Abstract: A cash drawer includes a housing, a drawer slidably mounted in the housing, and an interface module for communicating with a point of sale (POS) system in a selected communications protocol, such as printer driven, standard serial, multi-serial or USB. The module may be conveniently replaced to adapt the cash drawer to a different communication protocol. A sensor senses the open position of the drawer. In multiple cash drawer embodiments, a unique identity associated with each drawer is communicated to the interface module such that any open drawer in the plurality of cash drawers can be uniquely identified. Related methods are also disclosed.