Abstract: The disclosure features macrocyclic compounds, alone and in combination with other therapeutic agents, as well as pharmaceutical compositions and protein complexes thereof, capable of modulating biological processes including RAS and RAS-RAF inhibition, and their uses in the treatment of cancers.

Abstract: The present disclosure is directed to inhibitors of SHP2 and their use in the treatment of disease. Also disclosed are pharmaceutical compositions comprising the same.

Abstract: The present disclosure is directed to inhibitors of SHP2 and their use in the treatment of disease. Also disclosed are pharmaceutical compositions comprising the same.

Abstract: In a first aspect of the invention, a pneumatic tire is provided, the pneumatic tire comprising two spaced apart beads, a tread portion, a pair of sidewalls extending radially inward from axially outer edges of the tread portion to join the respective beads, the axially outer edges of the tread portion defining a tread width, a carcass, an innerliner covering the carcass and enclosing a tire cavity when mounted on a rim, and multiple layers of open cell, noise damping foam strip material attached on top of each other to the innerliner within the tire cavity in an area radially below the tread portion, wherein each layer has an axial width from 20% to 80% of the tread width and a radial thickness from 5% to 20% of the tread width and said multiple layers fill together from 8% to 40% of the volume of the tire cavity.

Abstract: A field replaceable desiccant cartridge and device, method and system there for is provided. The cartridge comprises: a housing comprising an insertion end configured to removably mate with an aperture of a device, the insertion end configured to generally prevent moisture from entering the device when mated; a desiccant located in the housing; a circuit located within the housing, the circuit in contact with the desiccant, the circuit configured to change resistance as the desiccant changes in moisture content; one or more electrodes located at an exterior of the insertion end, the one or more electrodes in contact with the circuit; and, one or more holes through the insertion end, configured to expose the desiccant to an exterior of the housing so that the desiccant can absorb moisture there from. Devices configured with the cartridge can report moisture levels to a server, which can track problems associated with moisture in the devices.

Abstract: A system, method, device, and apparatus provide a dielectric waveguide splitter/bi-directional link. A dielectric substrate fabricated into a first Y-junction waveguide with a first port splitting into a first branch leading to a second port and a second branch leading to a third port. An angle between the first branch and the second branch is below ninety degrees (90°). The dielectric waveguide splitter enables millimeter-wave (mmWave) transmission between the first port and the second port while reducing feedback of the mmWave between the second and third port. Two Y-junction waveguides may be fabricated back-to-back to provide simultaneous bidirectional mmWave transmission at a single frequency.

Abstract: A field replaceable desiccant cartridge and device, method and system there for is provided. The cartridge comprises: a housing comprising an insertion end configured to removably mate with an aperture of a device, the insertion end configured to generally prevent moisture from entering the device when mated; a desiccant located in the housing; a circuit located within the housing, the circuit in contact with the desiccant, the circuit configured to change resistance as the desiccant changes in moisture content; one or more electrodes located at an exterior of the insertion end, the one or more electrodes in contact with the circuit; and, one or more holes through the insertion end, configured to expose the desiccant to an exterior of the housing so that the desiccant can absorb moisture there from. Devices configured with the cartridge can report moisture levels to a server, which can track problems associated with moisture in the devices.

Abstract: A system, method, device, and apparatus provide a dielectric waveguide splitter/bi-directional link. A dielectric substrate fabricated into a first Y-junction waveguide with a first port splitting into a first branch leading to a second port and a second branch leading to a third port. An angle between the first branch and the second branch is below ninety degrees (90°). The dielectric waveguide splitter enables millimeter-wave (mmWave) transmission between the first port and the second port while reducing feedback of the mmWave between the second and third port. Two Y-junction waveguides may be fabricated back-to-back to provide simultaneous bidirectional mmWave transmission at a single frequency.

Abstract: A method is provided for presenting battery degradation of a rechargeable battery to a user of an electronic device. The method comprising the following steps. An initial capacity and a remaining capacity of the rechargeable battery are obtained. The battery degradation is determined as a proportion of a difference between the initial capacity and the remaining capacity to the initial capacity. The battery degradation is visually displayed on a display of the electronic device as a battery gauge. A system to implement the method is also provided.

Abstract: Method and apparatus for creating collections with automatic suggestions is disclosed. In one embodiment, a method comprises receiving a user specification containing at least one unquantified constraint defining particular items contained in a library, where the library comprises a plurality of items and metadata associated with each item in the plurality of items; parsing and translating the at least one unquantified constraint into at least one quantified constraint to define at least one item of the plurality of items in the library; creating a suggested collection comprising at least one suggested item selected from the library having metadata conforming to at least one quantified constraint; and refining the suggested collection to form a final collection.

Abstract: The present application is concerned with processes and apparatuses for the separation of nitrogen from liquefied natural gas feeds. The processes comprise the steps of: (i) cooling the feed and passing the feed to a fractionation column; (ii) withdrawing from the fractionation column an overhead vapour stream having an enriched nitrogen content, and a liquid stream having a reduced nitrogen content; (iii) dividing the overhead vapour stream from step (ii) into at least first and second overhead streams; (iv) compressing, cooling and at least partially condensing at least the first overhead stream from step (iii); and (v) expanding the stream from step (iv) and passing the expanded stream to the fractionation column as reflux, and wherein cooling in step (iv) is provided, at least in part, by heat exchange with one or more streams from the fractionation column.

Abstract: A method and system for controlling the read range of a portable RFID reader is provided. The system includes a trigger system including a mechanical actuator manually positionable by a user and a sensor for sensing the position of the actuator. The read range of the RFID reader is changed based on the sensing result.

Abstract: The invention provides a process and apparatus for the separation of a gaseous feed comprising a mixture of hydrocarbons and nitrogen gas, the process comprising the steps of: (i) cooling and at least partially condensing the gaseous feed; (ii) feeding the cooled and at least partially condensed feed from step (i) to a fractionation column comprising reboil to produce an overhead hydrocarbon vapour stream enriched in nitrogen and a condensed hydrocarbon product stream low in nitrogen, wherein prior to the fractionation, the feed stream is divided into at least two streams including: a) a first stream which is expanded and fed to the fractionation column; b) a second stream which is expanded, heated and fed to a lower stage of the fractionation column than the first stream, (iii) removing a hydrocarbon product stream low in nitrogen from the fractionation column; and (iv) removing a hydrocarbon vapour stream enriched in nitrogen from the fractionation column.

Abstract: A method and system for power control for Radio Frequency Identification (RFID) tag reading is provided. The system includes a power amplifier for providing an RF transmit signal for the RFID tag reading. The RF transmit signal is provided to an antenna for radiating the transmit signal. The power of the radiated transmit signal defining a read range for the RFID tag reading. The system includes an attenuator provided between the power amplifier and the antenna for controlling the power of the radiated transmit signal to adjust the read range. A handheld RFID reader may include the system. The method includes calibrating the output power of a reader having a power amplifier and an attenuator provided between the power amplifier and an antenna. The step of calibrating includes at least one of controlling power of the power amplifier in its linear region, and controlling attenuation level of the attenuator.

Abstract: A computing device is configured to communicate with a peripheral via a connector having a predefined physical configuration and a predefined number of pins. The computing device comprising memory for storing instructions and a processor for executing the instructions. The instructions cause the processor to implement the following steps. Communication with the peripheral is initialized using a predefined initialization protocol via at least one predefined pin. Information relating to a pinout configuration defining a logical configuration of the pins is received from the peripheral. The pinout configuration is assigned to the pins. Communicating with the peripheral in commenced using the pinout configuration. A peripheral configured to communicate with the computing device and the methods for communicating there between are also described.

Abstract: A method is provided for presenting battery degradation of a rechargeable battery to a user of an electronic device. The method comprising the following steps. An initial capacity and a remaining capacity of the rechargeable battery are obtained. The battery degradation is determined as a proportion of a difference between the initial capacity and the remaining capacity to the initial capacity. The battery degradation is visually displayed on a display of the electronic device as a battery gauge. A system to implement the method is also provided.

Abstract: A method and system for controlling the read range of a portable RFID reader is provided. The system includes a trigger system including a mechanical actuator manually positionable by a user and a sensor for sensing the position of the actuator. The read range of the RFID reader is changed based on the sensing result.

Abstract: A method and system for power control for Radio Frequency Identification (RFID) tag reading is provided. The system includes a power amplifier for providing an RF transmit signal for the RFID tag reading. The RF transmit signal is provided to an antenna for radiating the transmit signal. The power of the radiated transmit signal defining a read range for the RFID tag reading. The system includes an attenuator provided between the power amplifier and the antenna for controlling the power of the radiated transmit signal to adjust the read range. A handheld RFID reader may include the system. The method includes calibrating the output power of a reader having a power amplifier and an attenuator provided between the power amplifier and an antenna. The step of calibrating includes at least one of controlling power of the power amplifier in its linear region, and controlling attenuation level of the attenuator.

Abstract: A method, system and support mechanism for object identification is provided. A removable handheld terminal is operable as a stand-alone device. A fixture is connectable to the handheld terminal for a portal use. The terminal includes one or more sensors being automatically or manually activated. The fixture includes a docking member for removably connecting the handheld terminal to the fixture.