Abstract: Provided are systems and methods for determining and displaying service performance information via a graphical user interface. A method can include visually rendering a service-level dashboard reflecting performance of a service and presenting a visual indication of health of each component service and a list of events each corresponding to a change in performance of one of the component services. The method can further include responsive to receiving, via a graphical user interface (GUI), a selection of a component service, visually rendering a system-level dashboard reflecting performance of the selected component-level service, wherein the component service is performed by one or more machines, and wherein the system-level dashboard presents the machines and one or more events each corresponding to a change in performance of one of the machines.

Abstract: Provided are systems and methods for determining and displaying service performance information via a graphical user interface. A method can include visually rendering a service-level dashboard reflecting performance of a service and presenting a visual indication of health of each component service and a list of events each corresponding to a change in performance of one of the component services. The method can further include responsive to receiving, via a graphical user interface (GUI), a selection of a component service, visually rendering a system-level dashboard reflecting performance of the selected component-level service, wherein the component service is performed by one or more machines, and wherein the system-level dashboard presents the machines and one or more events each corresponding to a change in performance of one of the machines.

Abstract: An operating theatre light comprising at least one environmental sensor. The operating theatre light includes a sensor housing attached to the operating theatre light. The sensor housing defines an enclosure containing the at least one environmental sensor. The sensor housing is protected (e.g. sealed) against the ingress of liquid to the enclosure. The operating theatre light may have a transmitter or transceiver or wired connection for transmitting environmental sensor data produced by the at least one environmental sensor. An operating theatre system comprising the operating theatre light and a control panel comprising a receiver or transceiver configured to receive environmental sensor data transmitted by the operating theatre light.

Abstract: The present invention relates to tetrahydroisoquinolinyl derivatives of formula (I), which are Positive Allosteric Modulators of D1 and accordingly of benefit as pharmaceutical agents for the treatment of diseases in which D1 receptors play a role.

Abstract: A method for supporting and/or making clinical decisions, especially with relation to cannabis use, that uses computer analytics to automatically analyze data to determine which data is relevant to account for changes in a patient over time, continually improves on that analytical process, and offers predictions, insights, and/or suggestions to support clinical decision making.

Abstract: The present invention relates to octahydroisoquinolinyl derivatives according to formula (I), which are Positive Allosteric Modulators of D1 and accordingly of benefit as pharmaceutical agents for the treatment of diseases in which D1 receptors play a role.

Abstract: Provided herein are compounds and compositions that inhibit telomerase and/or the TERT gene with a mutant promoter. Further provided are small molecule compounds or compositions having beneficial effects in cancer treatment. Methods of making the compounds and compositions and methods of using the compounds and compositions, such as using the compounds and compositions to treat cancer, are also provided.

Abstract: An automatic system for making clinical decisions, especially with relation to cannabis use, that incorporates data from multiple personal tracking devices such as fitness trackers, analyzes that data using machine learning techniques to determine which data points are relevant to account for changes over time, and offers predictions, insights, and/or suggestions to support clinical decision making.

Abstract: Provided are systems and methods for determining and displaying service performance information via a graphical user interface. In one embodiment, a system can provide, for each of one or more machines associated with a service: obtaining performance data for the machine; and comparing the performance data for the machine to one or more predefined performance thresholds for the machine to determine a health status for the machine; and determining a health status for the service based at least in part on the health status of at least one of the one or more machines associated with the service.

Abstract: The present invention relates to certain bis-heteroaryl compounds, pharmaceutical compositions containing them, and methods of using them, including methods for preventing, reversing, slowing, or inhibiting protein aggregation, and methods of treating diseases that are associated with protein aggregation, including neurodegenerative diseases such as Parkinson's disease, Alzheimer's disease, Lewy body disease, Parkinson's disease with dementia, fronto-temporal dementia, Huntington's Disease, amyotrophic lateral sclerosis, and multiple system atrophy, and cancer including melanoma.

Abstract: A system for making clinical decisions.

Abstract: A system for making clinical decisions.

Abstract: A system for making clinical decisions.

Abstract: A system for making clinical decisions.

Abstract: A system for making clinical decisions.

Abstract: The present invention relates to certain bis-heteroaryl compounds, pharmaceutical compositions containing them, and methods of using them, including methods for preventing, reversing, slowing, or inhibiting protein aggregation, and methods of treating diseases that are associated with protein aggregation, including neurodegenerative diseases such as Parkinson's disease, Alzheimer's disease, Lewy body disease, Parkinson's disease with dementia, fronto-temporal dementia, Huntington's Disease, amyotrophic lateral sclerosis, and multiple system atrophy, and cancer including melanoma.

Abstract: The present invention relates to bis-heteroaryl compounds of formula (I), pharmaceutical compositions containing them, and methods of using them, including methods for preventing, reversing, slowing, or inhibiting protein aggregation, and methods of treating diseases that are associated with protein aggregation, including neurodegenerative diseases such as Parkinson's disease, Alzheimer's disease, Lewy body disease, Parkinson's disease with dementia, fronto-temporal dementia, Huntington's Disease, amyotrophic lateral sclerosis, and multiple system atrophy, and cancer including melanoma.

Abstract: The present invention relates to certain bicyclic bis-heteroaryl compounds of Formula (I), pharmaceutical compositions containing them, and methods of using them, including methods for preventing, reversing, slowing, or inhibiting protein aggregation, and methods of treating diseases that are associated with protein aggregation, including neurodegenerative diseases such as Parkinson's disease, Alzheimer's disease, Lewy body disease, Parkinson's disease with dementia, fronto-temporal dementia, Huntington's Disease, amyotrophic lateral sclerosis, and multiple system atrophy, and cancer including melanoma.

Abstract: A wellness system for a user operating on a computing device including a processor for administrating product including at least one of cannabis and cannabinoid includes a monitoring inference engine that receives, at least one of, (i)sensor data from the user; (ii) user input data from the user; (iii) at least one of regimen data and prescription data for at least one of cannabis and cannabinoids; (iv) over the counter medicine data for the user; (v) prescription data for the user. The monitoring inference engine processes such received data using a machine learning based processing engine to provide personalized data for the user.

Abstract: The present invention relates to certain bis-heteroaryl compounds, pharmaceutical compositions containing them, and methods of using them, including methods for preventing, reversing, slowing, or inhibiting protein aggregation, and methods of treating diseases that are associated with protein aggregation, including neurodegenerative diseases such as Parkinson's disease, Alzheimer's disease, Lewy body disease, Parkinson's disease with dementia, fronto-temporal dementia, Huntington's Disease, amyotrophic lateral sclerosis, and multiple system atrophy, and cancer including melanoma.