Abstract: A method can include receiving strain data associated with propagation of a hydraulic fracture in a subsurface geologic region; performing a comparison between the strain data and simulation results generated using a mesh model of the subsurface geologic region and enrichment equations that represent one or more discontinuities in the subsurface geologic region; and, based on the comparison, characterizing the subsurface geologic region.

Abstract: The present invention provides for methods for identifying modulators of extracellular matrix (ECM) movement towards a site requiring deposition of ECM. Such modulators can be applied for use in a method for the modulation of ECM movement towards a site requiring deposition of ECM, e.g. a wound, thereby allowing treatment of a condition involving ECM deposition. Since the modulator may either be an inhibitor or promoter, either excessive or insufficient ECM deposition could be dealt with by the means and methods of the present invention.

Abstract: The present invention relates to a compound for use in a method of reducing the formation of heliocytes causing adhesiogenesis. An in vitro assay for the formation of heliocyte and/or the formation of adhesions is also comprised herein, as well as methods comprising the use of said in vitro assay. It also relates to a pharmaceutical composition for use in a method of reducing the formation of heliocytes comprising the compound mentioned above.