Patents by Inventor Adriano Aguzzi

Adriano Aguzzi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240150449
    Abstract: The present invention relates to antibodies, and antigen binding fragments thereof, that specifically bind to the pathological form of TDP-43, which characterizes various TDP-43 proteinopathies. The antibodies, and antigen binding fragments thereof, decrease TDP-43 aggregation observed under pathological conditions. The invention also relates to nucleic acids that encode, and to cells that express such antibodies and antibody fragments. In addition, the invention relates to the use of the antibodies and antibody fragments in the diagnosis, treatment and prevention of TDP-43 proteinopathies.
    Type: Application
    Filed: March 10, 2022
    Publication date: May 9, 2024
    Inventors: Dimitri BIELI, Natascha WUILLEMIN, Niccolo PENGO, Tiziana Maria SONATI, Pierre DE ROSSI, Magdalini POLYMENIDOU, Marc EMMENEGGER, Adriano AGUZZI
  • Publication number: 20220372117
    Abstract: The present invention generally relates to antibodies or binding fragments thereof capable of binding an allergen, in particular a food allergen as well as pharmaceutical compositions comprising such antibodies or binding fragments thereof for the treatment of allergy, in particular food allergy. In addition the invention relates to methods for evaluating the capacity of a candidate antibody or binding fragment thereof to inhibit allergen binding/and/or allergen-induced activity in a human and methods of detecting or quantifying whether an allergen is present in a sample.
    Type: Application
    Filed: April 6, 2022
    Publication date: November 24, 2022
    Inventors: Adriano AGUZZI, Natascha WUILLEMIN, Tiziana SONATI, Dimitri BIELI
  • Publication number: 20200199207
    Abstract: The present invention generally relates to antibodies or binding fragments thereof capable of binding an allergen, in particular a food allergen as well as pharmaceutical compositions comprising such antibodies or binding fragments thereof for the treatment of allergy, in particular food allergy. In addition the invention relates to methods for evaluating the capacity of a candidate antibody or binding fragment thereof to inhibit allergen binding/and/or allergen- induced activity in a human and methods of detecting or quantifying whether an allergen is present in a sample.
    Type: Application
    Filed: June 20, 2018
    Publication date: June 25, 2020
    Inventors: Adriano AGUZZI, Natascha WUILLEMIN, Tiziana SONATI, Dimitri BIELI
  • Publication number: 20110256131
    Abstract: The present invention relates to a method of preventing and treating chronic hepatitis and other liver diseases comprising administering a blocker of Light, LT?1?2, LT?2?1 or LT?R, and the use of such blockers in said prevention and treatment and in the manufacture of medicaments for preventing and treating chronic hepatitis and other liver diseases.
    Type: Application
    Filed: October 14, 2009
    Publication date: October 20, 2011
    Applicant: UNIVERSITAET ZUERICH
    Inventors: Mathias Heikenwaelder, Adriano Aguzzi
  • Publication number: 20080287348
    Abstract: The present invention relates to a soluble hybrid protein, comprising at least a first polypeptide sequence derived from a prion protein PrPc that is capable of binding a protein responsible for transmissible spongiform encephalitis (PrPSc), and a second polypeptide sequence (tag), wherein said hybrid protein does not comprise a functional membrane anchor moiety. Also, the present invention is directed to the use of said hybrid proteins for the diagnosis of transmissible spongiform encephalopathies. In addition, the present invention relates to the use of said hybrid protein, a nucleic acid encoding said hybrid protein, a vector, and/or a host cell comprising a nucleic acid encoding said hybrid protein for the preparation of a medicament for the prevention or treatment of transmissible spongiform encephalopathies (TSEs).
    Type: Application
    Filed: March 12, 2004
    Publication date: November 20, 2008
    Applicant: University of Zuerich
    Inventors: Adriano Aguzzi, Nicolas Genoud, Alex Raeber
  • Publication number: 20080063600
    Abstract: B-cells have been identified as being the crucial carriers of infectivity in the spread of transmissible spongiform encephalopathy within an infected organism. In a second step, B-cells may infect further components_of the immune system, e.g. T-cells. Accordingly, the present invention provides B-cell and T-cell specific ligands for the use in diagnostics and therapeutics for transmissible spongiform encephalopathy and provides methods for the manufacture of non-infective blood products and tissue derived products. Thus, the present invention provides medicaments comprising B-cell and/or T-cell depletants, for the treatment of pathologies where the depletion of B-cells and/or T-cells, and more particularly of tse-infected B-cells and/or T-cells is therapeutically effective.
    Type: Application
    Filed: September 14, 2007
    Publication date: March 13, 2008
    Applicant: ABBOTT LABORATORIES
    Inventors: Adriano Aguzzi, Michael Klein, Alex Raeber, Charles Weissmann, Rolf Zinkernagel
  • Publication number: 20020004586
    Abstract: Disclosed are methods and tools for the concentration and detection as well as quantification of pathological prion proteins as well as agents to be used in said detection and/or in the prevention or treatment of prion diseases. Said agents are factors with prion binding activities found in blood serum and blood plasma.
    Type: Application
    Filed: April 23, 2001
    Publication date: January 10, 2002
    Inventors: Adriano Aguzzi, Michael Boris Fischer
  • Publication number: 20010053533
    Abstract: Disclosed are methods and tools for the concentration and detection as well as quantification of pathological prion proteins as well as agents to be used in said detection and/or in the prevention or treatment of prion diseases. Said agents are factors with prion binding activities found in blood serum and blood plasma.
    Type: Application
    Filed: July 5, 2001
    Publication date: December 20, 2001
    Inventors: Adriano Aguzzi, Michael Boris Fischer