Patents by Inventor Adrian Gill

Adrian Gill has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210101870
    Abstract: The present disclosure is directed to inhibitors of SHP2, such as pyrazine compounds, and their use in the treatment of disease associated with SHP2 modulation, such as Noonan Syndrome, Leopard Syndrome, juvenile myelomonocytic leukemias, neuroblastoma, melanoma, acute myeloid leukemia and cancers of the breast, lung and colon. Also disclosed are pharmaceutical compositions comprising the same.
    Type: Application
    Filed: June 18, 2020
    Publication date: April 8, 2021
    Inventors: Elena S. KOLTUN, Kevin MELLEM, Adrian GILL, Gert KISS, Christopher SEMKO, Naing AAY, Andreas BUCKL, Ashutosh JOGALEKAR, Walter WON
  • Patent number: 10590090
    Abstract: The present disclosure is directed to inhibitors of SHP2, such as pyrazine compounds, and their use in the treatment of disease associated with SHP2 modulation, such as Noonan Syndrome, Leopard Syndrome, juvenile myelomonocytic leukemias, neuroblastoma, melanoma, acute myeloid leukemia and cancers of the breast, lung and colon. Also disclosed are pharmaceutical compositions comprising the same.
    Type: Grant
    Filed: December 20, 2018
    Date of Patent: March 17, 2020
    Assignee: REVOLUTION MEDICINES, INC.
    Inventors: Elena S. Koltun, Kevin Mellem, Adrian Gill, Gert Kiss, Christopher Semko, Naing Aay, Andreas Buckl, Ashutosh Jogalekar, Walter Won
  • Publication number: 20200017517
    Abstract: The present disclosure is directed to inhibitors of SHP2 and their use in the treatment of disease. Also disclosed are pharmaceutical compositions comprising the same.
    Type: Application
    Filed: July 22, 2019
    Publication date: January 16, 2020
    Inventors: Adrian GILL, Naing AAY, Kevin MELLEM, Andreas BUCKL, Elena S. KOLTUN, Christopher SEMKO, Gert KISS
  • Publication number: 20200017511
    Abstract: The present disclosure is directed to inhibitors of SHP2 and their use in the treatment of disease. Also disclosed are pharmaceutical compositions comprising the same.
    Type: Application
    Filed: July 22, 2019
    Publication date: January 16, 2020
    Inventors: Brian R. BLANK, Jennifer PITZEN, Gang WANG, Walter S. WON, Christos TZITZILONIS, Jie Jack LI, Elena S. KOLTUN, Naing AAY, Andreas BUCKL, Kevin MELLEM, Christopher SEMKO, Ash JOGALEKAR, Gert KISS, Adrian GILL
  • Publication number: 20190210977
    Abstract: The present disclosure is directed to inhibitors of SHP2 and their use in the treatment of disease. Also disclosed are pharmaceutical compositions comprising the same.
    Type: Application
    Filed: December 20, 2018
    Publication date: July 11, 2019
    Inventors: Ashutosh JOGALEKAR, Walter WON, Elena S. KOLTUN, Adrian GILL, Kevin MELLEM, Naing AAY, Andreas BUCKL, Christopher SEMKO, Gert KISS
  • Patent number: 10302065
    Abstract: A strip of fiber-reinforced polymeric material for a longitudinal reinforcing structure of a wind turbine blade, the strip having substantially flat upper and lower surfaces and extending longitudinally between first and second transverse edges, wherein an end region of the strip tapers in thickness towards the first transverse edge, and wherein one or more slots are defined in the tapered end region, the or each slot extending longitudinally from the first transverse edge of the strip into the tapered end region.
    Type: Grant
    Filed: November 14, 2014
    Date of Patent: May 28, 2019
    Assignee: Vestas Wind Systems A/S
    Inventors: Jonathan Smith, Adrian Gill, Mark Hancock
  • Publication number: 20160273516
    Abstract: A strip of fibre-reinforced polymeric material for a longitudinal reinforcing structure of a wind turbine blade, the strip having substantially flat upper and lower surfaces and extending longitudinally between first and second transverse edges, wherein an end region of the strip tapers in thickness towards the first transverse edge, and wherein one or more slots are defined in the tapered end region, the or each slot extending longitudinally from the first transverse edge of the strip into the tapered end region.
    Type: Application
    Filed: November 14, 2014
    Publication date: September 22, 2016
    Inventors: Jonathan Smith, Adrian Gill, Mark Hancock
  • Patent number: 9032622
    Abstract: An elongate web is attached to the root end of a spar of a wind turbine rotor blade to provide additional support along the width of the blade. The root end is formed by a winding operation, and a recess is then cut into the surface of the spar. The recess is defined by a relatively large first, cylindrical surface, which is coaxial with the longitudinal axis of the root end, and a relatively small second, conical surface. A tapered end of the elongate web is attached within the recess of the root end using a layer of suitable adhesive and an array of pins. Resilient spacer elements are arranged within the recess so as to surround the pins. The large area of the cylindrical surface causes the tensile and compressive stresses which arise along the elongate web in use to be transmitted to the spar as shear stresses.
    Type: Grant
    Filed: December 12, 2011
    Date of Patent: May 19, 2015
    Assignee: Vestas Wind Systems A/S
    Inventors: Mark Hancock, Anton Bech, Rens Christiaan Verhoef, Adrian Gill, Karl Gregory
  • Patent number: 8807954
    Abstract: The invention relates to a method of preparing an assembly, including providing a first structure; providing a second structure; providing at least one flexible adhesive limiting member extending between the structures; and providing an adhesive between the structures to bind the structures to each other; wherein the adhesive is limited by the flexible adhesive limiting member such that a concave front line surface of the adhesive is defined. The invention also relates to such an assembly as well as to a wind turbine rotor blade, and to a wind turbine, having such an assembly.
    Type: Grant
    Filed: August 19, 2009
    Date of Patent: August 19, 2014
    Assignee: Vestas Wind Systems A/S
    Inventor: Adrian Gill
  • Publication number: 20120246931
    Abstract: An elongate web is attached to the root end of a spar of a wind turbine rotor blade to provide additional support along the width of the blade. The root end is formed by a winding operation, and a recess is then cut into the surface of the spar. The recess is defined by a relatively large first, cylindrical surface, which is coaxial with the longitudinal axis of the root end, and a relatively small second, conical surface. A tapered end of the elongate web is attached within the recess of the root end using a layer of suitable adhesive and an array of pins. Resilient spacer elements are arranged within the recess so as to surround the pins. The large area of the cylindrical surface causes the tensile and compressive stresses which arise along the elongate web in use to be transmitted to the spar as shear stresses.
    Type: Application
    Filed: December 12, 2011
    Publication date: October 4, 2012
    Applicant: VESTAS WIND SYSTEMS A/S
    Inventors: Mark Hancock, Anton Bech, Rens Christiaan Verhoef, Adrian Gill, Karl Gregory
  • Publication number: 20110142663
    Abstract: The invention relates to a method of preparing an assembly, comprising providing a first structure; providing a second structure; providing at least one flexible adhesive limiting member extending between said structures; and providing an adhesive between said structures to bind said structures to each other; wherein the adhesive is limited by the flexible adhesive limiting member such that a concave front line surface of the adhesive is defined. The invention also relates to such an assembly as well as to a wind turbine rotor blade, and to a wind turbine, comprising such an assembly.
    Type: Application
    Filed: August 19, 2009
    Publication date: June 16, 2011
    Applicant: VESTAS WIND SYSTEMS A/S
    Inventor: Adrian Gill
  • Publication number: 20080015191
    Abstract: The present invention pertains to certain pyrazines and pyridines, and derivatives thereof, which, inter alia, inhibit RAF (e.g., B RAF) activity, inhibit cell proliferation, treat cancer, etc.
    Type: Application
    Filed: December 22, 2005
    Publication date: January 17, 2008
    Applicant: THE WELLCOME TRUST LIMITED
    Inventors: Caroline Springer, Ion Niculescu-Duvaz, Esteban Vela, Adrian Gill, Richard Taylor, Richard Marais
  • Publication number: 20080004270
    Abstract: The invention provides compounds of the formula (I); or salts or solvates or N-oxides thereof; wherein: Rq is selected from groups (a), (b) and (c); the asterisk denoting the point of attachment to the pyrazole ring; X is N or CR5; X? is NR4; O, S or S(O); A is a bond or —(CH2)m—(B)n—; B is C?O, NRg(C?O) or O(C?O) wherein Rg is hydrogen or C1-4 hydrocarbyl optionally substituted by hydroxy or C1-4 alkoxy; m is 0, 1 or 2; n is 0 or 1; R0 is hydrogen or, together with NRg when present, forms a group —(CH2)p— wherein p is 2 to 4; and R1 to R6b are as defined in the description. Compounds of the formula (I) have activity as inhibitors of CDK, aurora and GSK-3 kinases are useful in treating or preventing diseases such as cancers that are mediated by the said kinases.
    Type: Application
    Filed: July 5, 2005
    Publication date: January 3, 2008
    Applicant: ASTEX THERAPEUTICS LIMITED
    Inventors: Adrian Gill, Maria Carr, Michael O'Brien, Paul Wyatt, Valerio Berdini
  • Publication number: 20070287838
    Abstract: The present invention pertains to certain imidazo[4,5-b]pyridin-2-one and oxazolo[4,5-b]pyridin-2-one compounds and analogs thereof, which, inter alia, inhibit RAF (e.g., B-RAF) activity, inhibit cell proliferation, treat cancer, etc.
    Type: Application
    Filed: October 21, 2005
    Publication date: December 13, 2007
    Applicants: CANCER RESEARCH TECHNOLOGY LIMITED, INSTITUE OF CANCER RESEARCH: ROYAL CANCER HOSPITAL (THE), ASTEX THERAPEUTICS LIMITED
    Inventors: Dan Niculescu-Duvaz, Caroline Springer, Adrian Gill, Richard Taylor, Richard Marais, Hermen Dijkstra, Catherine Gaulon, Delphine Menard, Esteban Roman Vela
  • Publication number: 20070208015
    Abstract: The invention provides compounds of the formula (I) or a salt, solvate or N-oxide thereof, wherein: R1 and R2 are the same or different and each is selected from hydrogen, saturated C1-3 hydrocarbyl, halogen and cyano; X is selected from C?O, C?S, C(?O)NH, C(?S)NH, C(?O)O, C(?O)S, C(?S)O and C(?S)S; R3 is selected from aryl and heteroaryl groups each having from 5 to 12 ring members and being unsubstituted or substituted by one or more substituent groups R10 as defined in the claims; R4 and R5 are the same or different and are selected from hydrogen and methyl; or one of R4 and R5 is selected from hydroxymethyl and ethyl and the other is hydrogen; and R6 and R7 are the same or different and are selected from hydrogen and methyl. The compounds of the formula (I) hayed activity as p38 MAP kinase and Taf kinase inhibitors.
    Type: Application
    Filed: April 13, 2005
    Publication date: September 6, 2007
    Applicant: ASTEX THERAPEUTICS, LTD.
    Inventors: Adrian Gill, Maria Carr, John Lyons, Neil Thompson, David Rees
  • Publication number: 20070135477
    Abstract: The invention provides compounds of the formula (1): The compounds have activity against cyclin depdenent kinases, glycogen synthase kinase and Auroa kinases and are therefore useful to treat cancer and viral diseases.
    Type: Application
    Filed: July 5, 2004
    Publication date: June 14, 2007
    Applicant: ASTEX Therapeuctics, Limited
    Inventors: Valerio Berdini, Michael O'Brien, Maria Carr, Theresa Early, Eva Navarro, Adrian Gill, Steven Howard, Gary Trewartha, Alison Woolford, Andrew Woodhead, Paul Wyatt
  • Publication number: 20070082898
    Abstract: The invention provides the use of a compound for the manufacture of a medicament for the prophylaxis or treatment of a disease state or condition mediated by a p38 MAP kinase; the compound being defined by formula (I): wherein: R1 and R2 are the same or different and each is selected from hydrogen, C1-4 hydrocarbyl, halogen and cyano; X is selected from C?O, C?S, C(?O)NH, C(?S)NH, C(?O)O, C(?O)S, C(?S)O and C(?S)S; R3 is selected from aryl and hetcroaryl groups each having from 5 to 12 ring members, the aryl and heteroaryl groups each being unsubstituted or substituted by one or more substituent groups R7 selected from halogen, hydroxy, trifluoromethyl, cyano, nitro, carboxy, amino, carbocyclic and heterocyclic groups having from 3 to 12 ring members; a group Ra—Rb wherein Ra is a bond, 0, CO, X1C(X2), C(X2)X1, X1C(X2)X1, S, SO, SO2, NRc, SO2NRc or NRcSO2; and Rb is selected from hydrogen, carbocyclic and heterocyclic groups having from 3 to 7 ring members, and a C1-8 hydrocarbyl group optionally substituted
    Type: Application
    Filed: April 13, 2004
    Publication date: April 12, 2007
    Applicant: Astex Therapeutics Limited
    Inventors: Adrian Gill, Steven Woodhead, Maria Carr
  • Publication number: 20060194843
    Abstract: The invention provides compounds of the formula (0) or salts or tautomers or N-oxides or solvates thereof for use in the prophylaxis or treatment of disease states and conditions such as cancers mediated by cyclin-dependent kinase and glycogen synthase kinase-3. In formula (0): X is a group R1-A-NR4— or a 5- or 6-membered carbocyclic or heterocyclic ring; A is a bond, SO2, C?O, NRg(C?O) or O(C?O) wherein Rg is hydrogen or C1-4 hydrocarbyl optionally substituted by hydroxy or C1-4 alkoxy; Y is a bond or an alkylene chain of 1, 2 or 3 carbon atoms in length; R1 is hydrogen; a carbocyclic or heterocyclic group having from 3 to 12 ring members; or a C1-8 hydrocarbyl group optionally substituted by one or more substituents selected from halogen (e.g.
    Type: Application
    Filed: January 20, 2006
    Publication date: August 31, 2006
    Applicant: Astex Therapeutics Limited
    Inventors: Valerio Berdini, Michael O'Brien, Maria Carr, Theresa Early, Adrian Gill, Gary Trewartha, Alison Woolford, Andrew Woodhead, Paul Wyatt
  • Publication number: 20060063782
    Abstract: Compounds of the formula (I), wherein: —X?Y— is selected from —CR<2>=CR<3>— and —CR<2>?N—; R<1> is selected from H, halo, NRR?, NHC(?O)R, NHC(?O)NRR?, NH2SO2R, and C(?O)NRR?; R<2> and R<3> (where present) are independently selected from H, optionally substituted C1-7 alkyl, optionally substituted C5-20 aryl, optionally substituted C3-20 heterocyclyl, halo, amino, amido, hydroxy, ether, thio, thioether, acylamido, ureido and sulfonamino; R<4> is an optionally substituted C5-20 aryl or C5-20 heteroaryl group; and R<5> is selected from R<5?>, halo, NHR<5?>, C(?O)NHR<5?>, OR<5?>, SR<5?>, NHC(?O)R<5?>, NHC(?O)NHR<5?>, NHS(?O)R<5?>, wherein R<5?> is H or C1-3 alkyl (optionally substituted by halo, NH2, OH, SH) are disclosed for use in therapy and for treating diseases ameliorated by inhibiting p38 MAP kinase.
    Type: Application
    Filed: July 3, 2003
    Publication date: March 23, 2006
    Inventors: Christopher Murray, Michael Hartshorn, Martyn Frederickson, Miles Congreve, Alessandro Padova, Steven Woodhead, Adrian Gill, Andrew Woodhead
  • Publication number: 20050124620
    Abstract: Compounds are disclosed of the formula (I): in which U, T, V and W are each a nitrogen atom or carbon atom. When U, T, V or W is a carbon atom, it may be substituted. The compounds are inhibitors of p38 MAP kinase and are useful for treating inflammatory diseases such as arthritis.
    Type: Application
    Filed: October 8, 2004
    Publication date: June 9, 2005
    Inventors: Martyn Frederickson, Adrian Gill, Alessandro Padova, Miles Congreve