Patents by Inventor Adrian E. Smith
Adrian E. Smith has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20030094173Abstract: An aerosolization apparatus comprises a body having an inlet, an endpiece having an outlet, the endpiece being connectable to the body to define a chamber, wherein the chamber is sized to receive a capsule containing a pharmaceutical formulation in a manner which allows the capsule to move within the chamber. A connection mechanism is provided to provide selective connection of the endpiece to the body, and a locking member prevents undesired disconnection of the endpiece from the body. When a user inhales, air enters into the chamber through the inlet so that the pharmaceutical formulation is aerosolized within the chamber and the aerosolized pharmaceutical formulation is delivered to the user through the outlet. In another version, the endpiece and the body are hinged together.Type: ApplicationFiled: November 14, 2002Publication date: May 22, 2003Applicant: Inhale Therapeutic Systems, Inc.Inventors: John D. Burr, Jeff R. Wood, Adrian E. Smith, John A. Howard
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Patent number: 6546929Abstract: The invention provides various apparatus and methods for aerosolizing a powdered medicament. In one exemplary embodiment, an apparatus includes a pressurization cylinder, and a piston which is slidable within the cylinder to pressurize a gas. A handle is coupled to the piston and is movable between an extended position and a home position to pressurize the gas. An aerosolizing mechanism is included and is configured to aerosolize a powdered medicament that is held within a receptacle with pressurized gas from the cylinder. A carriage assembly is included to receive the receptacle and to couple the receptacle to the aerosolizing mechanism. A first and a second interlock are operably engageable with the carriage assembly to prevent coupling of the receptacle with the aerosolization mechanism. The first interlock is released to allow movement of the carriage upon movement of the handle to the extended position.Type: GrantFiled: June 4, 2001Date of Patent: April 15, 2003Assignee: Inhale Therapeutic Systems, Inc.Inventors: John D. Burr, Adrian E. Smith, Randy K. Hall, Herman Snyder, Carlos Schuler, George S. Axford, Charles Ray
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Patent number: 6543448Abstract: A method for aerosolizing a powdered medicament comprises coupling a powder inlet end of a feed tube with a penetration in a receptacle containing the powder. Powder is drawn upward through the tube and dispersed in a high pressure gas stream flowing past a portion of the feed tube. Apparatus comprise the feed tube mounted within a base enclosure proximate a holder for one or more receptacles, which may be in the form of a cartridge containing a plurality of receptacles formed in a continuous web. The cartridge may be reciprocated relative to the feed tube and a separate piercing mechanism in order to sequentially piercing the receptacle and thereafter couple the feed tube through the resulting penetration for extracting the powder. Alternatively, penetration(s) through the receptacle may be formed as the feed tube is coupled, or some penetrations formed prior to coupling with other penetrations formed at the time of coupling.Type: GrantFiled: May 30, 2000Date of Patent: April 8, 2003Assignee: Inhale Therapeutic Systems, Inc.Inventors: Adrian E. Smith, John D. Burr, Jeffrey W. Etter, George S. Axford, Jack M. Anthony
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Publication number: 20020148527Abstract: The invention provides methods, systems and apparatus for the metered transport of fine powders into receptacles. According to one exemplary method, the fine powder is first fluidized. At least a portion of the fluidized fine powder is then captured. The captured fine powder is then transferred to a receptacle, with the transferred powder being sufficiently uncompacted so that it may be dispersed upon removal from the receptacle.Type: ApplicationFiled: May 28, 2002Publication date: October 17, 2002Inventors: Derrick J. Parks, Michael J. Rocchio, Kyle Naydo, Dennis E. Wightman, Adrian E. Smith
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Publication number: 20020071871Abstract: The present invention is directed to particles, including liquid droplets and dry particulates, having a narrow particle size distribution made from a liquid feed stock. In particular, the invention is directed to producing particles of a desired median diameter and narrow particle size distribution without the need for additional separation processing. The process of the present invention can be tailored to produce substantially monodisperse particles or multimodal particles having well defined and controllable particle size distributions. The present invention is particularly well suited for producing particles for pulmonary administration.Type: ApplicationFiled: July 31, 2001Publication date: June 13, 2002Inventors: Herm Snyder, Adrian E. Smith, Jim Nasiatka
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Publication number: 20020017297Abstract: The invention provides various apparatus and methods for aerosolizing a powdered medicament. In one exemplary embodiment, an apparatus includes a pressurization cylinder, and a piston which is slidable within the cylinder to pressurize a gas. A handle is coupled to the piston and is movable between an extended position and a home position to pressurize the gas. An aerosolizing mechanism is included and is configured to aerosolize a powdered medicament that is held within a receptacle with pressurized gas from the cylinder. A carriage assembly is included to receive the receptacle and to couple the receptacle to the aerosolizing mechanism. A first and a second interlock are operably engageable with the carriage assembly to prevent coupling of the receptacle with the aerosolization mechanism. The first interlock is released to allow movement of the carriage upon movement of the handle to the extended position.Type: ApplicationFiled: June 4, 2001Publication date: February 14, 2002Inventors: John D. Burr, Adrian E. Smith, Randy K. Hall, Herman Snyder, Carlos Schuler, George S. Axford, Charles Ray
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Publication number: 20010047837Abstract: The invention provides methods, systems and apparatus for the metered transport of fine powders into receptacles. According to one exemplary method, the fine powder is first fluidized. At least a portion of the fluidized fine powder is then captured. The captured fine powder is then transferred to a receptacle, with the transferred powder being sufficiently uncompacted so that it may be dispersed upon removal from the receptacle.Type: ApplicationFiled: June 4, 2001Publication date: December 6, 2001Inventors: Derrick J. Parks, Michael J. Rocchio, Kyle Naydo, Dennis E. Wightman, Adrian E. Smith
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Patent number: 6267155Abstract: Methods, systems and apparatus for the metered transport of fine powders into receptacles. According to one exemplary method, the fine powder is first fluidized. At least a portion of the fluidized fine powder is then captured. The captured fine powder is then transferred to a receptacle, with the transferred powder being sufficiently uncompacted so that it may be dispersed upon removal from the receptacle.Type: GrantFiled: September 3, 1998Date of Patent: July 31, 2001Assignee: Inhale Therapeutic Systems Inc.Inventors: Derrick J. Parks, Michael J. Rocchio, Kyle Naydo, Dennis E. Wightman, Adrian E. Smith
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Patent number: 6257233Abstract: The invention provides various apparatus and methods for aerosolizing a powdered medicament. In one exemplary embodiment, an apparatus includes a pressurization cylinder, and a piston which is slidable within the cylinder to pressurize a gas. A handle is coupled to the piston and is movable between an extended position and a home position to pressurize the gas. An aerosolizing mechanism is included and is configured to aerosolize a powdered medicament that is held within a receptacle with pressurized gas from the cylinder. A carriage assembly is included to receive the receptacle and to couple the receptacle to the aerosolizing mechanism. A first and a second interlock are operably engageable with the carriage assembly to prevent coupling of the receptacle with the aerosolization mechanism. The first interlock is released to allow movement of the carriage upon movement of the handle to the extended position.Type: GrantFiled: May 14, 1999Date of Patent: July 10, 2001Assignee: Inhale Therapeutic SystemsInventors: John D. Burr, Adrian E. Smith, Randy K. Hall, Herman Snyder, Carlos Schuler, George S. Axford, Charles Ray
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Patent number: 6089228Abstract: A method for aerosolizing a powdered medicament comprises coupling a powder inlet end of a feed tube with a penetration in a receptacle containing the powder. Powder is drawn upward through the tube and dispersed in a high pressure gas stream flowing past a portion of the feed tube. Apparatus comprise the feed tube mounted within a base enclosure proximate a holder for one or more receptacles, which may be in the form of a cartridge containing a plurality of receptacles formed in a continuous web. The cartridge may be reciprocated relative to the feed tube and a separate piercing mechanism in order to sequentially piercing the receptacle and thereafter couple the feed tube through the resulting penetration for extracting the powder. Alternatively, penetration(s) through the receptacle may be formed as the feed tube is coupled, or some penetrations formed prior to coupling with other penetrations formed at the time of coupling.Type: GrantFiled: January 8, 1998Date of Patent: July 18, 2000Assignee: Inhale Therapeutic SystemsInventors: Adrian E. Smith, John D. Burr, Jeffrey W. Etter, George S. Axford, Jack M. Anthony
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Patent number: 5826633Abstract: Methods, systems and apparatus for the metered transport of fine powders into receptacles are provided. According to one exemplary method, the fine powder is first fluidized. At least a portion of the fluidized fine powder is then captured. The captured fine powder is then transferred to a receptacle, with the are provided transferred powder being sufficiently uncompacted so that it may be dispersed upon removal from the receptacle.Type: GrantFiled: April 26, 1996Date of Patent: October 27, 1998Assignee: Inhale Therapeutic SystemsInventors: Derrick J. Parks, Michael J. Rocchio, Kyle Naydo, Dennis E. Wightman, Adrian E. Smith
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Patent number: 5785049Abstract: A method for aerosolizing a powdered medicament comprises coupling a powder inlet end of a feed tube with a penetration in a receptacle containing the powder. Powder is drawn upward through the tube and dispersed in a high pressure gas stream flowing past a portion of the feed tube. Apparatus comprise the feed tube mounted within a base enclosure proximate a holder for one or more receptacles, which may be in the form of a cartridge containing a plurality of receptacles formed in a continuous web. The cartridge may be reciprocated relative to the feed tube and a separate piercing mechanism in order to sequentially piercing the receptacle and thereafter couple the feed tube through the resulting penetration for extracting the powder. Alternatively, penetration(s) through the receptacle may be formed as the feed tube is coupled, or some penetrations formed prior to coupling with other penetrations formed at the time of coupling.Type: GrantFiled: September 21, 1994Date of Patent: July 28, 1998Assignee: Inhale Therapeutic SystemsInventors: Adrian E. Smith, John D. Burr, Jeffery W. Etter, George S. Axford, Shirley W. Lyons, Robert M. Platz
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Patent number: 5740794Abstract: A method for aerosolizing a powdered medicament comprises coupling a powder inlet end of a feed tube with a penetration in a receptacle containing the powder. Powder is drawn upward through the tube and dispersed in a high pressure gas stream flowing past a portion of the feed tube. Apparatus comprise the feed tube mounted within a base enclosure proximate a holder for one or more receptacles, which may be in the form of a cartridge containing a plurality of receptacles formed in a continuous web. The cartridge may be reciprocated relative to the feed tube and a separate piercing mechanism in order to sequentially piercing the receptacle and thereafter couple the feed tube through the resulting penetration for extracting the powder. Alternatively, penetration(s) through the receptacle may be formed as the feed tube is coupled, or some penetrations formed prior to coupling with other penetrations formed at the time of coupling.Type: GrantFiled: June 7, 1995Date of Patent: April 21, 1998Assignee: Inhale Therapeutic SystemsInventors: Adrian E. Smith, John D. Burr, Jeffrey W. Etter, George S. Axford, Jack M. Anthony
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Patent number: D390651Type: GrantFiled: December 12, 1996Date of Patent: February 10, 1998Assignee: Inhale Therapeutics SystemsInventors: Adrian E. Smith, John D. Burr, Jeffrey W. Etter, George S. Axford