Patents by Inventor Adrian Wai-Hing Cheung

Adrian Wai-Hing Cheung has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Diacylglycerol Acyltransferase Inhibitors
    Publication number: 20090170864
    Abstract: Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, obesity, type II diabetes mellitus and metabolic syndrome.
    Type: Application
    Filed: May 1, 2008
    Publication date: July 2, 2009
    Inventors: David Robert Bolin, Adrian Wai-Hing Cheung, Fariborz Firooznia, Matthew Michael Hamilton, Lee Apostle McDermott, Yimin Qian, Jenny Tan, Weiya Yun
  • Diacylglycerol Acyltransferase Inhibitors
    Publication number: 20090105273
    Abstract: Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, obesity, type II diabetes mellitus and metabolic syndrome.
    Type: Application
    Filed: May 1, 2008
    Publication date: April 23, 2009
    Inventors: David Robert Bolin, Adrian Wai-Hing Cheung, Fariborz Firooznia, Matthew Michael Hamilton, Lee Aopstle McDermott, Yimin Qian, Jenny Tan, Weiya Yun
  • Quinazoline Protein Tyrosine Phosphatase Inhibitors
    Publication number: 20090105477
    Abstract: The present invention comprises aminoquinazoline compounds of the general formula I: wherein X is an unsubstituted or substituted phenyl, or is an unsubstituted or substituted 5 or 6 membered heteroaromatic ring. The compounds of the present invention are potent inhibitors of PTP1B. Accordingly, the invention also encompasses pharmaceutical compositions and methods of treating or preventing PTP-1B mediated diseases, including diabetes, obesity, and diabetes-related diseases.
    Type: Application
    Filed: October 30, 2008
    Publication date: April 23, 2009
    Inventors: Steven Joseph Berthel, Adrian Wai-Hing Cheung, Kshitij Chhabilbhai Thakkar, Weiya Yun
  • Diacylglycerol Acyltransferase Inhibitors
    Publication number: 20090099201
    Abstract: Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, obesity, type II diabetes mellitus and metabolic syndrome.
    Type: Application
    Filed: May 1, 2008
    Publication date: April 16, 2009
    Inventors: David Robert Bolin, Adrian Wai-Hing Cheung, Fariborz Firooznia, Matthew Michael Hamilton, Lee Apostle McDermott, Yimin Qian, Jenny Tan, Weiya Yun
  • Diacylglycerol Acyltransferase Inhibitors
    Publication number: 20090093497
    Abstract: Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, obesity, type II diabetes mellitus and metabolic syndrome.
    Type: Application
    Filed: May 1, 2008
    Publication date: April 9, 2009
    Inventors: David Robert Bolin, Adrian Wai-Hing Cheung, Fariborz Firooznia, Matthew Micheal Hamilton, Lee Apostle McDermott, Yimin Qian, Jenny Tan, Weiya Yun
  • DIACYLGLYCEROL ACYLTRANSFERASE INHIBITORS
    Publication number: 20090076275
    Abstract: Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, obesity, type II diabetes mellitus and metabolic syndrome.
    Type: Application
    Filed: September 10, 2008
    Publication date: March 19, 2009
    Inventors: David Robert Bolin, Jianping Cai, Adrian Wai-Hing Cheung, Robert Alan Goodnow, JR., Matthew Michael Hamilton, Shiming Li, Lee Apostle McDermott, Weiya Yun
  • PYRIDOPYRIMIDINE PROTEIN TYROSINE PHOSPHATASE INHIBITORS
    Publication number: 20090062276
    Abstract: The present invention comprises pyridopyrimidinediamine compounds of the general formula I: The compounds of the present invention are potent inhibitors of PTP1B. Accordingly, the invention also encompasses pharmaceutical compositions and methods of treating or preventing PTP-1B mediated diseases, including diabetes, obesity, and diabetes-related diseases.
    Type: Application
    Filed: October 28, 2008
    Publication date: March 5, 2009
    Inventors: Steven Joseph Berthel, Adrian Wai-Hing Cheung, Kyungjin Kim, Shiming Li, Kshitij Chhabilbhai Thakkar, Weiya Yun
  • Selective Linear Peptides with Melanocortin-4 Receptor (MC4-R) Agonist Activity
    Publication number: 20080177036
    Abstract: Peptides of formulae I, II and III that selectively activate melanocortin-4 (MC-4) receptor activity.
    Type: Application
    Filed: March 14, 2008
    Publication date: July 24, 2008
    Inventors: Li Chen, Adrian Wai-Hing Cheung, Xin-Jie Chu, Waleed Danho, Joseph Swistok, Keith Alan Yagaloff
  • Thiazolo-pyrimidine/pyridine urea derivatives
    Publication number: 20070270433
    Abstract: There are presented compounds of the formula or a pharmaceutically acceptable salt thereof, which are active adenosine A2B receptor antagonists and useful in the treatment of diabetes, diabetic retinopathy, asthma and diarrhea.
    Type: Application
    Filed: May 11, 2007
    Publication date: November 22, 2007
    Inventors: John A. Brinkman, Adrian Wai-Hing Cheung, Fariborz Firooznia, Kevin Richard Guertin, Nicholas Marcopulos, Lida Qi, Jagdish Kumar Racha, Ramakanth Sarabu, Jenny Tan, Jefferson Wright Tilley
  • Diaminopyrroloquinazolines compounds as protein tyrosine phosphatase inhibitors
    Patent number: 7262297
    Abstract: The invention relates to pyrimido[5,4-e][1,2,4]triazine-5,7-diamine compounds which are useful for inhibiting protein tyrosine phosphatases, particularly PTP1B, and are useful for lowering blood glucose concentrations in mammals.
    Type: Grant
    Filed: April 30, 2004
    Date of Patent: August 28, 2007
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Steven Joseph Berthel, Adrian Wai-Hing Cheung, Kyungjin Kim, Kshitij Chhabilbhai Thakkar, Weiya Yun
  • Selective cyclic peptides with melanocortin-4 receptor (MC4-R) agonist activity
    Patent number: 7045591
    Abstract: Peptides cyclized via disulfide or lactam bridges are disclosed. The peptides exhibit melanocortin-4 receptor agonist activity and are useful for treating obesity.
    Type: Grant
    Filed: August 27, 2001
    Date of Patent: May 16, 2006
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Li Chen, Adrian Wai-Hing Cheung, Xin-Jie Chu, Waleed Danho, Joseph Swistok, Yao Wang, Keith Alan Yagaloff
  • Diaminopyrroloquinazolines compounds as protein tyrosine phosphatase inhibitors
    Publication number: 20040235872
    Abstract: The invention relates to pyrimido[5,4-e][1,2,4]triazine-5,7-diamine compounds which are useful for inhibiting protein tyrosine phosphatases, particularly PTP1B, and are useful for lowering blood glucose concentrations in mammals.
    Type: Application
    Filed: April 30, 2004
    Publication date: November 25, 2004
    Inventors: Steven Joseph Berthel, Adrian Wai-Hing Cheung, Kyungjin Kim, Kshitij Chhabilbhai Thakkar, Weiya Yun
  • Selective linear peptides with melanocor tin-4 receptor (MC4-R) agonist activity
    Publication number: 20030229200
    Abstract: Peptides of formulae I, II and III that selectively activate melanocortin-4 (MC-4) receptor activity.
    Type: Application
    Filed: May 9, 2003
    Publication date: December 11, 2003
    Inventors: Li Chen, Adrian Wai-Hing Cheung, Xin-Jie Chu, Waleed Danho, Joseph Swistok, Keith Alan Yagaloff
  • Selective linear peptides with melanocortin-4 receptor (MC4-R) agonist activity
    Patent number: 6600015
    Abstract: Peptides that selectively stimulate melanocortin-4 (MC-4) receptor activity are disclosed.
    Type: Grant
    Filed: March 19, 2001
    Date of Patent: July 29, 2003
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Li Chen, Adrian Wai-Hing Cheung, Xin-Jie Chu, Waleed Danho, Joseph Swistok, Keith Alan Yagaloff
  • Selective cyclic peptides with melanocortin-4 receptor (MC4-R) agonist activity
    Publication number: 20020143141
    Abstract: Peptides cyclized via disulfide or lactam bridges having melanocortin-4 receptor (MC4-R) agonist activity useful for treatment of obesity.
    Type: Application
    Filed: August 27, 2001
    Publication date: October 3, 2002
    Inventors: Li Chen, Adrian Wai-Hing Cheung, Xin-Jie Chu, Waleed Danho, Joseph Swistok, Yao Wang, Keith Alan Yagaloff
  • 7-aryl-6(Z)-heptatrienoic acid retinamides
    Patent number: 6310247
    Abstract: Novel trienoic retinoid compounds of with apoptotic activity useful for the prevention and treatment of cancer.
    Type: Grant
    Filed: December 14, 1999
    Date of Patent: October 30, 2001
    Assignee: Hoffmann-LA Roche Inc.
    Inventors: Adrian Wai-Hing Cheung, Stephen B. Ferguson, Louise Helen Foley, Allen John Lovey