Abstract: Disclosed herein are pyrazole pyrimidine compounds that modulate and/or inhibit hematopoietic progenitor kinase 1, as well as methods of making such compounds and therapeutic methods of using same.

Abstract: A portal for multiplayer virtual reality games implemented using a portable space is described. The portal comprises a control room; and an arena. The arena accommodates players, and comprises input subsystems. The input subsystems receive game-related inputs from the players, and transmit input signals to a gaming control subsystem. The arena comprises immersive effects subsystems. Based on at least one of the gaming control subsystem executing programs and the received input signals, the gaming control subsystem transmits immersive effects signals to the immersive effects subsystems, which then produce immersive effects for the players. The arena comprises audiovisual output subsystems. Based on at least one of the gaming control subsystem executing programs using data and the received input signals, the gaming control subsystem transmits output signals to audiovisual output subsystems, which then produce audiovisual outputs for the players based on the output signals.

Abstract: A system for immersive effects in a portal implemented using a portable space for multiplayer virtual reality games. The portal comprises a control room and arenas in proximity to, and communicatively coupled to the control room. Each of the arenas accommodates one or more players, and comprises immersive effects subsystems communicatively coupled to a gaming control subsystem. The immersive effects subsystems receive immersive effects signals from the gaming control subsystem, and produces immersive effects for the players based on the immersive effects signals. The gaming control subsystem receives input signals from communicatively coupled input subsystems, which were generated by the input subsystems based on receiving game-related inputs. The gaming control subsystem generates the immersive effects signals based on at least one of: the gaming control subsystem executing programs related to the game, and the gaming control subsystem processing the input signals received from the input subsystems.

Abstract: Disclosed herein are pyrazole pyrimidine compounds that modulate and/or inhibit hematopoietic progenitor kinase 1, as well as methods of making such compounds and therapeutic methods of using same.