Patents by Inventor Adrianus Johannes Groot

Adrianus Johannes Groot has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SELECTIVE PRESENILIN-2 GAMMA-SECRETASE INHIBITORS
    Publication number: 20210196681
    Abstract: The present invention relates to selective presenilin-2 ?-secretase inhibitors for use in the treatment of various diseases associated with a defect leading to Notch receptor hyperactivity. In particular the present invention relates to selective presenilin-2 ?-secretase inhibitors for use as a highly selective anti-cancer treatment. Preferred selective presenilin-2 ?-secretase inhibitors include small molecules, like 4-aminoquinolines or imidazole compounds, (monoclonal) antibodies and known ?-secretase inhibitors or analogues and combinations thereof.
    Type: Application
    Filed: August 27, 2019
    Publication date: July 1, 2021
    Inventors: Marc Antoine Gijbert Gilles Vooijs, Adrianus Johannes Groot, Jeffrey Bruce Smaill, Patrick David O'Connor, Amir Ashoorzadeh
  • AMINO ACID SEQUENCES DIRECTED AGAINST INTEGRINS AND USES THEREOF
    Publication number: 20110294982
    Abstract: The present invention relates to amino acid sequences that are directed against (as defined herein) Integrins, as well as to compounds or constructs, and in particular proteins and polypeptides, that comprise or essentially consist of one or more such amino acid sequences (also referred to herein as ?amino acid sequences of the invention? com?pounds of the invention?, poly?peptides of the invention?, respectively).
    Type: Application
    Filed: May 11, 2009
    Publication date: December 1, 2011
    Applicant: Ablynx N.V.
    Inventors: Peter Vanlandschoot, Michael John Scott Saunders, Johannes Joseph Wilhelmus De Haard, Christophe Blanchetot, Theo Verrips, Marc Antoine Gijsbert Gilles Vooijs, Adrianus Johannes Groot, Mohamed El Khattabi