Abstract: One variation of a dynamic tactile interface includes a tactile layer defining a peripheral region and a deformable region adjacent the peripheral region; a substrate coupled to the peripheral region, a fluid conduit adjacent the deformable region, a fluid channel fluidly coupled to the fluid conduit, and a via fluidly coupled to the fluid channel and passing through the back surface; a bladder fluidly coupled to the via and the substrate; a structure adjacent a first side of the bladder; and a platen adjacent a second side of the bladder opposite the first side and compressing the bladder against the structure substantially perpendicular the longitudinal axis of the bladder and substantially parallel the substrate to displace fluid from the bladder and into the fluid channel to transition the deformable region from a retracted setting into an expanded setting.

Abstract: One variation of a dynamic tactile interface includes a tactile layer defining a peripheral region and a deformable region adjacent the peripheral region; a substrate coupled to the peripheral region, a fluid conduit adjacent the deformable region, a fluid channel fluidly coupled to the fluid conduit, and a via fluidly coupled to the fluid channel and passing through the back surface; a bladder fluidly coupled to the via and the substrate; a structure adjacent a first side of the bladder; and a platen adjacent a second side of the bladder opposite the first side and compressing the bladder against the structure substantially perpendicular the longitudinal axis of the bladder and substantially parallel the substrate to displace fluid from the bladder and into the fluid channel to transition the deformable region from a retracted setting into an expanded setting.

Abstract: A dynamic tactile interface includes a dynamic tactile layer and a manual fluid actuator. The manual fluid actuator includes a displacement device including a bladder, a platen adjacent the bladder, an elongated member coupled to the platen, and a rotary actuator, the elongated member and the rotary actuator translating rotation of the rotary actuator into translation of the platen, the platen compressing the bladder in response to rotation of the rotary actuator in a first direction and expanding the bladder in response to rotation of the rotary actuator in a second direction opposite the first direction.

Abstract: The dynamic tactile interface includes: a tactile layer defining a peripheral region and a deformable region adjacent the peripheral region and operable between a retracted setting and an expanded setting; a substrate including an attachment surface and coupled to the peripheral region and defining a fluid conduit adjacent the deformable region and a fluid channel fluidly coupled to the fluid conduit; a border region proximal a periphery of the substrate and defining a cavity configured to receive an instrument, the cavity supporting the instrument in a first configuration and releasing the instrument in a second configuration; and a bladder fluidly coupled to the fluid channel and coupled to the cavity, the instrument compressing a portion of the bladder in the first configuration to displace fluid from the bladder into the fluid channel to transition the deformable region from the retracted setting to the expanded setting.

Abstract: The dynamic tactile interface includes: a tactile layer defining a peripheral region and a deformable region adjacent the peripheral region and operable between a retracted setting and an expanded setting; a substrate including an attachment surface and coupled to the peripheral region and defining a fluid conduit adjacent the deformable region and a fluid channel fluidly coupled to the fluid conduit; a border region proximal a periphery of the substrate and defining a cavity configured to receive an instrument, the cavity supporting the instrument in a first configuration and releasing the instrument in a second configuration; and a bladder fluidly coupled to the fluid channel and coupled to the cavity, the instrument compressing a portion of the bladder in the first configuration to displace fluid from the bladder into the fluid channel to transition the deformable region from the retracted setting to the expanded setting.

Abstract: One variation of a dynamic tactile interface includes a tactile layer defining a peripheral region and a deformable region adjacent the peripheral region; a substrate coupled to the peripheral region, a fluid conduit adjacent the deformable region, a fluid channel fluidly coupled to the fluid conduit, and a via fluidly coupled to the fluid channel and passing through the back surface; a bladder fluidly coupled to the via and the substrate; a structure adjacent a first side of the bladder; and a platen adjacent a second side of the bladder opposite the first side and compressing the bladder against the structure substantially perpendicular the longitudinal axis of the bladder and substantially parallel the substrate to displace fluid from the bladder and into the fluid channel to transition the deformable region from a retracted setting into an expanded setting.

Abstract: A compound of formula 1 and/or its salts, tautomers or solvates is used to treat hematological malignancies. In an embodiment, an organic acid salt of compound 1 is provided for general use in treatment of neoplasms, and in a further embodiment the salt is stabilized with carbohydrate.

Abstract: The invention is related to phosphorus substituted anti-viral inhibitory compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

Abstract: The invention is related to phosphorus substituted purine nucleoside phosphorylase inhibitory compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

Abstract: The invention is related to phosphorus substituted therapeutic agents, compositions containing such phosphorus substituted agents, and therapeutic methods that include the administration of such phosphorus substituted agents, as well as to processes and intermediates useful for preparing such agents.

Abstract: The invention is related to phosphorus substituted anti-inflammatory compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

Abstract: The invention is related to phosphorus substituted anti-cancer compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

Abstract: The invention is related to phosphonate substituted compounds having immuno-modulatory activity, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

Abstract: The invention is related to phosphorus substituted nucleoside compounds and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

Abstract: The invention is related to phosphorus substituted compounds with antiviral activity, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

Abstract: An updateable enterprise resource planning system to coordinate and reconcile a seller's, a buyer's, a supplier's and a third party logistic supplier's business systems into a single updateable central system hosted by a seller. The seller is provided with information to forecast, plan, and coordinate present and future purchases in a timely and efficient manner. The buyer, seller, and third party logistics supplier are also provided with updated information to use to ship product to the buyer in a timely and efficient manner. A second aspect of the present invention provides the buyer with access to a web server controlled by the seller, wherein the buyer can link up with a third party logistic supplier web site coupled to said web server to monitor shipping status of the shipping orders. This allows the buyer to facilitate planning for arrival of shipments to improve efficiency, leading in potential cost savings.