Patents by Inventor Adrian Francis Davis
Adrian Francis Davis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9358219Abstract: A pharmaceutical composition comprises an active ingredient dissolved in an essentially non-aqueous carrier system comprising volatile and non-volatile components, in which the volatile component comprises a volatile non-solvent for the active ingredient and a volatile solvation additive for the non-solvent and the non-volatile component comprises a non-volatile non-solvent and optionally a non-volatile solvent for the active ingredient, the volatile and non-volatile non-solvents comprising silicone fluids of respectively different viscosity.Type: GrantFiled: November 10, 2010Date of Patent: June 7, 2016Assignee: Futura Medical Developments LimitedInventor: Adrian Francis Davis
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Patent number: 9265721Abstract: A composition for topical application to a part of the body comprises a local anaesthetic and optionally a vasodilator as active ingredient dissolved in a blend of volatile and non-volatile solvents of different solvating capacities for the active ingredient. The vasodilator may comprise glyceryl trinitrate and the local anaesthetic may comprises an anaesthetic of the aminoamide or aminoester type. The volatile solvent may comprise a mixture of water with a C1-C5 alcohol and the non-volatile solvent may comprise a polyhydric alcohol and optionally a glycol. A low-concentration vasodilator-containing composition is also described. The compositions allow a “virtual injection” of the active ingredient to be delivered transdermally without general systemic uptake.Type: GrantFiled: January 23, 2007Date of Patent: February 23, 2016Assignee: FUTURA MEDICAL DEVELOPMENTS LIMITEDInventor: Adrian Francis Davis
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Patent number: 8951553Abstract: A composition for topical application to a part of the body comprises a vasodilator, for example glyceryl trinitrate, as active ingredient dissolved in a blend of volatile and non-volatile solvents of different solvating capacities for the vasodilator. The vasoldator is present in the composition at a concentration at or slightly below saturation, whereby evaporation of the volatile solvent in use will maintain the vasodilator at saturated or super-saturated concentrations in the residue, whereby the vasodilator will become saturated or supersaturated in the solvent remaining and, as the active ingredient passes through the skin and is absorbed in the bloodstream, and thus becomes depleted in the residual composition, continuing evaporation of volatile solvent will maintain the active ingredient substantially at saturation or supersaturation level in the residual composition throughout the major part of the absorption phase, thereby maximising absorption levels but at a moderate dosage level.Type: GrantFiled: August 8, 2005Date of Patent: February 10, 2015Assignee: Futura Medical Developments Limited Surrey Technology CentreInventor: Adrian Francis Davis
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Patent number: 8541470Abstract: A composition for topical application of an NSAID comprises a solution or suspension of the NSAID in a carrier system comprising a polyhydric alcohol, a glycol ether and an ester of A higher fatty acid, the carrier system being present as a single phase at ambient temperatures. The NSAID may be diclofenac as diclofenac acid. The polyhydric alcohol may be a glycol such as isopropylene glycol and the glycol ether may be a diethylene glycol ether such as diethylene glycol monoethyl ether.Type: GrantFiled: February 15, 2008Date of Patent: September 24, 2013Assignee: Futura Medical Developments LimitedInventor: Adrian Francis Davis
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Publication number: 20120248142Abstract: A pharmaceutical composition comprises an active ingredient dissolved in an essentially non-aqueous carrier system comprising volatile and non-volatile components, in which the volatile component comprises a volatile non-solvent for the active ingredient and a volatile solvation additive for the non-solvent and the non-volatile component comprises a non-volatile non-solvent and optionally a non-volatile solvent for the active ingredient, the volatile and non-volatile non-solvents comprising silicone fluids of respectively different viscosity.Type: ApplicationFiled: November 10, 2010Publication date: October 4, 2012Applicant: FUTURA MEDICAL DEVELOPMENTS LIMITEDInventor: Adrian Francis Davis
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Publication number: 20100099767Abstract: A composition for topical application of an NSAID comprises a solution or suspension of the NSAID in a carrier system comprising a polyhydric alcohol, a glycol ether and an ester of A higher fatty acid, the carrier system being present as a single phase at ambient temperatures. The NSAID may be diclofenac as diclofenac acid. The polyhydric alcohol may be a glycol such as isopropylene glycol and the glycol ether may be a diethylene glycol ether such as diethylene glycol monoethyl ether.Type: ApplicationFiled: February 15, 2008Publication date: April 22, 2010Inventor: Adrian Francis Davis
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Publication number: 20090018214Abstract: A composition for topical application to a part of the body comprises a local anaesthetic and optionally a vasodilator as active ingredient dissolved in a blend of volatile and non-volatile solvents of different solvating capacities for the active ingredient. The vasodilator may comprise glyceryl trinitrate and the local anaesthetic may comprises an anaesthetic of the aminoamide or aminoester type. The volatile solvent may comprise a mixture of water with a C1-C5 alcohol and the non-volatile solvent may comprise a polyhydric alcohol and optionally a glycol. A low-concentration vasodilator-containing composition is also described. The compositions allow a “virtual injection” of the active ingredient to be delivered transdermally without general systemic uptake.Type: ApplicationFiled: January 23, 2007Publication date: January 15, 2009Inventor: Adrian Francis Davis
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Publication number: 20080081058Abstract: A composition for topical application to a part of the body comprises a vasodilator, for example glyceryl trinitrate, as active ingredient dissolved in a blend of volatile and non-volatile solvents of different solvating capacities for the vasodilator. The vasoldator is present in the composition at a concentration at or slightly below saturation, whereby evaporation of the volatile solvent in use will maintain the vasodilator at saturated or super-saturated concentrations in the residue, whereby the vasodilator will become saturated or supersaturated in the solvent remaining and, as the active ingredient passes through the skin and is absorbed in the bloodstream, and thus becomes depleted in the residual composition, continuing evaporation of volatile solvent will maintain the active ingredient substantially at saturation or supersaturation level in the residual composition throughout the major part of the absorption phase, thereby maximising absorption levels but at a moderate dosage level.Type: ApplicationFiled: August 8, 2005Publication date: April 3, 2008Inventor: Adrian Francis Davis
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Patent number: 5823394Abstract: A dispenser for dispensing together a first fluid material and a second fluid material comprising a first material chamber (1a) and a second material supply chamber (1b) for containing first and second fluid materials, and a headpiece (2) comprising a first pump chamber (24) having a first pump piston (27) and being connectable to a first discharge channel (30) and to the first material supply chamber (1a) and a second pump chamber (19) having a second pump piston (26) and being connectable to a second discharge channel (31) and to the second material supply chamber (1b), and having a coaxial arrangement.Type: GrantFiled: November 26, 1996Date of Patent: October 20, 1998Assignee: SmithKline Beecham p.l.c.Inventors: Adrian Francis Davis, Willy Lorscheidt, David Reed Wilkins
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Patent number: 5807569Abstract: Two-component pharmaceutical compositions for topical application to the human or animal body and intended for mixing together on or immediately prior to application, comprising two liquid phases having different lipophilicities and a drug dissolved in at least one of the liquid phases.Type: GrantFiled: May 17, 1995Date of Patent: September 15, 1998Assignee: SmithKline Beecham p.l.c.Inventors: Adrian Francis Davis, Jennifer Jane Gordon
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Patent number: 5673821Abstract: A dispenser is provided for the concurrent dispensing of two different fluid materials. The dispenser has a first and second supply chamber for containing the two separate fluids, and a headpiece having a first pump chamber and pump piston connected to the first supply chamber and a first discharge channel, and a second pump chamber and pump piston connected to the second supply chamber and a second discharge channel. The first and second supply chambers have a coaxial arrangement.Type: GrantFiled: May 9, 1995Date of Patent: October 7, 1997Assignee: SmithKline Beecham PLCInventors: Adrian Francis Davis, Willy Lorscheidt, David Reed Wilkins
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Patent number: 5656652Abstract: Compositions for oral administration for the treatment of gastric disorders comprising histamine H.sub.2 -receptor antagonist, and antacid, optimally buffered to promote local absorption of the H.sub.2 -receptor antagonist, wherein the quantity of H.sub.2 -receptor antagonist per unit dosage form is less than 25 mg.Type: GrantFiled: June 15, 1994Date of Patent: August 12, 1997Assignee: SmithKline Beecham plcInventor: Adrian Francis Davis