Patents by Inventor Adrian PELIN

Adrian PELIN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MODIFIED ORTHOPOXVIRUS VECTORS
    Publication number: 20240132913
    Abstract: The disclosure relates to modified orthopoxvirus vectors, as well as methods of using the same for the treatment of various cancers. The disclosure provides modified orthopoxvirus vectors that exhibit various beneficial therapeutic activities, including enhanced oncolytic activity, spread of infection, immune evasion, tumor persistence, capacity for incorporation of exogenous DNA sequences and safety. The viruses we have discovered are also amenable to large scale manufacturing protocols.
    Type: Application
    Filed: September 4, 2023
    Publication date: April 25, 2024
    Applicants: OTTAWA HOSPITAL RESEARCH INSTITUTE, TURNSTONE BIOLOGICS CORP.
    Inventors: John C. Bell, Fabrice Le Boeuf, Michael S. Huh, Matthew Y. Tang, Adrian Pelin, Brian Andrew Keller, Caroline J. Breitbach, Michael F. Burgess, Steven H. Bernstein
  • Modified orthopoxvirus vectors
    Patent number: 11802292
    Abstract: The disclosure relates to modified orthopoxvirus vectors, as well as methods of using the same for the treatment of various cancers. The disclosure provides modified orthopoxvirus vectors that exhibit various beneficial therapeutic activities, including enhanced oncolytic activity, spread of infection, immune evasion, tumor persistence, capacity for incorporation of exogenous DNA sequences and safety. The viruses we have discovered are also amenable to large scale manufacturing protocols.
    Type: Grant
    Filed: January 4, 2019
    Date of Patent: October 31, 2023
    Assignees: OTTAWA HOSPITAL RESEARCH INSTITUTE, TURNSTONE BIOLOGICS CORP.
    Inventors: John C. Bell, Fabrice Le Boeuf, Michael S. Huh, Matthew Y. Tang, Adrian Pelin, Brian Andrew Keller, Caroline J. Breitbach, Michael F. Burgess, Steven H. Bernstein
  • MODIFIED VACCINIA VECTORS
    Publication number: 20230022757
    Abstract: The disclosure relates to modified vaccinia virus vectors derived from the Copenhagen strain of vaccinia virus, as well as methods of using the same for the treatment of various cancers. The disclosure provides modified Copenhagen-derived vaccinia virus vectors that exhibit various beneficial therapeutic activities, including enhanced oncolytic activity, spread of infection, immune evasion, tumor persistence, capacity for incorporation of exogenous DNA sequences, amenability for large scale manufacturing, and safety.
    Type: Application
    Filed: March 14, 2022
    Publication date: January 26, 2023
    Applicant: OTTAWA HOSPITAL RESEARCH INSTITUTE
    Inventors: John C. Bell, Fabrice Le Boeuf, Michael S. Huh, Matthew Y. Tang, Brian Andrew Keller, Adrian Pelin
  • MODIFIED ORTHOPOXVIRUS VECTORS
    Publication number: 20220380799
    Abstract: The disclosure relates to modified orthopoxvirus vectors, as well as methods of using the same for the treatment of various cancers. The disclosure provides modified orthopoxvirus vectors that exhibit various beneficial therapeutic activities, including enhanced oncolytic activity, spread of infection, immune evasion, tumor persistence, capacity for incorporation of exogenous DNA sequences, amenability for large scale manufacturing, and safety.
    Type: Application
    Filed: December 20, 2019
    Publication date: December 1, 2022
    Applicants: OTTAWA HOSPITAL RESEARCH INSTITUTE, TURNSTONE BIOLOGICS CORP.
    Inventors: John C. BELL, Michael S. HUH, Matthew Y. TANG, Adrian PELIN, Caroline J. BREITBACH, Michael F. BURGESS, Steven H. BERNSTEIN
  • MODIFIED ORTHOPOXVIRUS VECTORS
    Publication number: 20220056480
    Abstract: The disclosure relates to modified orthopoxvirus vectors, as well as methods of using the same for the treatment of various cancers. The disclosure provides modified orthopoxvirus vectors that exhibit various beneficial therapeutic activities, including enhanced oncolytic activity, spread of infection, immune evasion, tumor persistence, capacity for incorporation of exogenous DNA sequences, amenability for large scale manufacturing, and safety.
    Type: Application
    Filed: December 20, 2019
    Publication date: February 24, 2022
    Applicants: OTTAWA HOSPITAL RESEARCH INSTITUTE, TURNSTONE BIOLOGICS CORP.
    Inventors: John C. BELL, Michael S. HUH, Matthew Y. TANG, Adrian PELIN, Caroline J. BREITBACH, Michael F. BURGESS, Steven H. BERNSTEIN
  • MODIFIED ORTHOPOXVIRUS VECTORS
    Publication number: 20200392535
    Abstract: The disclosure relates to modified orthopoxvirus vectors, as well as methods of using the same for the treatment of various cancers. The disclosure provides modified orthopoxvirus vectors that exhibit various beneficial therapeutic activities, including enhanced oncolytic activity, spread of infection, immune evasion, tumor persistence, capacity for incorporation of exogenous DNA sequences and safety. The viruses we have discovered are also amenable to large scale manufacturing protocols.
    Type: Application
    Filed: January 4, 2019
    Publication date: December 17, 2020
    Applicants: OTTAWA HOSPITAL RESEARCH INSTITUTE, TURNSTONE BIOLOGICS CORP.
    Inventors: John C. BELL, Fabrice LE BOEUF, Michael S. HUH, Matthew Y. TANG, Adrian PELIN, Brian Andrew KELLER, Caroline J. BREITBACH, Michael F. BURGESS, Steven H. BERNSTEIN
  • MODIFIED VACCINIA VECTORS
    Publication number: 20200385758
    Abstract: The disclosure relates to modified vaccinia virus vectors derived from the Copenhagen strain of vaccinia virus, as well as methods of using the same for the treatment of various cancers. The disclosure provides modified Copenhagen-derived vaccinia virus vectors that exhibit various beneficial therapeutic activities, including enhanced oncolytic activity, spread of infection, immune evasion, tumor persistence, capacity for incorporation of exogenous DNA sequences, amenability for large scale manufacturing, and safety.
    Type: Application
    Filed: January 4, 2019
    Publication date: December 10, 2020
    Applicant: OTTAWA HOSPITAL RESEARCH INSTITUTE
    Inventors: John C. BELL, Fabrice LE BOEUF, Michael S. HUH, Matthew Y. TANG, Brian Andrew KELLER, Adrian PELIN