Abstract: A system for monitoring the exposure of a plurality of individuals to a physical or chemical property associated with an environment. The system includes a plurality of portable devices. Each portable device is arranged to be worn or carried by an individual in the environment. The system further includes a control unit for communicating with each of the plurality of portable devices. Each portable device includes a detector arranged to measure a physical or chemical property that the individual wearing or carrying the device is exposed to in the environment; one or more physiological sensors each arranged to measure a physiological parameter of the individual; a geolocation module arranged to determine the location of the individual; and a communication module for communicating data collected by the portable device with other(s) of the plurality of the portable devices and with the control unit.

Abstract: A decontamination apparatus for decontaminating an external surface is provided. The decontamination apparatus has a moveable platform and a containment structure mounted on the moveable platform. The containment structure has at least one aperture and a respective contact surface arranged around the perimeter of the aperture. The contact surface is arranged to make contact with the external surface to define a working volume, when the containment structure is positioned proximal to the external surface. The decontamination apparatus includes a decontamination device arranged to decontaminate the external surface. The decontamination device is arranged within the working volume and arranged to access the external surface through the at least one aperture. There is also a vacuum system for generating a partial vacuum in the containment structure to apply a suction force to the external surface.

Abstract: The present invention provides a composition for topical administration of a polyhydroxy acid, such as lactobionate and especially zinc lactobionate, and low pH to an external body surface such as skin. The composition is designed to be highly effective in delivering low pH and zinc lactobionate across the layers of the skin to more effectively treat and prevent skin conditions involving a defective skin barrier such as eczema and severe dry skin.

Abstract: A composition for topical dermatological delivery of a medicinal or cosmeceutical or cosmetic active including a functional co-enhancer delivery system comprises a primary active agent in combination with an ancillary user adherence-improving skin barrier restoring system comprising nicotinamide and polyhydroxy acid. The composition generally comprises a water-miscible solvent and C12 or C14 fatty acids or C14 alcohol in combination with a hydrocarbyl methyl siloxane, other volatile silicones and a blend of silicone elastomers.

Abstract: There is described a topical composition for application of an NSAID comprising ibuprofen, the composition comprising a solution or suspension of the NSAID as active ingredient in a residual carrier system comprising a polyhydric alcohol, a glycol ether, an ester of a higher fatty acid and optionally water, the ingredients of the residual carrier system having the following concentrations in percentages by weight: polyhydric alcohol 50-90 glycol ether 7.5-40 ester 0.5-5 water optional in which either the composition or the residual phase is in a single phase under ambient conditions and the maximum water concentration is that above which the composition or the residual phase exhibits signs of inhomogeneity.

Abstract: The present invention provides a composition for topical administration of a polyhydroxy acid, such as lactobionate and especially zinc lactobionate, and low pH to an external body surface such as skin. The composition is designed to be highly effective in delivering low pH and zinc lactobionate across the layers of the skin to more effectively treat and prevent skin conditions involving a defective skin barrier such as eczema and severe dry skin.

Abstract: A system for monitoring the exposure of a plurality of individuals to a physical or chemical property associated with an environment. The system includes a plurality of portable devices. Each portable device is arranged to be worn or carried by an individual in the environment. The system further includes a control unit for communicating with each of the plurality of portable devices. Each of the portable device includes a detector arranged to measure a physical or chemical property that the individual wearing or carrying the device is exposed to in the environment; one or more physiological sensors each arranged to measure a physiological parameter of the individual; a geolocation module arranged to determine the location of the individual; and a communication module for communicating data collected by the portable device with other(s) of the plurality of the portable devices and with the control unit.

Abstract: There is described a composition for topical application to the penis for treatment of erectile dysfunction, the composition comprising glyceryl trinitrate (GTN) as active ingredient dissolved in a blend of volatile and non-volatile solvents of different solvating capacities for the GTN, in which the volatile solvents comprise water and a lower alcohol and the non-volatile solvents comprise a polyhydric alcohol and a glycol having a ratio by weight of from 1.5:1 to 6.0:1, in which the composition has a pH as manufactured in the range 5.1 to 7.0. Also described is the use of the composition and methods involving the composition for treating or ameliorating erectile dysfunction.

Abstract: A formulation for topical dermatological delivery of a medicinal or cosmeceutical or cosmetic active including a functional co-enhancer delivery system. The delivery system generally comprises a water-miscible solvent and C12 or C14 fatty acids or C14 alcohol in combination with a hydrocarbyl methyl siloxane emollient.

Abstract: This invention relates to lentiviral gene transfer vectors pseudotyped with hemagglutinin-neuraminidase (HN) and fusion (F) proteins from a respiratory paramyxovirus, comprising a promoter and a transgene; and methods of making the same. The present invention also relates to the use of said vectors in gene therapy, particularly for the treatment of respiratory tract diseases such as Cystic Fibrosis (CF).

Abstract: There is described a topical composition for application of an NSAID comprising ibuprofen, the composition comprising a solution or suspension of the NSAID as active ingredient in a residual carrier system comprising a polyhydric alcohol, a glycol ether, an ester of a higher fatty acid and optionally water, the ingredients of the residual carrier system having the following concentrations in percentages by weight: polyhydric alcohol 50-90 glycol ether 7.5-40 ester 0.5-5 water optional in which either the composition or the residual phase is in a single phase under ambient conditions and the maximum water concentration is that above which the composition or the residual phase exhibits signs of inhomogeneity.

Abstract: Herein described is a topical composition for application of an NSAID, the composition comprising a solution or suspension of the NSAID as active ingredient in a residual carrier system comprising a polyhydric alcohol, a glycol ether, an ester of a higher fatty acid and water, and the ingredients of the residual carrier system have the following concentrations in percentages by weight::polyhydric alcohol 50-90%; glycol ether 7.5-40%; ester 0.5-5%; and water up to 10%. Either the composition or the residual carrier system is a single phase at ambient conditions. The composition may also comprise a volatile solvent such as ethanol or isopropyl alcohol.

Abstract: A formulation for topical dermatological delivery of a medicinal or cosmeceutical or cosmetic active including a functional co-enhancer delivery system. The delivery system generally comprises a water-miscible solvent and C12 or C14 fatty acids or C14 alcohol in combination with a hydrocarbyl methyl siloxane emollient.

Abstract: This invention relates to lentiviral gene transfer vectors pseudotyped with hemagglutinin-neuraminidase (HN) and fusion (F) proteins from a respiratory paramyxovirus, comprising a promoter and a transgene; and methods of making the same. The present invention also relates to the use of said vectors in gene therapy, particularly for the treatment of respiratory tract diseases such as Cystic Fibrosis (CF).

Abstract: A composition comprising a pharmaceutically acceptable group (2, 4, 12, 13 or 14) metal compound for the treatment of a dermatological condition involving an abnormal decrease in the cell-to-cell adhesion between epithelial cells in the epidermal barrier.

Abstract: An antimicrobial and/or anti-acne formulation containing either usnic acid or an usnate, together with (a) a primary solvent or solvent system in which the usnic acid or usnate is at least partially dissolved; (b) a glycol; and (c) a hydrophobic fatty acid, fatty alcohol or derivative thereof. The formulation may also contain (d) an alkylene glycol derivative.

Abstract: Methods are described of delivering biological material, which methods include the steps of providing a liquid formulation containing the biological material, supplying the liquid formulation to an outlet and subjecting liquid issuing from the outlet to an electrical field thereby causing electrohydrodynamic processing of the liquid without denaturing the biological material. In one example, the liquid formulation is provided by removing salts from a formulation containing biological material that does not denature in alcohol and then adding an alcohol to the formulation before supplying the liquid formulation to the outlet. An acid may be added to the liquid formulation before supplying the liquid formulation to the outlet.

Abstract: The present invention provides a composition for topical administration to the skin for treating and/or preventing a dermatological condition involving an abnormal decrease in the cell-to-cell adhesion between epithelial cells comprising a zinc salt which is at least partially soluble in water and an acid, wherein the composition has a pH less than or equal to 6. The dermatological condition is generally selected from eczema, dermatitis, atopic eczema, atopic dermatitis, non-atopic eczema, non-atopic dermatitis, seborrheic eczema, irritant contact dermatitis, allergic contact dermatitis, pruritus and sensitive skin. A preferred composition comprises zinc lactate, lactic acid and has a pH of about 4.0 to 5.0.

Abstract: A composition comprising a pharmaceutically acceptable group (2, 4, 12, 13 or 14) metal compound for the treatment of a dermatological condition involving an abnormal decrease in the cell-to-cell adhesion between epithelial cells in the epidermal barrier.

Abstract: A portable electronic device carrier (100) includes a base (105) having a resting portion (110) which slidably receives an electronic device (200) for securing the electronic device in a stored position. The base further includes a projection (120) extending from the base and positioned to engage the electronic device where the projection selectively alters the state of the electronic device when the electronic device is removed from the stored position along a first path (300) and fails to alter the state of the electronic device when the electronic device is removed along a second path (400).