Abstract: The present invention is directed to novel pharmaceutically acceptable polymeric compositions suitable for melt extrusion and injection moulding of single or multi-component pharmaceutical dosage forms comprising a plurality of drug substance containing sub-units, being capsule compartments and/or solid sub-units comprising a solid matrix of a polymer which contains a drug substance, the sub-units being connected together in the assembled dosage form.

Abstract: A bubble and/or water-jet producing bathtub insert is provided according to embodiments of the present invention which includes a flexible sheet material bathtub liner. The bathtub liner has an inner surface and an outer surface and a plurality of passageways between the inner surface and the outer surface. The bathtub insert includes an air and/or water conduit having an air and/or water inlet, a plurality of air and/or water outlets and a wall defining a passage for airflow and/or water flow. The air and/or water conduit is secured to the outer surface of the bathtub liner such that the plurality of air and/or water outlets is generally aligned with the plurality of passageways between the inner surface and the outer surface of the bathtub liner such that air and/or water passing through the air and/or water outlet passes through the bathtub liner.

Abstract: The present invention is directed to novel pharmaceutically acceptable polymeric compositions suitable for melt extrusion and injection molding of single or multi-component pharmaceutical dosage forms comprising a plurality of drug substance containing sub-units, being capsule compartments and/or solid sub-units comprising a solid matrix of a polymer which contains a drug substance, the sub-units being connected together in the assembled dosage form.

Abstract: The present invention is directed to novel pharmaceutically acceptable polymeric compositions suitable for injection molding of single or multi-component pharmaceutical dosage forms comprising a plurality of drug substance containing sub-units, being capsule compartments and/or solid sub-units comprising a solid matrix of a polymer which contains a drug substance, the sub-units being connected together in the assembled dosage form by a weld between parts of the assembled dosage form.

Abstract: A multi-component pharmaceutical dosage form suitable for retaining drug substance can be released to provide a controlled drug release profile in the gastro intestinal environment, characterized by a body e.g. comprising a delayed release polymeric material such as Eudragit 4135F, the body having at least one cavity said cavity having a mouth opening and a film means e.g. comprising an immediate release polymeric material e.g. Eudragit E100 or a blend thereof, connected to the body and closing the mouth opening.

Abstract: The present invention is directed to novel pharmaceutically acceptable polymeric compositions suitable for melt extrusion and injection molding of single or multi-component pharmaceutical dosage forms comprising a plurality of drug substance containing sub-units, being capsule compartments and/or solid sub-units comprising a solid matrix of a polymer which contains a drug substance, the sub-units being connected together in the assembled dosage form.

Abstract: The present invention is directed to novel pharmaceutically acceptable polymeric compositions suitable for injection molding of single or multi-component pharmaceutical dosage forms comprising a plurality of drug substance containing sub-units, being capsule compartments and/or solid sub-units comprising a solid matrix of a polymer which contains a drug substance, the sub-units being connected together in the assembled dosage form by a weld between parts of the assembled dosage form.

Abstract: The present invention is directed to pharmaceutically acceptable polymeric compositions suitable for injection molding of single or multi-component pharmaceutical dosage forms comprising a plurality of drug substance containing sub-units, being capsule compartments and/or solid sub-units comprising a solid matrix of a polymer which contains a drug substance, the sub-units being connected together in the assembled dosage form by a weld between parts of the assembled dosage form.

Abstract: The present invention is directed to pharmaceutically acceptable polymeric compositions suitable for injection molding of single or multi-component pharmaceutical dosage forms comprising a plurality of drug substance containing sub-units, being capsule compartments and/or solid sub-units comprising a solid matrix of a polymer which contains a drug substance, the sub-units being connected together in the assembled dosage form by a weld between parts of the assembled dosage form.

Abstract: The present invention is directed to pharmaceutically acceptable polymeric compositions suitable for injection molding of single or multi-component pharmaceutical dosage forms comprising a plurality of drug substance containing sub-units, being capsule compartments and/or solid sub-units comprising a solid matrix of a polymer which contains a drug substance, the sub-units being connected together in the assembled dosage form by a weld between parts of the assembled dosage form.

Abstract: The present invention is directed to pharmaceutically acceptable polymeric compositions suitable for injection molding of single or multi-component pharmaceutical dosage forms comprising a plurality of drug substance containing sub-units, being capsule compartments and/or solid sub-units comprising a solid matrix of a polymer which contains a drug substance, the sub-units being connected together in the assembled dosage form by a weld between parts of the assembled dosage form.

Abstract: A process is provided for preparing a granular pharmnaceutical ion exchange resin composition that is readily dispersible in water by granulating an ion exchange resin, having a pharmacologically active ingredient bound thereto, with a particulate sugar or sugar alcohol. The process is characterised by the use of an aqueous solution of a sugar or sugar alcohol as a granulating medium.

Abstract: A method for the manufacture of a laxative composition in dosage unit form which comprises the steps of melting a normally solid stool softener; dispersing and/or dissolving a stimulant laxative compound in the molten stool softener and mixing to obtain a uniform mixture; filling the molten dispersion into hard gelatin capsule shells; and allowing the capsules to cool and the melt or dispersion to solidify.

Abstract: A solid oral dosage form comprising diltiazem (or a pharmaceutically acceptable salt thereof) in controlled release form and hydrochlorothiazide in immediate release form. Preferably, the controlled release component comprises a plurality of spheroids comprising diltiazem and a spheronizing agent.

Abstract: In accordance with this invention, a well for soil sparging and soil vapor extraction is provided. The well comprises a bore hole extending from the surface of the earth for several feet and preferably to the base of the clay layer. An impervious casing having a larger diameter than the bore hole is mounted concentrically around the bore hole and extends from a point above the surface of the earth to a point below the surface of the earth. The impervious casing is sealed at its top end by a cover plate. An injection tube is inserted into the bore hole wherein the injection tube terminates at a point above the bottom of the bore hole. The bottom most portion of the bore hole is filled with granular material. Above the granular material, the bore hole is filled with packing material that is substantially impervious to liquid and gas. Above the packing material, the remaining space in the bore hole is filled with permeable material which allows passage of gas or liquid.

Abstract: In accordance with this invention a soil vapor well for removing volatile hydrocarbons from the vadose zone is provided. The well comprises a larger diameter first bore hole extending from the surface of the earth for several feet and preferably to the base of the clay layer, an impervious casing having a smaller diameter than the first bore hole is mounted concentrically within the first bore hole and extends from the bottom of the first bore hole to a point above the surface of the earth. Concrete fills the space between the sides of the first bore hole and the casing to provide a substantially air-tight seal from the earth below the first bore to the surface of the earth. A second bore hole, having a diameter smaller than the diameter of the casing extends downwardly from the lower end of the casing to a point located above the water table. Aggregate fills the second bore hole and the casing.

Abstract: An environmentally acceptable disposal site has at least one vapor break extending through a pile of synthetic fuel tailings, spent catalyst, spent ore, and/or other waste material. The vapor breaks can be permeable seams or columns of porous rocky overburden and/or a pneumatic pipeline. Circulation of air through the vapor breaks can be enhanced by air blowers, fans, or other force air inducers. The top and sides of the pile are covered with top soil and vegetated with trees, shrubbery, and grass to minimize erosion and blowing of the tailings as well as to provide a pleasing aesthetic appearance. The tailings preferably comprise spent oil shale which has been combusted, cooled, and moisturized. Desirably, the disposal site is built and operated in conjunction with a surface retort, combustor, heat recovery unit (cooler), and associated equipment.

Abstract: A process is provided for retorting synthetic fuels, such as oil shale, and disposing of the tailings in an environmentally acceptable manner. In the process, raw synthetic fuels are retorted in a surface retort to produce synthetic oil. The synthetic oil is dedusted and upgraded. The retorted synthetic fuels can be combusted and moisturized to generate heat for the retort, produce steam, and facilitate handling of the residual waste material (tailings). A disposal site of spent synthetic fuels, spent upgrading catalyst, dust, and/or other material is formed with vapor breaks at one or more levels in the pile. Air is passed through the vapor breaks to evaporate leachate rather than permitting the leachate to carry pollutants from the pile into the ground and surrounding bodies of water.