Patents by Inventor Adrianus Johannes van den Brule

Adrianus Johannes van den Brule has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Human Papilloma Virus detection in a nucleic acid amplification process using general primers
    Patent number: 6352825
    Abstract: The oligonucleotides: (i) the 23-mer 5′-TTTGTTACTGTGGTAGATACTAC-3′ (SEQ ID NO: 1) or the 23-mer which is complementary to it; (ii) a 23-mer derived from (i) by from 1 to 5 nucleotide substitutions; (iii) a 23+-mer having a 3′ terminal sequence consisting of (i) or (ii); (iv) a fragment of (i) or (ii) having a length of from 8 to 18 nucleotides; (v) the 25-mer 5′-GAAAAATAAACTGTAAATCATATTC-3′ (SEQ ID NO: 2) or the 25-mer which is complementary to it; (vi) a 25-mer derived from (v) by from 1 to 5 nucleotide substitutions; (vii) a 25+-mer having a 3′ terminal sequence consisting of (v) or (vi); (viii) the 28-mer 5′-GAAAAATAAACTGTAAATCATATTCTTC-3′ (SEQ ID NO: 10) or the 28-mer which is complementary to it; (ix) the 28-mer 5′-GAAAAATAAACTGTAAATCATATTCCTC-3′ (SEQ ID NO: 18) or the 28-mer which is complementary to it; (x) a 28-mer derived from (viii) or (ix) by from 1 to 5 nucleotide substitutions; (xi) a 28+-mer having a 3′ terminal seq
    Type: Grant
    Filed: November 25, 1996
    Date of Patent: March 5, 2002
    Assignee: Stichting Researchfonds Pathologie
    Inventors: Christophorus Joannes Meijer, Adrianus Johannes van den Brule, Jan Marcus Walboomers, Petrus Josephus Snijders