Abstract: Disclosed herein are pyrazole pyrimidine compounds that modulate and/or inhibit hematopoietic progenitor kinase 1, as well as methods of making such compounds and therapeutic methods of using same.

Abstract: Hyperstable liposome comprising an anti-mitotic agent, one or more anions and one or more cations entrapped in the inner milieu, wherein the entrapped anti-mitotic drug is released at a slow rate that is less than 0.6% in 12 hours or less than 5% in 8 hours when the liposomes are suspended in 600 mM sucrose. These liposomes are useful in the treatment of cancer. In particular, HEPC:Chol:DSPE-PEG2000 (50:45:5) liposomes comprising BI 2536 and citrate:phosphate in a ratio of 1:3.

Abstract: The present disclosure relates to a detection system, and, more particularly, to system for detection of passive voltage contrast and methods of use. The system includes a chamber; a stage provided within the chamber, configured to stage a target structure; an electron beam apparatus which is structured to emit an e-beam toward the stage; and a laser source which emits a laser signal toward the stage, at a same area as the e-beam.

Abstract: The present disclosure relates to a detection system, and, more particularly, to system for detection of passive voltage contrast and methods of use. The system includes a chamber; a stage provided within the chamber, configured to stage a target structure; an electron beam apparatus which is structured to emit an e-beam toward the stage; and a laser source which emits a laser signal toward the stage, at a same area as the e-beam.

Abstract: A 3D glasses device incorporating real time tracking and a system for implementing the 3D glasses device for an immersive virtual reality experience includes 3D glasses that comprise: a frame, a pair of lens, and a real-time tracking unit, which enables the position and orientation to be observed by optical tracking systems featuring optical transmitters. In one exemplary implementation the 3D glasses device communicates with a client system during a session of digital media content rendering. The real-time tracking unit of the 3D glasses device has optical sensors activated when struck by light from an optical transmitter, communicates its position and orientation to the client system, which renders media content based in part on the tracking data, and shows the content on head-mounted display systems that are part of the device in order to produce an immersive virtual reality experience.

Abstract: Techniques for optimizing a query with an extrema function are provided. In main memory, a data summary is maintained for a plurality of extents stored by at least one storage server. The data summary includes an extent minimum value and an extent maximum value for one or more columns. A storage server request is received, from a database server, based on a query with an extrema function applied to a particular column of a particular table. The data summaries for a set of relevant extents are processed by maintaining at least one global extrema value corresponding to the extrema function and, for each relevant extent of the set of relevant extents, determining whether to scan records of the relevant extent based on at least one of the global extrema value and an extent summary value of the data summary of the relevant extent.

Abstract: Hyperstable liposome comprising an anti-mitotic agent, one or more anions and one or more cations entrapped in the inner milieu, wherein the entrapped anti-mitotic drug is released at a slow rate that is less than 0.6% in 12 hours or less than 5% in 8 hours when the liposomes are suspended in 600 mM sucrose. These liposomes are useful in the treatment of cancer. In particular, HEPC:Chol:DSPE-PEG2000 (50:45:5) liposomes comprising BI 2536 and citrate:phosphate in a ratio of 1:3.

Abstract: A 3D glasses device incorporating real time tracking and a system for implementing the 3D glasses device for an immersive virtual reality experience includes 3D glasses that comprise: a frame, a pair of lens, and a real-time tracking unit, which enables the position and orientation to be observed by optical tracking systems featuring optical transmitters. In one exemplary implementation the 3D glasses device communicates with a client system during a session of digital media content rendering. The real-time tracking unit of the 3D glasses device has optical sensors activated when struck by light from an optical transmitter, communicates its position and orientation to the client system, which renders media content based in part on the tracking data, and shows the content on head-mounted display systems that are part of the device in order to produce an immersive virtual reality experience.

Abstract: A method for accelerating queries using dynamically generated columnar data in a flash cache is provided. In an embodiment, a method comprises a storage device receiving a first request for data that is stored in the storage device in a base major format in one or more primary storage devices. The storage device comprises a cache. The base major format is any one of: a row-major format, a column-major format and a hybrid-columnar format. Based on first one or more criteria, it is determined whether to rewrite the data into rewritten data in a rewritten major format. In response to determining to rewrite the data into rewritten data in a rewritten major format, the storage device rewrites at least a portion of the data into particular rewritten data in the rewritten major format. The rewritten data is stored in the cache.

Abstract: A toothbrush system includes a handle with a chamber, a motor coupled to a plunger, a power supply, and a control switch; and a toothbrush head with a bristle unit, and an opening between the chamber rand the bristle unit.

Abstract: Techniques are described herein for supporting multiple versions of a database server within a database machine comprising a separate database layer and storage layer. In an embodiment, the database layer includes compute nodes each hosting one or more instances of a database server. The storage layer includes storage nodes each hosting one or more instances of a storage server, also referred to herein as a “cell server.” In general, the database servers may receive data requests, such as SQL queries, from client applications and service the requests in coordination with the cell servers of the storage layer.

Abstract: Techniques are described herein for supporting multiple versions of a database server within a database machine comprising a separate database layer and storage layer. In an embodiment, the database layer includes compute nodes each hosting one or more instances of a database server. The storage layer includes storage nodes each hosting one or more instances of a storage server, also referred to herein as a “cell server.” In general, the database servers may receive data requests, such as SQL queries, from client applications and service the requests in coordination with the cell servers of the storage layer.

Abstract: Techniques are provided for using an intermediate cache between the shared cache of an application and the non-volatile storage of a storage system. The application may be any type of application that uses a storage system to persistently store data. The intermediate cache may be local to the machine upon which the application is executing, or may be implemented within the storage system. In one embodiment where the application is a database server, the database system includes both a DB server-side intermediate cache, and a storage-side intermediate cache. The caching policies used to populate the intermediate cache are intelligent, taking into account factors that may include which object an item belongs to, the item type of the item, a characteristic of the item, or the type of operation in which the item is involved.

Abstract: Techniques for optimizing a query with an extrema function are provided. In main memory, a data summary is maintained for a plurality of extents stored by at least one storage server. The data summary includes an extent minimum value and an extent maximum value for one or more columns. A storage server request is received, from a database server, based on a query with an extrema function applied to a particular column of a particular table. The data summaries for a set of relevant extents are processed by maintaining at least one global extrema value corresponding to the extrema function and, for each relevant extent of the set of relevant extents, determining whether to scan records of the relevant extent based on at least one of the global extrema value and an extent summary value of the data summary of the relevant extent.

Abstract: Techniques are described herein for supporting multiple versions of a database server within a database machine comprising a separate database layer and storage layer. In an embodiment, the database layer includes compute nodes each hosting one or more instances of a database server. The storage layer includes storage nodes each hosting one or more instances of a storage server, also referred to herein as a “cell server.” In general, the database servers may receive data requests, such as SQL queries, from client applications and service the requests in coordination with the cell servers of the storage layer.

Abstract: Techniques are provided for using an intermediate cache between the shared cache of an application and the non-volatile storage of a storage system. The application may be any type of application that uses a storage system to persistently store data. The intermediate cache may be local to the machine upon which the application is executing, or may be implemented within the storage system. In one embodiment where the application is a database server, the database system includes both a DB server-side intermediate cache, and a storage-side intermediate cache. The caching policies used to populate the intermediate cache are intelligent, taking into account factors that may include which object an item belongs to, the item type of the item, a characteristic of the item, or the type of operation in which the item is involved.