Abstract: A humidification system can include a heater base, a humidification chamber, and a breathing circuit. A cartridge can be removably coupled to the heater base. The cartridge can include various sensors, probes, sensor wire connectors, heater wire connectors, and/or other features. The cartridge can include features configured to mate with corresponding features on the humidification chamber and the heater base. The cartridge includes a memory, such as an EEPROM, or other suitable storage device. When the cartridge is installed on the heater base, the memory is electrically connected to a processor and/or memory of the heater base. Various models of cartridges can be produced for use with different humidification chambers, breathing circuits, and/or therapies. A connector can be configured to couple an inspiratory conduit to an outlet port of the humidification chamber. The connector can provide a pneumatic connection to the outlet port and an electrical connection to the cartridge.

Abstract: A circuit connector for a humidification system, the system comprising a base unit configured to be engaged by a humidification chamber. The circuit connector comprises an inlet to fluidly connect to an outlet of the humidification chamber to receive humidified gases therefrom, an outlet to sealably connect to or integral with a conduit for directing the humidified gases to a user, and an electrical terminal for electrically coupling the circuit connector to an electrical terminal associated with the base unit. The circuit connector may be releasably and lockably connectable to the outlet of the humidification chamber and/or orientation features may control orientation of component parts of the system as they are assembled.

Abstract: The invention relates to methods and kits for determining a SARS-CoV-2 strain in a sample. The invention further provides methods and kits for detecting a single nucleotide polymorphism (SNP) in a target nucleic acid, wherein the target nucleic acid is a SARS-CoV-2 nucleic acid. The invention further provides methods and kits for detecting one or more antibody biomarkers in a sample.

Abstract: The invention relates to methods and kits for detecting a virus, e.g., a respiratory virus such as a coronavirus, in a biological sample. The invention also relates to methods and kits for detecting and/or quantifying biomarkers, e.g., antibody biomarkers against a viral antigen; inflammatory and/or tissue damage response biomarkers; and/or extracellular vesicles in response to a viral infection.

Abstract: Enteral connectors having coupling features for providing removable or permanent coupling engagement with a syringe connector. In some example embodiments, the syringe connector includes an ENFit compatible female connector. In other example embodiments, the syringe connector includes a threaded tip.

Abstract: An improved oral administration coupler for delivery of fluids such as medications and nutritional fluids. Example oral administration couplers have a first end with an applicator for oral delivery to an infant, and a second end with a coupling compatible with an enteral fluid delivery syringe. A fluid delivery conduit extends in fluid communication from the first end to the second end, to deliver fluid from the syringe to the infant. In some example embodiments, the coupler is configured for back-of-mouth delivery, and can comprise a generally elongate and at least partially flexible tube or straw.

Abstract: An improved oral administration coupler for delivery of fluids such as medications and nutritional fluids. Example oral administration couplers have a first end with an applicator for oral delivery to an infant, and a second end with a coupling compatible with an enteral fluid delivery syringe. A fluid delivery conduit extends in fluid communication from the first end to the second end, to deliver fluid from the syringe to the infant. In some example embodiments, the coupler is configured for back-of-mouth delivery, and can comprise a generally elongate and at least partially flexible tube or straw.

Abstract: An adjustable knee brace for fitting a variety of leg sizes and adjustable to limit flexion or extension motion of a knee. The knee brace includes an adjustable length provided by a strut that telescopes within a receiver. A latch assembly mounted on the receiver selectively applies a frictional force to lock the strut member and the receiver against relative telescoping movement. An adjustable range of motion hinge is operatively associated with the telescoping strut. The hinge includes a hinge plate connected to the strut member and having a semi-circular peripheral edge defining a plurality of uniformly spaced apart keys. A range of motion stop is movably positionable relative to the semi-circular peripheral edge and includes a movable latch having teeth.

Abstract: An improved oral administration coupler for delivery of fluids such as medications and nutritional fluids. Example oral administration couplers have a first end with an applicator for oral delivery to an infant, and a second end with a coupling compatible with an enteral fluid delivery syringe. A fluid delivery conduit extends in fluid communication from the first end to the second end, to deliver fluid from the syringe to the infant. In some example embodiments, the coupler is configured for back-of-mouth delivery, and can comprise a generally elongate and at least partially flexible tube or straw.

Abstract: An improved oral administration coupler for delivery of fluids such as medications and nutritional fluids. Example oral administration couplers have a first end with an applicator for oral delivery to an infant, and a second end with a coupling compatible with an enteral fluid delivery syringe. A fluid delivery conduit extends in fluid communication from the first end to the second end, to deliver fluid from the syringe to the infant. In some example embodiments, the coupler is configured for back-of-mouth delivery, and can comprise a generally elongate and at least partially flexible tube or straw.

Abstract: Enteral connectors having coupling features for providing removable or permanent coupling engagement with a syringe connector. In some example embodiments, the syringe connector includes an ENFit compatible female connector. In other example embodiments, the syringe connector includes a threaded tip.

Abstract: A system and method for collection of colostrum or other enteral fluid using a breast pump or other collection device directly into a syringe for storage and dispensing of the colostrum for feeding a newborn infant. A collar adaptor couples the syringe body or barrel in sealing engagement with the discharge coupling of the breast pump to transfer expressed colostrum directly from the breast pump to the collection syringe.

Abstract: A method, computer program product, and apparatus comprise providing a Java developer kit class library comprising first Java classes; providing a Java Open Foundation class library comprising second Java classes each containing one or more of the first Java classes; providing a .NET SDK class library comprising .NET classes; providing a .NET language Open Foundation class library comprising first .NET language classes each containing one or more of the NET classes; wherein each of the .NET language classes presents the same method signature as one of the second Java classes; receiving Java source code defining third Java classes, first calls to the first Java classes, and second calls to the second Java classes; translating the third Java classes into second .NET language classes; and translating the first calls to calls into the .NET SDK class library without modifying the second calls.

Abstract: The present invention provides methods of detecting specific lysis of a cell by a lytic agent. The methods generally involve contacting a labeled target cell with a lytic agent; and detecting fluorescence in the target cell. The target cells are labeled with two fluorescent labels: a first fluorescent label that labels the plasma membrane; and a second fluorescent label that labels the cytosol. Release of the cytosolic label from the target cell indicates that the target cell has been lysed. The invention further provides methods of detecting the presence in a sample of a cell that specifically lyses a target cell. The invention further provides methods of detecting the presence in a sample of an antibody that specifically lyses a target cell. The methods are useful in a variety of applications.