Patents by Inventor Adrian Marc Simon Jacobs

Adrian Marc Simon Jacobs has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11061015
    Abstract: A method of determining the result of an assay in a microfluidic device includes the steps of: dispensing a sample droplet onto a first portion of an electrode array of the microfluidic device; dispensing a reagent droplet onto a second portion of the electrode array of the microfluidic device; controlling actuation voltages applied to the electrode array to mix the sample droplet and the reagent droplet into a product droplet; sensing a dynamic property of the product droplet; and determining an assay of the sample droplet based on the sensed dynamic property. The dynamic property is a physical property of the product droplet that influences a transport property of the product droplet on the electrode array. Example dynamic properties of the product droplet include the moveable state, split-able state, and viscosity based on droplet properties. The method may be used to perform an amoebocyte lysate (LAL) assay.
    Type: Grant
    Filed: August 28, 2015
    Date of Patent: July 13, 2021
    Assignee: Sharp Life Science (EU) Limited
    Inventors: Benjamin James Hadwen, Adrian Marc Simon Jacobs, Jason Roderick Hector, Michael James Brownlow, Masahiro Adachi, Alison Mary Skinner, Mark Childs
  • Publication number: 20210148890
    Abstract: A method of determining the result of an assay in a microfluidic device includes the steps of: dispensing a sample droplet onto a first portion of an electrode array of the microfluidic device; dispensing a reagent droplet onto a second portion of the electrode array of the microfluidic device; controlling actuation voltages applied to the electrode array to mix the sample droplet and the reagent droplet into a product droplet; sensing a dynamic property of the product droplet; and determining an assay of the sample droplet based on the sensed dynamic property. The dynamic property is a physical property of the product droplet that influences a transport property of the product droplet on the electrode array. Example dynamic properties of the product droplet include the moveable state, split-able state, and viscosity based on droplet properties. The method may be used to perform an amoebocyte lysate (LAL) assay.
    Type: Application
    Filed: January 6, 2021
    Publication date: May 20, 2021
    Inventors: Benjamin James Hadwen, Adrian Marc Simon Jacobs, Jason Roderick Hector, Michael James Brownlow, Masahiro Adachi, Alison Mary Skinner, Mark Childs
  • Patent number: 9841402
    Abstract: An EWOD (or AM-EWOD) device includes a reference electrode and a plurality of array elements, each array element including an array element electrode, and control electronics. In a first mode optimized for EWOD actuation, the control electronics is configured to control a supply of time varying voltages to the array element electrodes and the reference electrode, thereby generating an actuation voltage as a potential difference between voltages at the array element electrodes and the reference electrode. The reference electrode includes a first electrical connection and a second electrical connection. In a second mode, the control electronics further is configured to supply an electrical current flow between the first electrical connection and the second electrical connection to generate resistance heat for controlling temperature of the EWOD device. Control may include sensing a temperature of the EWOD device, and switching between operating in the first or second mode based on the sensed temperature.
    Type: Grant
    Filed: April 15, 2015
    Date of Patent: December 12, 2017
    Assignee: Sharp Life Science (EU) Limited
    Inventors: Robert Julian Amos, Benjamin James Hadwen, Adrian Marc Simon Jacobs, Emma Jayne Walton, Christopher James Brown, Jonathan Buse
  • Publication number: 20170059523
    Abstract: A method of determining the result of an assay in a microfluidic device includes the steps of: dispensing a sample droplet onto a first portion of an electrode array of the microfluidic device; dispensing a reagent droplet onto a second portion of the electrode array of the microfluidic device; controlling actuation voltages applied to the electrode array to mix the sample droplet and the reagent droplet into a product droplet; sensing a dynamic property of the product droplet; and determining an assay of the sample droplet based on the sensed dynamic property. The dynamic property is a physical property of the product droplet that influences a transport property of the product droplet on the electrode array. Example dynamic properties of the product droplet include the moveable state, split-able state, and viscosity based on droplet properties. The method may be used to perform an amoebocyte lysate (LAL) assay.
    Type: Application
    Filed: August 28, 2015
    Publication date: March 2, 2017
    Inventors: Benjamin James Hadwen, Adrian Marc Simon Jacobs, Jason Roderick Hector, Michael James Brownlow, Masahiro Adachi, Alison Mary Skinner, Mark Childs
  • Publication number: 20170056887
    Abstract: A method of determining the result of an assay in a microfluidic device includes the steps of: dispensing a sample droplet onto a first portion of an electrode array of the microfluidic device; dispensing a reagent droplet onto a second portion of the electrode array of the microfluidic device; controlling actuation voltages applied to the electrode array to mix the sample droplet and the reagent droplet into a product droplet; sensing a dynamic property of the product droplet; and determining an assay of the sample droplet based on the sensed dynamic property. The dynamic property is a physical property of the product droplet that influences a transport property of the product droplet on the electrode array. Example dynamic properties of the product droplet include the moveable state, split-able state, and viscosity based on droplet properties. The method may be used to perform an amoebocyte lysate (LAL) assay.
    Type: Application
    Filed: August 28, 2015
    Publication date: March 2, 2017
    Inventors: Benjamin James Hadwen, Adrian Marc Simon Jacobs, Jason Roderick Hector, Michael James Brownlow, Masahiro Adachi, Alison Mary Skinner, Mark Childs
  • Patent number: 9492824
    Abstract: A method of droplet manipulation utilizing a droplet manipulation device includes activating elements of the device to bring a first droplet into proximity of a second droplet, controlling the elements of the device to alter the shape of at least one of the first and second droplets, and further controlling the elements of the device to move at least one of the first or second droplets until the droplets are in contact about an aggregate area. The elements are controlled in a manner so as to control the area of contact and the degree of mixing of the fluid between the first and second droplets. The method may be employed to move particles of a particulate suspension from the first droplet to the second droplet. The droplet manipulation device may be an electrowetting on dielectric (EWOD) device, which includes shaping electrodes activated to shape droplets, and a bridging electrode activated to join the droplets to transfer fluid between the shaped droplets.
    Type: Grant
    Filed: January 16, 2013
    Date of Patent: November 15, 2016
    Assignee: Sharp Kabushiki Kaisha
    Inventors: Adrian Marc Simon Jacobs, Jason Roderick Hector, Hywel Morgan
  • Publication number: 20160305906
    Abstract: An EWOD (or AM-EWOD) device includes a reference electrode and a plurality of array elements, each array element including an array element electrode, and control electronics. In a first mode optimized for EWOD actuation, the control electronics is configured to control a supply of time varying voltages to the array element electrodes and the reference electrode, thereby generating an actuation voltage as a potential difference between voltages at the array element electrodes and the reference electrode. The reference electrode includes a first electrical connection and a second electrical connection. In a second mode, the control electronics further is configured to supply an electrical current flow between the first electrical connection and the second electrical connection to generate resistance heat for controlling temperature of the EWOD device. Control may include sensing a temperature of the EWOD device, and switching between operating in the first or second mode based on the sensed temperature.
    Type: Application
    Filed: April 15, 2015
    Publication date: October 20, 2016
    Inventors: Robert Julian Amos, Benjamin James Hadwen, Adrian Marc Simon Jacobs, Emma Jayne Walton, Christopher James Brown, Jonathan Buse
  • Patent number: 8828336
    Abstract: An active matrix device is provided which includes N array elements arranged spatially in a sequence of first through Nth array elements (where N is an integer ?2); the N array elements each including a write input for receiving a corresponding write input signal which controls operation of the array element, and a sense circuit for sensing a property of the array element and providing a sensor output based on the sensed property; and further including a manipulation circuit including logic circuitry connecting the sensor output from an nth array element in the sequence directly to the write input of an (n+1)th array element and configured to provide the write input signal to the write input of the (n+1)th array element based on the sensor output from the nth array element.
    Type: Grant
    Filed: February 2, 2011
    Date of Patent: September 9, 2014
    Assignee: Sharp Kabushiki Kaisha
    Inventors: Benjamin James Hadwen, Adrian Marc Simon Jacobs, Jason Roderick Hector
  • Publication number: 20140197028
    Abstract: A method of droplet manipulation utilizing a droplet manipulation device includes activating elements of the device to bring a first droplet into proximity of a second droplet, controlling the elements of the device to alter the shape of at least one of the first and second droplets, and further controlling the elements of the device to move at least one of the first or second droplets until the droplets are in contact about an aggregate area. The elements are controlled in a manner so as to control the area of contact and the degree of mixing of the fluid between the first and second droplets. The method may be employed to move particles of a particulate suspension from the first droplet to the second droplet.
    Type: Application
    Filed: January 16, 2013
    Publication date: July 17, 2014
    Applicant: SHARP KABUSHIKI KAISHA
    Inventors: Adrian Marc Simon Jacobs, Jason Roderick Hector, Hywel Morgan
  • Patent number: 8653832
    Abstract: An array element circuit with an integrated impedance sensor is provided. The array element circuit includes an array element which is controlled by application of a drive voltage by a drive element; writing circuitry for writing the drive voltage to the drive element; and sense circuitry for sensing an impedance presented at the drive element.
    Type: Grant
    Filed: July 6, 2010
    Date of Patent: February 18, 2014
    Assignee: Sharp Kabushiki Kaisha
    Inventors: Benjamin J. Hadwen, Jason R. Hector, Adrian Marc Simon Jacobs, Patrick Zebedee
  • Patent number: 8547111
    Abstract: An active-matrix device is provided which includes a plurality of array element circuits arranged in rows and columns; a plurality of source addressing lines each shared between the array element circuits in corresponding same columns; a plurality of gate addressing lines each shared between the array element circuits in corresponding same rows; a plurality of sensor row select lines each shared between the array element circuits in corresponding same rows, wherein each of the plurality of array element circuits includes: an array element which is controlled by application of a drive voltage by a drive element; writing circuitry for writing the drive voltage to the drive element, the writing circuitry being coupled to a corresponding source addressing line and gate addressing line among the plurality of source addressing lines and gate addressing lines; and sense circuitry for sensing an impedance presented at the drive element, the sense circuitry being coupled to a corresponding sensor row select line; and
    Type: Grant
    Filed: July 5, 2011
    Date of Patent: October 1, 2013
    Assignee: Sharp Kabushiki Kaisha
    Inventors: Benjamin J. Hadwen, Jason R. Hector, Adrian Marc Simon Jacobs, Patrick Zebedee
  • Publication number: 20130161193
    Abstract: A microfluidic system includes a microfluidic device; and a metered fluid loading system formed integrally with the microfluidic device and configured to load a discrete metered volume of fluid into the microfluidic device upon actuation.
    Type: Application
    Filed: December 21, 2011
    Publication date: June 27, 2013
    Applicant: SHARP KABUSHIKI KAISHA
    Inventors: Adrian Marc Simon JACOBS, Campbell Donald BROWN, Benjamin James HADWEN, Jason Roderick HECTOR
  • Patent number: 8419273
    Abstract: An array element for a temperature sensor array circuit. The array element includes a switch transistor; and a temperature sensor element having an impedance which varies as a function of temperature, the temperature sensor element being connected in parallel with a source and drain of the switch transistor.
    Type: Grant
    Filed: May 3, 2010
    Date of Patent: April 16, 2013
    Assignee: Sharp Kabushiki Kaisha
    Inventors: Benjamin James Hadwen, Jason Roderick Hector, Adrian Marc Simon Jacobs, Michael Paul Coulson
  • Patent number: 8289458
    Abstract: A display is switchable between a first display mode with a first viewing angle range, a second display mode having a second viewing angle range smaller than the first viewing angle range and a multiple view directional display mode. The display includes an image display layer and a control element that is switchable between a first state in which it cooperates with the image display layer to provide the first display mode, a second state in which it cooperates with the image display layer to provide the second display mode, and a third state in which it cooperates with the image display layer to provide the multiple view directional display mode.
    Type: Grant
    Filed: May 19, 2006
    Date of Patent: October 16, 2012
    Assignee: Sharp Kabushiki Kaisha
    Inventors: Emma Jayne Walton, Adrian Marc Simon Jacobs, Heather Ann Stevenson, Paul A. Gass
  • Publication number: 20120194492
    Abstract: An active matrix device is provided which includes N array elements arranged spatially in a sequence of first through Nth array elements (where N is an integer ?2); the N array elements each including a write input for receiving a corresponding write input signal which controls operation of the array element, and a sense circuit for sensing a property of the array element and providing a sensor output based on the sensed property; and further including a manipulation circuit including logic circuitry connecting the sensor output from an nth array element in the sequence directly to the write input of an (n+1)th array element and configured to provide the write input signal to the write input of the (n+1)th array element based on the sensor output from the nth array element.
    Type: Application
    Filed: February 2, 2011
    Publication date: August 2, 2012
    Inventors: Benjamin James HADWEN, Adrian Marc Simon Jacobs, Jason Roderick Hector
  • Patent number: 8173000
    Abstract: An active matrix electrowetting on dielectric (AM-EWOD) device which includes a plurality of array elements configured to manipulate one or more droplets of fluid on an array, each of the array elements including a corresponding array element circuit. Each array element circuit includes a top substrate electrode and a drive electrode between which the one or more droplets may be positioned; circuitry configured to write data to the corresponding array element by selectively applying to the drive electrode either: (i) a time-varying voltage waveform V1 of amplitude VB and period t0; or (ii) a time-varying voltage waveform V2, the logical inverse of V1, and applying to the top substrate electrode the time-varying voltage waveform V2+Voffset, where Voffset represents an offset voltage signal which may have AC and/or DC components and may equal zero.
    Type: Grant
    Filed: January 18, 2011
    Date of Patent: May 8, 2012
    Assignee: Sharp Kabushiki Kaisha
    Inventors: Benjamin James Hadwen, Adrian Marc Simon Jacobs, Jason Roderick Hector, Gareth John
  • Publication number: 20120007608
    Abstract: An active-matrix device is provided which includes a plurality of array element circuits arranged in rows and columns; a plurality of source addressing lines each shared between the array element circuits in corresponding same columns; a plurality of gate addressing lines each shared between the array element circuits in corresponding same rows; a plurality of sensor row select lines each shared between the array element circuits in corresponding same rows, wherein each of the plurality of array element circuits includes: an array element which is controlled by application of a drive voltage by a drive element; writing circuitry for writing the drive voltage to the drive element, the writing circuitry being coupled to a corresponding source addressing line and gate addressing line among the plurality of source addressing lines and gate addressing lines; and sense circuitry for sensing an impedance presented at the drive element, the sense circuitry being coupled to a corresponding sensor row select line; and
    Type: Application
    Filed: July 5, 2011
    Publication date: January 12, 2012
    Applicant: SHARP KABUSHIKI KAISHA
    Inventors: Benjamin J. HADWEN, Jason R. HECTOR, Adrian Marc Simon JACOBS, Patrick ZEBEDEE
  • Publication number: 20120006684
    Abstract: An array element circuit with an integrated impedance sensor is provided. The array element circuit includes an array element which is controlled by application of a drive voltage by a drive element; writing circuitry for writing the drive voltage to the drive element; and sense circuitry for sensing an impedance presented at the drive element.
    Type: Application
    Filed: July 6, 2010
    Publication date: January 12, 2012
    Inventors: Benjamin J. HADWEN, Jason R. Hector, Adrian Marc Simon Jacobs, Patrick Zebedee
  • Publication number: 20110268151
    Abstract: An array element for a temperature sensor array circuit.
    Type: Application
    Filed: May 3, 2010
    Publication date: November 3, 2011
    Inventors: Benjamin James Hadwen, Jason Roderick Hector, Adrian Marc Simon Jacobs, Michael Paul Coulson
  • Publication number: 20100117988
    Abstract: A touch sensor for a touch display is provided which includes an optical element including at least one electrically conductive layer, the at least one electrically conductive layer being partially reflective and partially transmissive with respect to incident light; and sensing circuitry electrically coupled to the at least one electrically conductive layer to determine positioning of a finger, hand or other type of pointing device relative to the optical element.
    Type: Application
    Filed: November 12, 2008
    Publication date: May 13, 2010
    Inventors: Adrian Marc Simon JACOBS, Harry Garth Walton