Abstract: Method for performing a bioprocess on liquid immune cell cultures comprising a sequence of processing steps, wherein the bioprocess is being performed on an integrated bioprocessing system, wherein the sequence of processing steps comprises at least one unit operation, which is being performed within a unit operation station of the integrated bioprocessing system. Cartridges, that have been preconfigured with a cartridge fluidic structure with respect to the respective unit operation, are being stored in a cartridge storage unit of the unit operation station and that for performing the respective unit operation, one of the cartridges is being transported from a storage transfer location in a cartridge storage unit of the unit operation station to a drive location of a cartridge drive unit of the unit operation station by a local transport mechanism of the unit operation station and is being brought into operative coupling with the cartridge drive unit.

Abstract: Method for performing a bioprocess to obtain processed cell cultures, wherein the processed cell cultures are destined for autologous or allogenic cell therapy, wherein the bioprocess is performed on an integrated bioprocessing system, wherein the bioprocess comprises a sequence of processing steps, wherein the processing steps each comprise at least one operation, wherein the bioprocess system comprises a base structure and preconfigurable cartridges, wherein the bioprocess system performs operations of the bioprocess via an interaction of the base structure with the cartridges, wherein the cartridges and the base structure comprise matching standardized interfaces for an interaction of the base structure with the respective cartridge, wherein the bioprocess system performs at least two operations of the bioprocess inside at least two differently preconfigured cartridges by an interaction of the base structure with the cartridges via the same base structure interface and/or identical base structure interface

Abstract: Method for performing bioprocesses on cell cultures. The bioprocesses performed on an integrated bioprocessing system (IBS) transferring a medium in the bioprocess, in particular the cell cultures, through tubes. The IBS includes a tube connection system (tcs) connecting tubes of the IBS by welding. A first tube, first tube holder and first fluidic structure receiving and/or providing the medium are carried by a movable first carrier. The first tube is held by the first tube holder fluidically connected to the first fluidic structure. The first carrier, first tube, first tube holder and the first fluidic structure are transported to a welding location within the IBS. A welding routine at the welding location includes the tes connecting the first tube and a second tube forming a tube connection. The IBS transfers the medium from or to the first fluidic structure of the first carrier through the tube connection after welding.

Abstract: A computer-implemented method for spectroscopic analysis of biological material is provided that includes analyzing samples of biological material from a plurality of sources, and delivering samples of biological material to at least one flow cell for spectroscopy, and determining whether the spectroscopic analysis for each sample of the plurality of samples is or is predicted to be ambiguous in that it is affected by at least two non-discriminable factors. If such a determination is made, a disambiguating step can be performed.

Abstract: An auto-aligning cable sensor for performing measurements on a medium contained in a vessel is provided. The cable sensor includes a cable which has an end sensor and which is adapted to be carried by a mounting fixture. The mounting fixture and the vessel are movable into a measurement position relative to each other such that a contact face of the end sensor is held in alignment against a surface of the vessel by a pressing force, thereby enabling the end sensor to sense a characteristic of the medium contained in the vessel. The cable sensor further includes an elastically deformable coupling member which is arranged to mediate transfer of the pressing force from the mounting fixture to the cable and thence to the end sensor when the mounting fixture and the vessel are moved into the measurement position.

Abstract: The present application generally pertains to scaling of a production process to produce a chemical, pharmaceutical and/or biotechnological product and/or of a production state of a respective production equipment.

Abstract: A computer-implemented method for spectroscopic analysis of biological material is provided that includes analyzing samples of biological material from a plurality of sources, and delivering samples of biological material to at least one flow cell for spectroscopy, and determining whether the spectroscopic analysis for each sample of the plurality of samples is or is predicted to be ambiguous in that it is affected by at least two non-discriminable factors. If such a determination is made, a disambiguating step can be performed.

Abstract: A computer-implemented method of determining at least one recipe for a production process to produce a chemical, pharmaceutical and/or biotechnological product is provided, wherein the production process is defined by a plurality of steps specified by recipe parameter(s) controlling an execution of the production process and a recipe comprises the plurality of steps defining the production process.

Abstract: A computer-implemented method for spectroscopic analysis of biological material is provided that includes analyzing samples of biological material from a plurality of sources, and delivering samples of biological material to at least one flow cell for spectroscopy, and determining whether the spectroscopic analysis for each sample of the plurality of samples is or is predicted to be ambiguous in that it is affected by at least two non-discriminable factors. If such a determination is made, a disambiguating step can be performed.

Abstract: The present application generally pertains to scaling of a production process to produce a chemical, pharmaceutical and/or biotechnological product and/or of a production state of a respective production equipment.

Abstract: The present application generally pertains to scaling of a production process to produce a chemical, pharmaceutical and/or biotechnological product and/or of a production state of a respective production equipment.

Abstract: Described is an automated transport unit for use in a laboratory environment the automated transport unit comprising a drive mechanism for moving the automated transport unit, a control system for controlling operation of the automated transport unit, a power supply for powering the automated transport unit, and a storage compartment configured to hold a material obtained from a fluid storage vessel and/or to be delivered to a fluid storage vessel. Also described is a system comprising an automated transport unit and a fluid storage vessel.

Abstract: A computer-implemented method for spectroscopic analysis of biological material is provided that includes analyzing samples of biological material from a plurality of sources, and delivering samples of biological material to at least one flow cell for spectroscopy, and determining whether the spectroscopic analysis for each sample of the plurality of samples is or is predicted to be ambiguous in that it is affected by at least two non-discriminable factors. If such a determination is made, a disambiguating step can be performed.

Abstract: An auto-aligning cable sensor for performing measurements on a medium contained in a vessel is provided. The cable sensor includes a cable which has an end sensor and which is adapted to be carried by a mounting fixture. The mounting fixture and the vessel are movable into a measurement position relative to each other such that a contact face of the end sensor is held in alignment against a surface of the vessel by a pressing force, thereby enabling the end sensor to sense a characteristic of the medium contained in the vessel. The cable sensor further includes an elastically deformable coupling member which is arranged to mediate transfer of the pressing force from the mounting fixture to the cable and thence to the end sensor when the mounting fixture and the vessel are moved into the measurement position.

Abstract: The present application generally pertains to scaling of a production process to produce a chemical, pharmaceutical and/or biotechnological product and/or of a production state of a respective production equipment.

Abstract: Described is an automated transport unit for use in a laboratory environment the automated transport unit comprising a drive mechanism for moving the automated transport unit, a control system for controlling operation of the automated transport unit, a power supply for powering the automated transport unit, and a storage compartment configured to hold a material obtained from a fluid storage vessel and/or to be delivered to a fluid storage vessel. Also described is a system comprising an automated transport unit and a fluid storage vessel.