Patents by Inventor Adrian Bird

Adrian Bird has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240165270
    Abstract: MECP2 EXPRESSION CASSETTES. The present invention provides nucleic acid molecules comprising a MeCP2 expression cassette, the expression cassette comprising, in operable linkage from 5? to 3?: a 5? transcriptional control region comprising a promoter capable of driving transcription in neural cells; an open reading frame encoding a MeCP2 protein; translation control signals; a 3? untranslated region (3?UTR) comprising one or more of: (i) a binding site for mir-22; (ii) a binding site for mir-19; (iii) a binding site for miR-132; (iv) a binding site for miR124; and (v) an AU-rich element; and transcriptional termination signals; wherein the MeCP2 expression cassette is not more than about 5 kb in length. The invention further provides viral vectors, especially vectors derived from adeno-associated virus (AAV), for use in therapeutic delivery of such expression cassettes.
    Type: Application
    Filed: November 7, 2023
    Publication date: May 23, 2024
    Inventors: Adrian BIRD, Rebekah TILLOTSON, Stuart Robert COBB, Ralph David HECTOR
  • Patent number: 11969479
    Abstract: The present invention provides nucleic acid molecules comprising a MeCP2 expression cassette, the expression cassette comprising, in operable linkage from 5? to 3?: a 5? transcriptional control region comprising a promoter capable of driving transcription in neural cells; an open reading frame encoding a MeCP2 protein; translation control signals; a 3? untranslated region (3?UTR) comprising one or more of: (i) a binding site for mir-22; (ii) a binding site for mir-19; (iii) a binding site for miR-132; (iv) a binding site for miR124; and (v) an AU-rich element; and transcriptional termination signals; wherein the MeCP2 expression cassette is not more than about 5 kb in length. The invention further provides viral vectors, especially vectors derived from adeno-associated virus (AAV), for use in therapeutic delivery of such expression cassettes.
    Type: Grant
    Filed: March 23, 2018
    Date of Patent: April 30, 2024
    Assignees: THE UNIVERSITY COURT OF THE UNIVERSITY OF EDINBURGH, THE UNIVERSITY COURT OF THE UNIVERSITY OF GLASGOW
    Inventors: Adrian Bird, Rebekah Tillotson, Stuart Robert Cobb, Ralph David Hector
  • Publication number: 20210101938
    Abstract: MeCP2 based therapy. The present invention relates to synthetic polypeptides that are useful in the treatment of disorders associated with reduced MeCP2 activity, including Rett syndrome. The present invention provides synthetic polypeptides comprising: i) an MBD amino acid sequence showing at least 70% similarity with the amino acid sequence showing at least 70% similarity with the amino acid sequence as depicted in SEQ ID NO: 2, wherein the polypeptide has a deletion of at least 50 amino acids, when compared to the full length MeCP2 e1 and e2 sequences. The invention further provides nucleic acid constructs, expression vectors, virions, pharmaceutical compositions, and cells providing polynucleotides of the invention. The invention further provides methods of treating or preventing disease in an animal comprising administering to said animal a synthetic polypeptide according to the invention.
    Type: Application
    Filed: March 23, 2018
    Publication date: April 8, 2021
    Inventors: Adrian BIRD, Rebekah TILLOTSON, Stuart Robert COBB, Ralph David HECTOR
  • Publication number: 20200016279
    Abstract: The present invention provides nucleic acid molecules comprising a MeCP2 expression cassette, the expression cassette comprising, in operable linkage from 5? to 3?: a 5? transcriptional control region comprising a promoter capable of driving transcription in neural cells; an open reading frame encoding a MeCP2 protein; translation control signals; a 3? untranslated region (3?UTR) comprising one or more of: (i) a binding site for mir-22; (ii) a binding site for mir-19; (iii) a binding site for miR-132; (iv) a binding site for miR124; and (v) an AU-rich element; and transcriptional termination signals; wherein the MeCP2 expression cassette is not more than about 5 kb in length. The invention further provides viral vectors, especially vectors derived from adeno-associated virus (AAV), for use in therapeutic delivery of such expression cassettes.
    Type: Application
    Filed: March 23, 2018
    Publication date: January 16, 2020
    Inventors: Adrian BIRD, Rebekah TILLOTSON, Stuart Robert COBB, Ralph David HECTOR
  • Patent number: 8594924
    Abstract: An asset operational health monitoring system, in which a plurality of sensors are arranged to determine values of asset operation parameters pertaining to an instance of asset operation. One or more processing unit receives data corresponding to said asset operation values and determine a plurality of asset locations at a corresponding plurality of points in time. The one or more processing unit is arranged to receive data indicative of the location of a region of adverse environmental conditions which may impact on the operation of the asset and to compare the determined locations of the asset with the location of said region so as to determine whether one or more of said asset locations fall within said region. An indicator of operational risk associated with the presence of said asset in said region is output which can drive asset operation or maintenance decision making. The system may be used for ash cloud impact monitoring for aircraft, a fleet of aircraft or aircraft engines.
    Type: Grant
    Filed: July 12, 2012
    Date of Patent: November 26, 2013
    Assignee: Rolls-Royce, PLC
    Inventors: Stephen P. King, Adrian Bird, Paul A. Flint, Daniel K. Goodall
  • Publication number: 20130054056
    Abstract: An asset operational health monitoring system, in which a plurality of sensors are arranged to determine values of asset operation parameters pertaining to an instance of asset operation. One or more processing unit receives data corresponding to said asset operation values and determine a plurality of asset locations at a corresponding plurality of points in time. The one or more processing unit is arranged to receive data indicative of the location of a region of adverse environmental conditions which may impact on the operation of the asset and to compare the determined locations of the asset with the location of said region so as to determine whether one or more of said asset locations fall within said region. An indicator of operational risk associated with the presence of said asset in said region is output which can drive asset operation or maintenance decision making. The system may be used for ash cloud impact monitoring for aircraft, a fleet of aircraft or aircraft engines.
    Type: Application
    Filed: July 12, 2012
    Publication date: February 28, 2013
    Applicant: ROLLS-ROYCE PLC
    Inventors: Stephen P. KING, Adrian BIRD, Paul A. FLINT, Daniel K. GOODALL
  • Publication number: 20080076671
    Abstract: The present invention relates to a method of isolating fragments of nucleic acid according to the density of CpG dinucleotides and subsequent procedures for producing a library and/or an array or microarray of these fragments, as well as uses thereof.
    Type: Application
    Filed: October 31, 2005
    Publication date: March 27, 2008
    Applicant: University Court of the University of Edinburgh
    Inventors: Adrian Bird, Robert Illingworth, Helle Jorgensen
  • Patent number: D796956
    Type: Grant
    Filed: May 27, 2014
    Date of Patent: September 12, 2017
    Assignee: Life Technologies Corporation
    Inventors: Paul Clark, Sandro Klein, Xin Mathers, Jeffrey Kelly, David Judd, Scott Glassman, Michael Scribner, Adrian Bird, Imran Mahmood
  • Patent number: D796961
    Type: Grant
    Filed: January 11, 2016
    Date of Patent: September 12, 2017
    Assignee: Life Technologies Corporation
    Inventors: Sandro Klein, Xin Mathers, Pawel Zygier, Adrian Bird
  • Patent number: D840826
    Type: Grant
    Filed: July 28, 2017
    Date of Patent: February 19, 2019
    Assignee: LIFE TECHNOLOGIES CORPORATION
    Inventors: Paul Clark, Sandro Klein, Xin Mathers, Jeffrey Kelly, David Judd, Scott Glassman, Michael Scribner, Adrian Bird, Imran Mahmood
  • Patent number: D901306
    Type: Grant
    Filed: February 15, 2019
    Date of Patent: November 10, 2020
    Assignee: LIFE TECHNOLOGIES CORPORATION
    Inventors: Paul Clark, Sandro Klein, Xin Mathers, Jeffrey Kelly, David Judd, Scott Glassman, Michael Scribner, Adrian Bird, Imran Mahmood
  • Patent number: D1039382
    Type: Grant
    Filed: November 5, 2020
    Date of Patent: August 20, 2024
    Assignee: Life Technologies Corporation
    Inventors: Paul Clark, Sandro Klein, Xin Mathers, Jeffrey Kelly, David Judd, Scott Glassman, Michael Scribner, Adrian Bird, Imran Mahmood