Abstract: Provided are TCRs (e.g., TCRs that bind to NY-ESO-1), cells and pharmaceutical compositions comprising these TCRs, nucleic acids encoding these TCRs, expression vectors and host cells for making these TCRs, and methods of treating a subject using these TCRs.

Abstract: Systems and methods for determining relative importance of one or more variables in a non-parametric model include: receiving, raw values of the variables corresponding to one or more entities; processing the raw values using a statistical model to obtain probability values for the variables and an overall prediction value for each entity; determining a plurality of cumulative distributions for the variables based on the raw values and the number of entities having a specific raw value; grouping the variables into a plurality of equally sized buckets based on the cumulative distributions; determining a mean probability value for each bucket; assigning a rank number for each bucket based on the mean probability values; compiling a table for the entities based on the raw values and the buckets corresponding to the raw values; and determining the relative importance of the variables for the entities based on the rank numbers.

Abstract: A method for laser welding two coated workpieces includes positioning an upper workpiece and a lower workpiece on top of each other and passing a first laser beam over the upper and lower workpieces from a side of the upper workpiece so as to at least partially evaporate the respective coating of each of the workpieces on their facing sides along a depletion trace. A second laser beam is passed over the workpieces from the side of the upper workpiece so as to melt a material of the two workpieces within the depletion trace, and thereby weld the workpieces to one another. In the first laser passing, the first laser beam melts the material of the upper workpiece, so that a web of non-melted material of the upper workpiece remaining between the melted material of the upper workpiece and the facing side of the upper workpiece.

Abstract: Systems and methods for determining relative importance of one or more variables in a non-parametric model include: receiving, raw values of the variables corresponding to one or more entities; processing the raw values using a statistical model to obtain probability values for the variables and an overall prediction value for each entity; determining a plurality of cumulative distributions for the variables based on the raw values and the number of entities having a specific raw value; grouping the variables into a plurality of equally sized buckets based on the cumulative distributions; determining a mean probability value for each bucket; assigning a rank number for each bucket based on the mean probability values; compiling a table for the entities based on the raw values and the buckets corresponding to the raw values; and determining the relative importance of the variables for the entities based on the rank numbers.

Abstract: Systems and methods for determining relative importance of one or more variables in a non-parametric model include: receiving, raw values of the variables corresponding to one or more entities; processing the raw values using a statistical model to obtain probability values for the variables and an overall prediction value for each entity; determining a plurality of cumulative distributions for the variables based on the raw values and the number of entities having a specific raw value; grouping the variables into a plurality of equally sized buckets based on the cumulative distributions; determining a mean probability value for each bucket; assigning a rank number for each bucket based on the mean probability values; compiling a table for the entities based on the raw values and the buckets corresponding to the raw values; and determining the relative importance of the variables for the entities based on the rank numbers.

Abstract: A flexible closure, for use in an alarm system is provided in which a conductive sensing element is interlaced with fiber matrix material to provide a network over at least part of the closure. The interlacing is preferably by means of knitting a conductive wire together with a yarn which forms the matrix of the closure. The closure may further include a protective outer layer on one or both faces of the closure.