Abstract: A computer-implemented method for 3D reconstruction of a target is provided, comprising obtaining an initial global reconstruction of the target in a 3D space, inferred by a global machine learning model; providing, to a user, an initial visualisation of the target based on the reconstruction; receiving, from the user, at least one indication of at least one point of interest in the visualisation; resampling at least one first subsection of the target based on the at least one point of interest to obtain local data, wherein the local data is associated with the subsection based on spatial information that associates the local data with a point in 3D space; inputting the resampled local data and spatial information into a local feature machine learning model to obtain at least one 3D reconstruction of the target, wherein the local feature machine learning model has been trained to output a target reconstruction from local data of resampled subsections, and wherein the 3D coordinate system of the local 3D recon

Abstract: Aspects of the present invention provide machine colour characterisation for augmented reality. A process of machine colour characterisation for digital images comprises generating colour model data for each of a set of colour categories dependent on colour captured in example digital media from example colours in an example image, the colour model data for each colour category defining a constraint in a colour space. The constraint is defined dependent on a set of example pixels of the example digital media, and the process comprising relating pixels of the image to be characterised to the constraint of one or more colour models to identify colour categories for the pixels of the image to be characterized to characterise the digital image. A transformation is computed for a mean of the example pixels expressed using colour components to the origin of the R, G, B cube and transforms one or more axes determined for the pixels to align with R, G or B axes. A constraint may be defined as a first bounding volume.

Abstract: The invention relates to a head support system for a stretcher. The invention provides a base support (1) and head block (11) which can be applied to a stretcher in order to restrict movement of a patient's head.

Abstract: The invention relates to a novel process for the preparation of certain cyclopropyl carboxylic acid esters and other cyclopropyl carboxylic acid derivatives; a novel process for the preparation of dimethylsulfoxonium methylide and dimethylsulfonium methylide; to the use of certain cyclopropyl carboxylic acid esters in a process for the preparation of intermediates that can be used in the synthesis of pharmaceutically active entities; and to certain intermediates provided by these processes.

Abstract: The invention relates to a novel process for the preparation of certain cyclopropyl carboxylic acid esters and other cyclopropyl carboxylic acid derivatives; a novel process for the preparation of dimethylsulfoxonium methylide and dimethylsulfonium methylide; to the use of certain cyclopropyl carboxylic acid esters in a process for the preparation of intermediates that can be used in the synthesis of pharmaceutically active entities; and to certain intermediates provided by these processes.

Abstract: The invention relates to a novel process for the preparation of certain cyclopropyl carboxylic acid esters and other cyclopropyl carboxylic acid derivatives; a novel process for the preparation of dimethylsulfoxonium methylide and dimethylsulfonium methylide; to the use of certain cyclopropyl carboxylic acid esters in a process for the preparation of intermediates that can be used in the synthesis of pharmaceutically active entities; and to certain intermediates provided by these processes.

Abstract: The compounds trans-(1R,2R)-2-(3,4-difluorophenyl)cyclopropanecarbonyl azide and trans-(1R,2S)-2-(3,4-difluorophenyl)cyclopropanaminium (2R)-2-hydroxy-2-phenylethanoate.

Abstract: The invention relates to a novel process for the preparation of certain cyclopropyl carboxylic acid esters and other cyclopropyl carboxylic acid derivatives; a novel process for the preparation of dimethylsulfoxonium methylide and dimethylsulfonium methylide; to the use of certain cyclopropyl carboxylic acid esters in a process for the preparation of intermediates that can be used in the synthesis of pharmaceutically active entities; and to certain intermediates provided by these processes.

Abstract: The invention relates to a novel process for the preparation of certain cyclopropyl carboxylic acid esters and other cyclopropyl carboxylic acid derivatives; a novel process for the preparation of dimethylsulfoxonium methylide and dimethylsulfonium methylide; to the use of certain cyclopropyl carboxylic acid esters in a process for the preparation of intermediates that can be used in the synthesis of pharmaceutically active entities; and to certain intermediates provided by these processes.

Abstract: The invention relates to a novel process for the preparation of certain cyclopropyl carboxylic acid esters and other cyclopropyl carboxylic acid derivatives; a novel process for the preparation of dimethylsulfoxonium methylide and dimethylsulfonium methylide; to the use of certain cyclopropyl carboxylic acid esters in a process for the preparation of intermediates that can be used in the synthesis of pharmaceutically active entities; and to certain intermediates provided by these processes.