Patents by Inventor Adrian Bird
Adrian Bird has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240165270Abstract: MECP2 EXPRESSION CASSETTES. The present invention provides nucleic acid molecules comprising a MeCP2 expression cassette, the expression cassette comprising, in operable linkage from 5? to 3?: a 5? transcriptional control region comprising a promoter capable of driving transcription in neural cells; an open reading frame encoding a MeCP2 protein; translation control signals; a 3? untranslated region (3?UTR) comprising one or more of: (i) a binding site for mir-22; (ii) a binding site for mir-19; (iii) a binding site for miR-132; (iv) a binding site for miR124; and (v) an AU-rich element; and transcriptional termination signals; wherein the MeCP2 expression cassette is not more than about 5 kb in length. The invention further provides viral vectors, especially vectors derived from adeno-associated virus (AAV), for use in therapeutic delivery of such expression cassettes.Type: ApplicationFiled: November 7, 2023Publication date: May 23, 2024Inventors: Adrian BIRD, Rebekah TILLOTSON, Stuart Robert COBB, Ralph David HECTOR
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Patent number: 11969479Abstract: The present invention provides nucleic acid molecules comprising a MeCP2 expression cassette, the expression cassette comprising, in operable linkage from 5? to 3?: a 5? transcriptional control region comprising a promoter capable of driving transcription in neural cells; an open reading frame encoding a MeCP2 protein; translation control signals; a 3? untranslated region (3?UTR) comprising one or more of: (i) a binding site for mir-22; (ii) a binding site for mir-19; (iii) a binding site for miR-132; (iv) a binding site for miR124; and (v) an AU-rich element; and transcriptional termination signals; wherein the MeCP2 expression cassette is not more than about 5 kb in length. The invention further provides viral vectors, especially vectors derived from adeno-associated virus (AAV), for use in therapeutic delivery of such expression cassettes.Type: GrantFiled: March 23, 2018Date of Patent: April 30, 2024Assignees: THE UNIVERSITY COURT OF THE UNIVERSITY OF EDINBURGH, THE UNIVERSITY COURT OF THE UNIVERSITY OF GLASGOWInventors: Adrian Bird, Rebekah Tillotson, Stuart Robert Cobb, Ralph David Hector
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Publication number: 20210101938Abstract: MeCP2 based therapy. The present invention relates to synthetic polypeptides that are useful in the treatment of disorders associated with reduced MeCP2 activity, including Rett syndrome. The present invention provides synthetic polypeptides comprising: i) an MBD amino acid sequence showing at least 70% similarity with the amino acid sequence showing at least 70% similarity with the amino acid sequence as depicted in SEQ ID NO: 2, wherein the polypeptide has a deletion of at least 50 amino acids, when compared to the full length MeCP2 e1 and e2 sequences. The invention further provides nucleic acid constructs, expression vectors, virions, pharmaceutical compositions, and cells providing polynucleotides of the invention. The invention further provides methods of treating or preventing disease in an animal comprising administering to said animal a synthetic polypeptide according to the invention.Type: ApplicationFiled: March 23, 2018Publication date: April 8, 2021Inventors: Adrian BIRD, Rebekah TILLOTSON, Stuart Robert COBB, Ralph David HECTOR
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Publication number: 20200016279Abstract: The present invention provides nucleic acid molecules comprising a MeCP2 expression cassette, the expression cassette comprising, in operable linkage from 5? to 3?: a 5? transcriptional control region comprising a promoter capable of driving transcription in neural cells; an open reading frame encoding a MeCP2 protein; translation control signals; a 3? untranslated region (3?UTR) comprising one or more of: (i) a binding site for mir-22; (ii) a binding site for mir-19; (iii) a binding site for miR-132; (iv) a binding site for miR124; and (v) an AU-rich element; and transcriptional termination signals; wherein the MeCP2 expression cassette is not more than about 5 kb in length. The invention further provides viral vectors, especially vectors derived from adeno-associated virus (AAV), for use in therapeutic delivery of such expression cassettes.Type: ApplicationFiled: March 23, 2018Publication date: January 16, 2020Inventors: Adrian BIRD, Rebekah TILLOTSON, Stuart Robert COBB, Ralph David HECTOR
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Patent number: 8594924Abstract: An asset operational health monitoring system, in which a plurality of sensors are arranged to determine values of asset operation parameters pertaining to an instance of asset operation. One or more processing unit receives data corresponding to said asset operation values and determine a plurality of asset locations at a corresponding plurality of points in time. The one or more processing unit is arranged to receive data indicative of the location of a region of adverse environmental conditions which may impact on the operation of the asset and to compare the determined locations of the asset with the location of said region so as to determine whether one or more of said asset locations fall within said region. An indicator of operational risk associated with the presence of said asset in said region is output which can drive asset operation or maintenance decision making. The system may be used for ash cloud impact monitoring for aircraft, a fleet of aircraft or aircraft engines.Type: GrantFiled: July 12, 2012Date of Patent: November 26, 2013Assignee: Rolls-Royce, PLCInventors: Stephen P. King, Adrian Bird, Paul A. Flint, Daniel K. Goodall
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Publication number: 20130054056Abstract: An asset operational health monitoring system, in which a plurality of sensors are arranged to determine values of asset operation parameters pertaining to an instance of asset operation. One or more processing unit receives data corresponding to said asset operation values and determine a plurality of asset locations at a corresponding plurality of points in time. The one or more processing unit is arranged to receive data indicative of the location of a region of adverse environmental conditions which may impact on the operation of the asset and to compare the determined locations of the asset with the location of said region so as to determine whether one or more of said asset locations fall within said region. An indicator of operational risk associated with the presence of said asset in said region is output which can drive asset operation or maintenance decision making. The system may be used for ash cloud impact monitoring for aircraft, a fleet of aircraft or aircraft engines.Type: ApplicationFiled: July 12, 2012Publication date: February 28, 2013Applicant: ROLLS-ROYCE PLCInventors: Stephen P. KING, Adrian BIRD, Paul A. FLINT, Daniel K. GOODALL
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Publication number: 20080076671Abstract: The present invention relates to a method of isolating fragments of nucleic acid according to the density of CpG dinucleotides and subsequent procedures for producing a library and/or an array or microarray of these fragments, as well as uses thereof.Type: ApplicationFiled: October 31, 2005Publication date: March 27, 2008Applicant: University Court of the University of EdinburghInventors: Adrian Bird, Robert Illingworth, Helle Jorgensen
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Patent number: D796956Type: GrantFiled: May 27, 2014Date of Patent: September 12, 2017Assignee: Life Technologies CorporationInventors: Paul Clark, Sandro Klein, Xin Mathers, Jeffrey Kelly, David Judd, Scott Glassman, Michael Scribner, Adrian Bird, Imran Mahmood
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Patent number: D796961Type: GrantFiled: January 11, 2016Date of Patent: September 12, 2017Assignee: Life Technologies CorporationInventors: Sandro Klein, Xin Mathers, Pawel Zygier, Adrian Bird
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Patent number: D840826Type: GrantFiled: July 28, 2017Date of Patent: February 19, 2019Assignee: LIFE TECHNOLOGIES CORPORATIONInventors: Paul Clark, Sandro Klein, Xin Mathers, Jeffrey Kelly, David Judd, Scott Glassman, Michael Scribner, Adrian Bird, Imran Mahmood
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Patent number: D901306Type: GrantFiled: February 15, 2019Date of Patent: November 10, 2020Assignee: LIFE TECHNOLOGIES CORPORATIONInventors: Paul Clark, Sandro Klein, Xin Mathers, Jeffrey Kelly, David Judd, Scott Glassman, Michael Scribner, Adrian Bird, Imran Mahmood
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Patent number: D1039382Type: GrantFiled: November 5, 2020Date of Patent: August 20, 2024Assignee: Life Technologies CorporationInventors: Paul Clark, Sandro Klein, Xin Mathers, Jeffrey Kelly, David Judd, Scott Glassman, Michael Scribner, Adrian Bird, Imran Mahmood