositions including analogs of nitrobenzylthioinosine.
    Type: Grant
    Filed: October 6, 2004
    Date of Patent: April 15, 2008
    Assignees: Gruenenthal GmbH, Leiden University
    Inventors: Claudia Puetz, Corinna Sundermann, Bernd Sundermann, Adriaan Pieter Ijzerman, Reynier Tromp, Jacobien Von Frijtag Drabbe Kuenzel