Patents by Inventor Adrianus Fredrik Maarten ALTELAAR

Adrianus Fredrik Maarten ALTELAAR has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for monitoring kinase activity in a sample
    Patent number: 11624082
    Abstract: The present invention relates to a method for monitoring kinase activity or activation in a sample, the method comprises the steps of a) providing a sample comprising a kinase, b) incubating the sample with a protease to cleave the kinase provided in step a) into protease specific proteolytic peptides, c) applying phosphopeptide enrichment to the sample, d) analysing the sample obtained in step c) via liquid chromatography-mass spectrometry, and e) detecting phosphorylations of the kinase provided in step a), wherein the detection of step e) is performed only in case a proteolytic peptide associated with the activation region of the kinase is identified.
    Type: Grant
    Filed: June 21, 2019
    Date of Patent: April 11, 2023
    Assignee: UNIVERSITEIT UTRECHT HOLDING B.V.
    Inventors: Adrianus Fredrik Maarten Altelaar, Thierry Thomas Schmidlin
  • METHOD FOR MONITORING KINASE ACTIVITY IN A SAMPLE
    Publication number: 20210262007
    Abstract: The present invention relates to a method for monitoring kinase activity or activation in a sample, the method comprises the steps of a) providing a sample comprising a kinase, b) incubating the sample with a protease to cleave the kinase provided in step a) into protease specific proteolytic peptides, c) applying phosphopeptide enrichment to the sample, d) analysing the sample obtained in step c) via liquid chromatography-mass spectrometry, and e) detecting phosphorylations of the kinase provided in step a), wherein the detection of step e) is performed only in case a proteolytic peptide associated with the activation region of the kinase is identified.
    Type: Application
    Filed: June 21, 2019
    Publication date: August 26, 2021
    Inventors: Adrianus Fredrik Maarten ALTELAAR, Thierry Thomas SCHMIDLIN