Patents by Inventor Adrian Ortiz

Adrian Ortiz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • STEREOSELECTIVE PREPARATION OF TRANS HALO CYCLOBUTANE
    Publication number: 20250074855
    Abstract: The present invention relates to stereoselective process for the preparation of a compound having formula (2) and (1) wherein X is defined in the specification.
    Type: Application
    Filed: August 17, 2022
    Publication date: March 6, 2025
    Applicant: AMGEN INC.
    Inventors: Adrian ORTIZ, Athimoolam ARUNACHALAMPILLAI
  • PALLADIUM FREE PROCESSES FOR PREPARATION OF ACRYLATE COMPOUNDS
    Publication number: 20240360079
    Abstract: The present invention relates to precious metal (Pd/Pt/Rh/Ru) free, preferably Pd free, processes for preparing a compound having formula (1) wherein: R1, R2, and X are as defined in the specification, or a salt thereof. Preferably, the compound is an iodo acrylate compound.
    Type: Application
    Filed: August 17, 2022
    Publication date: October 31, 2024
    Applicant: AMGEN INC.
    Inventors: Adrian ORTIZ, Jaika DOERFLER, Karina R. VAIDA
  • Process for Synthesizing Naphthyridine Derivatives and Intermediates Thereof
    Publication number: 20240360147
    Abstract: The disclosure provides processes for preparing Compound A, Compound E, Compound I, salts thereof, and/or stereoisomers thereof, as described herein.
    Type: Application
    Filed: August 30, 2022
    Publication date: October 31, 2024
    Inventors: Athimoolam Arunachalampillai, Richard David Crockett, Robert P. Farrell, Ted Charles Judd, Adrian Ortiz, Joanna Robinson, Carolyn S. Wei, Kumiko Yamamoto, Diana Catherine Fager, Heather Claire Johnson, Neil Fred Langille, Liang Zhang
  • Synthesis of 1,2,5-tri-o-benzoyl-3-dibenzylamino-3-deoxyribose as intermediate for producing 3?-amino-3?-deoxyadenosine and 3?-amino-3?-deoxyguanosine and the protected derivatives thereof
    Patent number: 12060384
    Abstract: The invention generally relates to improved processes for the preparation of intermediates of a cyclic dinucleotide which is useful as a STING agonist.
    Type: Grant
    Filed: February 5, 2020
    Date of Patent: August 13, 2024
    Assignee: Bristol-Myers Squibb Company
    Inventors: Changxia Yuan, Michael Anthony Schmidt, Adrian Ortiz, Amanda J. Rogers, Jason J. Zhu, Zhongmin Xu, Miao Yu, Eric M. Simmons, Shulin Wu
  • PROCESS TOWARD THE MANUFACTURE OF (6R,10S)-10-{4-[5-CHLORO-2-(4-CHLORO-1H-1,2,3-TRIAZOL-1-YL)PHENYL]-6-OXO-1(6H)-PYRIMIDINYL}- 1-(DIFLUOROMETHYL)-6-METHYL-1,4,7,8,9,10-HEXAHYDRO-11,15-(METHENO)PYRAZOLO[4,3-B][1,7]DIAZACYCLOTETRADECIN-5(6H)-ONE
    Publication number: 20230416252
    Abstract: The present application generally relates to several processes for the preparation of (6R,10S)-10-{4-[5-chloro-2-(4-chloro-1H-1,2,3-triazol-1-yl)phenyl]-6-oxo-1(6H)-pyrimidinyl}-1-(difluoromethyl)-6-methyl-1,4,7,8,9,10-hexahydro-11,15-(metheno)pyrazolo[4,3-b][1,7]diazacyclotetradecin-5(6H)-one: Compound (I).
    Type: Application
    Filed: October 11, 2021
    Publication date: December 28, 2023
    Inventors: Subha MUKHERJEE, William P. GALLAGHER, Christopher Robert JAMISON, Carolyn S. WEI, Sergei KOLOTUCHIN, Amarjit SINGH, Nicolas CUNIERE, Chris SFOUGGATAKIS, Adrian ORTIZ, Steven R. WISNIEWSKI, Bin ZHENG, Helen Y. LUO, Sébastien François Emmanuel LEMAIRE, Cyril BEN HAÏM, Kostiantyn CHERNICHENKO, Diego Fernando Domenico BROGGINI, Simon Albert WAGSCHAL, Duy Chi Trung CAO, Karl REUTER, Björn SCHMALZBAUER, Philipp KOSCHKER, Martin D. EASTGATE, Dimitri SKLIAR, Alexander ZHDANKO, Christos XIOURAS, Matthew Penfield MOWER, Ngoc Duc TRAN, Ramdane RAHMANI, Xavier Jean-Marie JUSSEAU, Kiran MATCHA, Luca Alessandro PEREGO
  • Substituted 4-amino-1H-imidazo[4,5-c]quinoline compounds and improved methods for their preparation
    Patent number: 11827597
    Abstract: Improved methods and intermediates thereof for preparing substituted 4-amino-1H-imidazo[4,5-c]quinoline compounds are described. These compounds are useful as NLRP3 modulators.
    Type: Grant
    Filed: November 22, 2022
    Date of Patent: November 28, 2023
    Assignee: INNATE TUMOR IMMUNITY, INC.
    Inventors: Sha Lou, Adrian Ortiz, Christopher Robert Jamison, Eric M. Simmons
  • SYNTHESIS OF 1,2,5-TRI-O-BENZOYL-3-DIBENZYLAMINO-3-DEOXYRIBOSE AS INTERMEDIATE FOR PRODUCING 3'-AMINO-3'-DEOXYADENOSINE AND 3'-AMINO-3'-DEOXYGUANOSINE AND THE PROTECTED DERIVATIVES THEREOF
    Publication number: 20230357306
    Abstract: The invention generally relates to improved processes for the preparation of intermediates of a cyclic dinucleotide which is useful as a STING agonist.
    Type: Application
    Filed: February 5, 2020
    Publication date: November 9, 2023
    Inventors: Changxia Yuan, Michael Anthony Schmidt, Adrian Ortiz, Amanda J. Rogers, Jason J. Zhu, Zhongmin Xu, Miao Yu, Eric M. Simmons, Shulin Wu
  • SUBSTITUTED 4-AMINO-1H-IMIDAZO[4,5-c]QUINOLINE COMPOUNDS AND IMPROVED METHODS FOR THEIR PREPARATION
    Publication number: 20230097144
    Abstract: Improved methods and intermediates thereof for preparing substituted 4-amino-1H-imidazo[4,5-c]quinoline compounds are described. These compounds are useful as NLRP3 modulators.
    Type: Application
    Filed: November 22, 2022
    Publication date: March 30, 2023
    Inventors: Sha Lou, Adrian Ortiz, Christopher Robert Jamison, Eric M. Simmons
  • Substituted 4-amino-1H-imidazo[4,5-c]quinoline compounds and improved methods for their preparation
    Patent number: 11572360
    Abstract: Improved methods and intermediates thereof for preparing substituted 4-amino-1H-imidazo[4,5-c]quinoline compounds are described. These compounds are useful as NLRP3 modulators.
    Type: Grant
    Filed: August 15, 2019
    Date of Patent: February 7, 2023
    Assignee: INNATE TUMOR IMMUNITY, INC.
    Inventors: Sha Lou, Adrian Ortiz, Christopher Robert Jamison, Victor W. Rosso, Mansi S. Shah
  • SYNTHETIC PROCESSES FOR THE PRODUCTION OF 1-((3S,4R)-4-(2,6-DIFLUORO-4-METHOXYPHENYL)-2-OXOPYRROLIDIN-3-YL)-3-PHENYLUREA
    Publication number: 20210395200
    Abstract: Highly efficient processes are provided for preparing key intermediates in the synthesis of compounds (I). The process are broadly applicable and can provide selected components having a variety of substituents. Some intermediates are claimed.
    Type: Application
    Filed: November 15, 2019
    Publication date: December 23, 2021
    Inventors: Adrian Ortiz, Alina Borovika, Sergei Kolotuchin, Michael R. Luzung, Jeffrey A. Nye, Yichen Tan, Serge Zaretsky, Jason J. Zhu, Martin D. Eastgate
  • SUBSTITUTED 4-AMINO-1H-IMIDAZO[4,5-c]QUINOLINE COMPOUNDS AND IMPROVED METHODS FOR THEIR PREPARATION
    Publication number: 20210332040
    Abstract: Improved methods and intermediates thereof for preparing substituted 4-amino-1H-imidazo[4,5-c]quinoline compounds are described. These compounds are useful as NLRP3 modulators.
    Type: Application
    Filed: August 15, 2019
    Publication date: October 28, 2021
    Inventors: Sha Lou, Adrian Ortiz, Rebecca A. Green, Christopher Robert Jamison, Candice Lee Joe, Sergei Kolotuchin, Eric M. Simmons, Neil A. Strotman, Matthew W. Haley, Yichen Tan, Andrew William Glace, Dong Lin, Albert J. DelMonte, Peng Geng, Bahar Inankur, Victor W. Rosso, Mansi S. Shah
  • Methods of producing an HIV maturation inhibitor
    Patent number: 10221208
    Abstract: A method for producing HIV maturation inhibitor compound is set forth using betulin as starting material, and utilizing Lossen rearrangement techniques.
    Type: Grant
    Filed: April 14, 2016
    Date of Patent: March 5, 2019
    Assignee: VIIV HEALTHCARE UK (NO.4) LIMITED
    Inventors: Adrian Ortiz, Maxime Soumeillant, Scott A. Savage, Neil A. Strotman, Martin D. Eastgate, Matthew W. Haley, Jeanne Ho, Jeffrey A. Nye, Zhongmin Xu, Susanne Kiau, Tamas Benkovics, Yichen Tan
  • Process and intermediates for making tubulysin analogs
    Patent number: 10106560
    Abstract: An improved process for making a compound B of the structure wherein n, R1, R2, and R3 are as defined in the specification. Compound B can be used to make tubulysin analogs that are, in turn, useful as anti-cancer agents, particularly when deployed in an antibody-drug conjugate.
    Type: Grant
    Filed: June 15, 2017
    Date of Patent: October 23, 2018
    Assignee: Bristol-Myers Squibb Company
    Inventors: Adrian Ortiz, Carlos A. Guerrero, Bin Zheng, Jason J. Zhu, Michael Anthony Schmidt, Michael R. Luzung, Martin D. Eastgate
  • METHODS OF PRODUCING AN HIV MATURATION INHIBITOR
    Publication number: 20180072691
    Abstract: A method for producing HIV maturation inhibitor compound is set forth using betulin as starting material, and utilizing Lossen rearrangement techniques.
    Type: Application
    Filed: April 14, 2016
    Publication date: March 15, 2018
    Inventors: Adrian ORTIZ, Maxime SOUMEILLANT, Scott A. SAVAGE, Neil A. STROTMAN, Martin D. EASTGATE, Matthew W. HALEY, Jeanne HO, Jeffrey A. NYE, Zhongmin XU, Susanne KIAU, Tamas BENKOVICS, Yichen TAN
  • PROCESS AND INTERMEDIATES FOR MAKING TUBULYSIN ANALOGS
    Publication number: 20170362259
    Abstract: An improved process for making a compound B of the structure wherein n, R1, R2, and R3 are as defined in the specification. Compound B can be used to make tubulysin analogs that are, in turn, useful as anti-cancer agents, particularly when deployed in an antibody-drug conjugate.
    Type: Application
    Filed: June 15, 2017
    Publication date: December 21, 2017
    Inventors: Adrian ORTIZ, Carlos A. GUERRERO, Bin ZHENG, Jason J. ZHU, Michael Anthony SCHMIDT, Michael R. LUZUNG, Martin D. EASTGATE
  • TERT-BUTYL SULPHOXIDE METHOD FOR PRODUCING FESTINAVIR
    Publication number: 20160130260
    Abstract: Tert-butyl sulphoxide method for producing festinavir is set forth.
    Type: Application
    Filed: June 11, 2014
    Publication date: May 12, 2016
    Inventors: Adrian Ortiz, Tamas Benkovics, Martin D. Eastgate
  • Sulfilimine and sulphoxide methods for producing festinavir
    Patent number: 9249171
    Abstract: A process for making the compound of Formula I utilizes the starting compound, together with sulfilimine and sulfoxide process steps later on.
    Type: Grant
    Filed: May 22, 2013
    Date of Patent: February 2, 2016
    Assignee: Bristol-Myers Squibb Company
    Inventors: Adrian Ortiz, Tamas Benkovics, Zhongping Shi, Prashant P. Deshpande, Zhiwei Guo, David R. Kronenthal, Chris Sfouggatakis
  • SULFILIMINE AND SULPHOXIDE METHODS FOR PRODUCING FESTINAVIR
    Publication number: 20150140610
    Abstract: A process for making the compound of Formula I utilizes the starting compound, together with sulfilimine and sulfoxide process steps later on.
    Type: Application
    Filed: May 22, 2013
    Publication date: May 21, 2015
    Inventors: Adrian Ortiz, Tamas Benkovics, Zhongping Shi, Prashant P. Deshpande, Zhiwei Guo, David R. Kronenthal, Chris Sfouggatakis