Patents by Inventor Adriaan Thomas Vermaire

Adriaan Thomas Vermaire has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for enhancing phagocytosis of phosphatidylserine-exposing cells
    Patent number: 8658768
    Abstract: An Annexin A5 variant, comprising one or more RGD (Arg-Gly-Asp) sequences, is suitable for use in the treatment of a disease in mammals, including humans, wherein augmentation of phagocytosis is a desired effect of treatment. The Annexin A5 variant can e.g. be used in the treatment of chronic inflammatory diseases such as atherosclerotic plaque or in the treatment of COPD. At least one RGD sequence may substitute sequences of three amino acids within the range 1-19 or other regions of the amino acid sequences of Annexin A5; alternatively one or more RGD sequences may be part of an extension at the N-terminal side.
    Type: Grant
    Filed: June 3, 2010
    Date of Patent: February 25, 2014
    Assignee: Mosamedix B.V.
    Inventors: Christiaan Peter Maria Reutelingsperger, Peter Jozef Jacobus Moonen, Adriaan Thomas Vermaire
  • METHOD FOR ENHANCING PHAGOCYTOSIS OF PHOSPHATIDYLSERINE-EXPOSING CELLS
    Publication number: 20120094895
    Abstract: An Annexin A5 variant, comprising one or more RGD (Arg-Gly-Asp) sequences, is suitable for use in the treatment of a disease in mammals, including humans, wherein augmentation of phagocytosis is a desired effect of treatment. The Annexin A5 variant can e.g. be used in the treatment of chronic inflammatory diseases such as atherosclerotic plaque or in the treatment of COPD. At least one RGD sequence may substitute sequences of three amino acids within the range 1-19 or other regions of the amino acid sequences of Annexin A5; alternatively one or more RGD sequences may be part of an extension at the N-terminal side.
    Type: Application
    Filed: June 3, 2010
    Publication date: April 19, 2012
    Inventors: Christiaan Peter Maria Reutelingsperger, Adriaan Thomas Vermaire