Patents by Inventor Adriano BAUER

Adriano BAUER has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MACROCYCLIC COMPOUNDS AND METHODS OF USE
    Publication number: 20260174769
    Abstract: The present disclosure provides compounds useful for the inhibition of KRAS G12D, G12V, G12A, G12S, G13D, Q61H, Q61L or G12C. The compounds have a general Formula I? (I?) wherein the variables of Formula I? are defined herein. This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, cancer.
    Type: Application
    Filed: November 14, 2023
    Publication date: June 25, 2026
    Applicant: AMGEN INC.
    Inventors: Ryan Paul Wurz, Yunxiao LI, Primali Vasundera NAVARATNE, Jose M. MEDINA, Ning CHEN, Liping PETTUS, Xiaofen LI, John STELLWAGEN, Kexue LI, Brian Alan LANMAN, Michael M. YAMANO, Wei ZHAO, Benjamin WIGMAN, Albert K. AMEGADZIE, Fabien EMMETIERE, Christopher P. MOHR, Aaron C. SIEGMUND, Rene RAHIMOFF, Zhichen WU, Adriano BAUER, Andrew SMALIGO, Quentin Tercenio, Qingyian Liu, Shon K. Booker, Jeffrey Jackson
  • COMPOUNDS AS MODULATORS OF STAT6 AND USES THEREOF
    Publication number: 20260166047
    Abstract: Disclosed herein are compounds useful for the inhibition of STAT6. The compounds have a general Formula (I) or (II) or pharmaceutically acceptable salts thereof, wherein the variables of Formula (I) and (II) are as defined herein. Also provided herein are pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, diseases/disorders related to the activity of STAT6, such as an allergic disease or an inflammatory disease, including but not limited to atopic dermatitis or bronchial asthma. Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula (I) and (II).
    Type: Application
    Filed: December 16, 2025
    Publication date: June 18, 2026
    Applicant: AMGEN INC.
    Inventors: Liping H. PETTUS, Ana Sydelle BULGER, John Charles STELLWAGEN, Fabien EMMETIERE, Thomas FLAGSTAD, Emil GLIBSTRUP, Jeffrey JACKSON, Qingyian LIU, Quentin TERCENIO, Primali Vasundera NAVARATNE, Adriano BAUER, Slavko RAST, Andrew SMALIGO, Yujia TAO, Zhichen WU, Ningxin XU, John Gordon ALLEN, Dora TOLEDO WARSHAVIAK, Mona SHARAFI, Jason YU, Garrick Paul SMITH, Loris MORETTI, Visnja POLJAK, Adili ALAFATE, Matthew John COOK, Imelda Hot, David Huang, Jose Miguel MEDINA, Milauni Mehta UNDURTY, Cesar Nicolas PRIETO KULLMER, Hui-Ling WANG, Jingjing XIE, Nuria A. TAMAYO, Alexander James Pickrell, Minghao Wang, Wenhan Zhang
  • Macrocyclic compounds and methods of use
    Patent number: 12570672
    Abstract: The present disclosure provides compounds useful for the inhibition of KRAS G12D, G12V, G12A, G12S, G13D, Q61H, Q61L or G12C. The compounds have a general Formula I?: wherein the variables of Formula I? are defined herein. This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, cancer.
    Type: Grant
    Filed: March 25, 2024
    Date of Patent: March 10, 2026
    Inventors: Ryan Paul Wurz, Yunxiao Li, Liping Pettus, Brian Alan Lanman, Michael M. Yamano, Wei Zhao, Benjamin Wigman, Adriano Bauer, Andrew Smaligo, Shon K. Booker, John Stellwagen
  • MACROCYCLIC COMPOUNDS AND METHODS OF USE
    Publication number: 20250304599
    Abstract: The present disclosure provides compounds useful for the inhibition of KRAS G12D, G12V, G12A, G12S, G13D, Q61H, Q61L or G12C. The compounds have a general Formula I?: wherein the variables of Formula I? are defined herein. This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, cancer.
    Type: Application
    Filed: October 30, 2024
    Publication date: October 2, 2025
    Applicant: AMGEN INC.
    Inventors: Ryan Paul Wurz, Yunxiao LI, Primali Vasundera NAVARATNE, Jose M. MEDINA, Ning CHEN, Liping PETTUS, Xiaofen LI, John STELLWAGEN, Kexue LI, Brian Alan LANMAN, Michael M. YAMANO, Wei ZHAO, Benjamin WIGMAN, Fabien EMMETIERE, Albert K. AMEGADZIE, Christopher P. MOHR, Aaron C. SIEGMUND, Rene RAHIMOFF, Zhichen WU, Adriano BAUER, Andrew SMALIGO, Quentin Tercenio, Qingyian Liu, Shon K. Booker, Jeffrey Jackson
  • MACROCYCLIC COMPOUNDS AND METHODS OF USE
    Publication number: 20250236631
    Abstract: The present disclosure provides compounds useful for the inhibition of KRAS G12D, G12V, G12A, G12S, G13D, Q61H, Q61L or G12C. The compounds have a general Formula I?: wherein the variables of Formula I? are defined herein. This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, cancer.
    Type: Application
    Filed: April 11, 2025
    Publication date: July 24, 2025
    Applicant: AMGEN INC.
    Inventors: Ryan Paul Wurz, Yunxiao LI, Primali Vasundera NAVARATNE, Jose M. MEDINA, Ning CHEN, Liping PETTUS, Xiaofen LI, John STELLWAGEN, Kexue LI, Brian Alan LANMAN, Michael M. YAMANO, Wei ZHAO, Benjamin WIGMAN, Fabien EMMETIERE, Albert K. AMEGADZIE, Christopher P. MOHR, Aaron C. SIEGMUND, Rene RAHIMOFF, Zhichen WU, Adriano BAUER, Andrew SMALIGO, Quentin Tercenio, Qingyian Liu, Shon K. Booker, Jeffrey Jackson
  • MACROCYCLIC COMPOUNDS AND METHODS OF USE
    Publication number: 20240294551
    Abstract: The present disclosure provides compounds useful for the inhibition of KRAS G12D, G12V, G12A, G12S, G13D, Q61H, Q61L or G12C. The compounds have a general Formula I?: wherein the variables of Formula I? are defined herein. This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, cancer.
    Type: Application
    Filed: March 25, 2024
    Publication date: September 5, 2024
    Applicant: AMGEN INC.
    Inventors: Ryan Paul Wurz, Yunxiao LI, Primali Vasundera NAVARATNE, Jose M. MEDINA, Ning CHEN, Liping PETTUS, Xiaofen LI, John STELLWAGEN, Kexue LI, Brian Alan LANMAN, Michael M. YAMANO, Wei ZHAO, Benjamin WIGMAN, Fabien EMMETIERE, Albert K. AMEGADZIE, Christopher P. MOHR, Aaron C. SIEGMUND, Rene RAHIMOFF, Zhichen WU, Adriano BAUER, Andrew SMALIGO, Quentin Tercenio, Qingyian Liu, Shon K. Booker