Abstract: The present disclosure relates to methods of differentiating pluripotent stem cells into endothelial cells. The present disclosure also relates to endothelial cells made by such methods, organoids containing such endothelial cells, and methods of use thereof. The present disclosure also relates to differentiation media for use in the same.

Abstract: The present disclosure relates to methods of differentiating pluripotent stem cells or lung progenitor cells into epithelial or basal cells. The present disclosure also relates to epithelial or basal cells made by such methods, organoids containing such epithelial or basal cells, and methods of using the same. The present disclosure also relates to differentiation media for use in the same.

Abstract: The present disclosure relates to methods of differentiating pluripotent stem cells or lung progenitor cells into alveolar type 2 (AT2) cells. The present disclosure also relates to AT2 cells made by such methods, organoids containing such AT2 cells and methods of using the same. The present disclosure also relates to differentiation media for use in the same.

Abstract: A spark ignited engine is disclosed. The spark ignited engine includes a main combustion chamber and a cylinder head at least partially surrounding the main combustion chamber. A spark plug having a central axis is arranged in the cylinder head and an ignition end of the spark plug faces the main combustion engine. A pre-chamber with at least two nozzles is arranged in the main combustion chamber and connects the ignition end and the main combustion chamber via the at least two nozzles. A pre-chamber volume ratio corresponds to a ratio of a volume of the pre-chamber to a volume of the main combustion chamber at a top-dead-center and is between 1.9% and 3.1%. A nozzle factor corresponds to a ratio of a summed flowed-through area of the at least two nozzles to the volume of the pre-chamber and is between 0.085 l/cm and 1.15 l/cm.

Abstract: A spark ignited engine is disclosed. The spark ignited engine includes a main combustion chamber and a cylinder head at least partially surrounding the main combustion chamber. A spark plug having a central axis is arranged in the cylinder head and an ignition end of the spark plug faces the main combustion engine. A pre-chamber with at least two nozzles is arranged in the main combustion chamber and connects the ignition end and the main combustion chamber via the at least two nozzles. A pre-chamber volume ratio corresponds to a ratio of a volume of the pre-chamber to a volume of the main combustion chamber at a top-dead-center and is between 1.9% and 3.1%. A nozzle factor corresponds to a ratio of a summed flowed-through area of the at least two nozzles to the volume of the pre-chamber and is between 0.085 l/cm and 1.15 l/cm.

Abstract: The invention relates to a cartridge housing for forming a cartridge capable of measuring an analyte or property of a liquid sample. The housing including a top portion having a first substantially rigid zone and a substantially flexible zone, a bottom portion separate from the top portion including a second substantially rigid zone, and at least one sensor recess containing a sensor. The top portion and the bottom portion are bonded to form the cartridge having a conduit over at least a portion of the sensor. The invention also relates to methods for forming such cartridges and to various features of such cartridges.

Abstract: The invention relates to a cartridge housing for forming a cartridge capable of measuring an analyte or property of a liquid sample. The housing including a top portion having a first substantially rigid zone and a substantially flexible zone, a bottom portion separate from the top portion including a second substantially rigid zone, and at least one sensor recess containing a sensor. The top portion and the bottom portion are bonded to form the cartridge having a conduit over at least a portion of the sensor. The invention also relates to methods for forming such cartridges and to various features of such cartridges.

Abstract: The invention relates to a cartridge housing for forming a cartridge capable of measuring an analyte or property of a liquid sample. The housing including a top portion having a first substantially rigid zone and a substantially flexible zone, a bottom portion separate from the top portion including a second substantially rigid zone, and at least one sensor recess containing a sensor. The top portion and the bottom portion are bonded to form the cartridge having a conduit over at least a portion of the sensor. The invention also relates to methods for forming such cartridges and to various features of such cartridges.

Abstract: The invention relates to a cartridge housing for forming a cartridge capable of measuring an analyte or property of a liquid sample. The housing including a top portion having a first substantially rigid zone and a substantially flexible zone, a bottom portion separate from the top portion including a second substantially rigid zone, and at least one sensor recess containing a sensor. The top portion and the bottom portion are bonded to form the cartridge having a conduit over at least a portion of the sensor. The invention also relates to methods for forming such cartridges and to various features of such cartridges.

Abstract: The invention relates to a cartridge housing for forming a cartridge capable of measuring an analyte or property of a liquid sample. The housing including a top portion having a first substantially rigid zone and a substantially flexible zone, a bottom portion separate from the top portion including a second substantially rigid zone, and at least one sensor recess containing a sensor. The top portion and the bottom portion are bonded to form the cartridge having a conduit over at least a portion of the sensor. The invention also relates to methods for forming such cartridges and to various features of such cartridges.

Abstract: A clutch mechanism 5 for use with a carrier of a linear drive device 1, where the mechanism 5 includes: a housing 3; a first gear 6 coupled to the housing 3 and having gear teeth 61 configured to engage a threaded shaft 2 of a linear drive device 1, so that rotation of the shaft 2 causes the housing 3 to move along the shaft 2 in a first mode of operation; and a first clutch arrangement associated with the first gear 6 and configured to prevent substantial rotation of the first gear 6 with respect to the housing 3 when a rotational force applied to the first gear 6 is less than a threshold force and to permit rotation of the first gear 6 with respect to the housing 3 when a rotational force applied to the first gear 6 is greater than the threshold force.

Abstract: The invention relates to a cartridge housing for forming a cartridge capable of measuring an analyte or property of a liquid sample. The housing comprising a first substantially rigid zone, a second substantially flexible zone, a hinge region, and at least one sensor recess containing a sensor. The housing is foldable about said hinge region to form a cartridge having a conduit over at least a portion of said sensor. The invention also relates to methods for forming such cartridges and to various features of such cartridges.

Abstract: The present invention is a telescopic drive device of a device for holding a surgical instrument. The telescopic drive device includes a support; a first telescopic stage carried by the support; a first telescopic stage carried by the support, the first telescopic stage being able to perform a first motion with respect to the support; a second telescopic stage, which is able to perform a second motion with respect to the first telescopic stage; and a drive system, which is operable to drive the first and second motions. The first telescopic element performs the first motion and the second telescopic element simultaneously performs the second motion. The telescopic drive is operable to support a further device and to move the further device such that the movement is centered around a point or wherein each of the telescopic elements is arcuate.

Abstract: The invention relates to a cartridge housing for forming a cartridge capable of measuring an analyte or property of a liquid sample. The housing comprising a first substantially rigid zone, a second substantially flexible zone, a hinge region, and at least one sensor recess containing a sensor. The housing is foldable about said hinge region to form a cartridge having a conduit over at least a portion of said sensor. The invention also relates to methods for forming such cartridges and to various features of such cartridges.

Abstract: A clutch mechanism 5 for use with a carrier of a linear drive device 1, the mechanism 5 comprising: a housing 3; a first gear 6 coupled to the housing 3 and having gear teeth 61 configured to engage a threaded shaft 2 of a linear drive device 1, such that rotation of the shaft 2 causes the housing 3 to move along the shaft 2 in a first mode of operation; and a first clutch arrangement associated with the first gear 6 and configured to prevent substantial rotation of the first gear 6 with respect to the housing 3 when a rotational force applied to the first gear 6 is less than a threshold force and to permit rotation of the first gear 6 with respect to the housing 3 when a rotational force applied to the first gear 6 is greater than the threshold force, such that the housing 3 can be manually moved along a length of the shaft 2, in a second mode of operation, by exerting a force on the housing 2 such that the rotational force applied to the first gear 6 through the interaction of the threaded shaft 2 and the g

Abstract: The invention relates to a cartridge housing for forming a cartridge capable of measuring an analyte or property of a liquid sample. The housing comprising a first substantially rigid zone, a second substantially flexible zone, a hinge region, and at least one sensor recess containing a sensor. The housing is foldable about said hinge region to form a cartridge having a conduit over at least a portion of said sensor. The invention also relates to methods for forming such cartridges and to various features of such cartridges.

Abstract: A clutch mechanism for use with a carrier of a linear drive device includes a housing, a first gear, and a first clutch arrangement. The first gear coupled to the housing and has gear teeth to engage a threaded shaft of a linear drive device . Rotation of the shaft causes the housing to move along the shaft in a first mode of operation. The first clutch arrangement prevents substantial rotation of the first gear. The first gear permits rotation of the first gear with respect to the housing. The housing can be manually moved along a length of the shaft, in a second mode of operation, by exerting a force on the housing. The rotational force applied to the first gear through the interaction of the threaded shaft and the gear teeth exceeds the first threshold.

Abstract: The invention relates to a cartridge housing for forming a cartridge capable of measuring an analyte or property of a liquid sample. The housing including a top portion having a first substantially rigid zone and a substantially flexible zone, a bottom portion separate from the top portion including a second substantially rigid zone, and at least one sensor recess containing a sensor. The top portion and the bottom portion are bonded to form the cartridge having a conduit over at least a portion of the sensor. The invention also relates to methods for forming such cartridges and to various features of such cartridges.

Abstract: The invention relates to a cartridge housing for forming a cartridge capable of measuring an analyte or property of a liquid sample. The housing comprising a first substantially rigid zone, a second substantially flexible zone, a hinge region, and at least one sensor recess containing a sensor. The housing is foldable about said hinge region to form a cartridge having a conduit over at least a portion of said sensor. The invention also relates to methods for forming such cartridges and to various features of such cartridges.