Abstract: Screening methods as well as kits for identifying compounds capable of trapping proteins, e.g. proteins involved in DNA repair, are provided. The methods provide the use of live-cell imaging and local laser micro-irradiation of nuclear DNA in an assay to measure the effects of compounds on the trapping of 5 proteins on DNA. The disruption, e.g. inhibition, of specific proteins, such as poly-(ADP-ribose) polymerases or ALC1 enzyme, leads to trapping on chromatin and/or at DNA damage sites. This inhibits essential cellular functions, e.g. DNA damage repair, and can potentiate cancer cell killing.

Abstract: A sealing system has a gasket (25) which in the undeformed state can be placed against a component (1) to be sealed. In the deformed state, the gasket engages the component (1) such that the gasket (25) is captively held on the component (1).

Abstract: A sealing system has a gasket (25) which in the undeformed state can be placed against a component (1) to be sealed and in the deformed state engages the component (1) such that the gasket (25) is captively held on the component (1).