Patents by Inventor Adriana Cornelia Maria Noordermeer-Van Der Haak

Adriana Cornelia Maria Noordermeer-Van Der Haak has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Yeast cells comprising at least two copies of a desired gene integrated into the chromosomal genome at more than one non-ribosomal RNA encoding domain, particularly with Kluyveromyces
    Patent number: 6265186
    Abstract: The present invention provides for a yeast cell comprising at least two copies of a desired gene integrated into its chromosomal genome, wherein said genome comprises at least two DNA domains suitable for integration of one or more copies of said desired gene, which domains share substantial sequence homology and are non-ribosomal RNA encoding DNA domains, and wherein at least two of said substantially homologous non-ribosomal RNA encoding DNA domains have at least one copy of the said desired gene integrated. The invention also provides methods for making yeast cells according to the invention, as well as the use thereof for making a protein, a peptide or a metabolite.
    Type: Grant
    Filed: December 10, 1999
    Date of Patent: July 24, 2001
    Assignee: DSM N.V.
    Inventors: Bart Willem Swinkels, Albert Johannes Joseph Van Ooijen, Adriana Cornelia Maria Noordermeer-Van Der Haak