Abstract: The invention relates to urea and amido compounds of the formula ##STR1## which have a powerful action on tumors, and to processes for their preparation and pharmaceutical preparations containing such compounds.

Abstract: The invention relates to urea and amido compounds of the formula ##STR1## which have a powerful action on tumors, and to processes for their preparation and pharmaceutical preparations containing such compounds.

Abstract: Compounds of the general formula ##STR1## wherein R.sub.1 represents a hydrogen atom or a lower alkyl group, which contain a double bond in 5-position and a methyl group in 10-position, or three double bonds in the position 1,3 and 5)10), and which can contain an additional double bond in the 9(11)-position, are manufactured by a novel process, in which a 17-oxosteroid of the general formula ##STR2## wherein R.sub.1 ' represents a hydrogen atom, a lower alkyl group or an acyl group, and which contains double bonds and optionally a methyl group in the positions indicated above, is reacted with an organometallic compound of the formulaR.sub.o --(CH.sub.2).sub.3 --M (III)wherein M represents a grouping MgX, in which X represents a halogen atom or an alkali metal atom and R.sub.o represents a di-lower alkylamino group, and the resultant 17.beta.-hydroxy-17.alpha.-(.gamma.-di-lower alkylaminopropyl) compound of the general formula ##STR3## WHEREIN R.sub.1 and R.sub.

Abstract: A process is disclosed for the purification of crude dehydroacetic acid by means of simple vacuum or reduced pressure distillation wherein activated charcoal is added to the still. The term reduced pressure is used in the sense that it excludes complicated distillations such as fractional distillation and it is synonymous with simple vacuum distillation. Preferably a pressure of about 10 to about 20 torr is maintained in the vacuum distillation still. Preferably, 0.1 to 1 percent by weight, relative to the total amount of the crude dehydroacetic acid, of activated charcoal is added to the still before the distillation occurs. Crude dehydroacetic acid, particularly that obtained from diketene, is quite impure and discolored. The process of this invention produces a pure dehydroacetic acid, which is pure white, has a transparency of 96 percent and which has a purity of greater than 99.9 percent.