Patents by Inventor Adrienne Kovacsne-Mezei

Adrienne Kovacsne-Mezei has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Levalbuterol hydrochloride polymorph B
    Patent number: 7488758
    Abstract: The invention is directed to levalbuterol HCl Form B and methods of making the same.
    Type: Grant
    Filed: May 20, 2005
    Date of Patent: February 10, 2009
    Assignee: Teva Pharmaceutical Fine Chemicals, S.r.l.
    Inventors: Valeriano Merli, Silvia Mantovani, Stefano Bianchi, Paola Daverio, Angelo Spreafico, Judith Aronhime, Adrienne Kovacsne-Mezei
  • Polymorphs of Dolasetron base and process for preparation thereof
    Publication number: 20090030207
    Abstract: The present invention provides polymorphic forms of dolasetron base and methods for their use and preparation.
    Type: Application
    Filed: July 21, 2008
    Publication date: January 29, 2009
    Inventors: Janos Hajko, Tivadar Tamas, Adrienne Kovacsne-Mezei, Piroska Kovacs
  • Polymorphs of atomoxetine hydrochloride
    Patent number: 7473804
    Abstract: The present invention provides novel crystalline polymorph forms of atomoxetine hydrochloride denominated Forms B and C and methods for their preparation, as well as methods for the preparation of Form A. The present invention provides pharmaceutical compositions that comprise atomoxetine hydrochloride Form B, Form C, or mixtures thereof that can be used to treat attention deficit/hyperactivity disorder.
    Type: Grant
    Filed: July 21, 2005
    Date of Patent: January 6, 2009
    Assignee: Teva Pharmaceutical Fine Chemicals s.r.l.
    Inventors: Judith Aronhime, Stefano Bianchi, Eugenio Castelli, Paola Daverio, Silvia Mantovani, Adrienne Kovacsne-Mezei
  • Polymorphs of atomoxetine hydrochloride
    Publication number: 20080312471
    Abstract: The present invention provides novel crystalline polymorph forms of atomoxetine hydrochloride denominated Forms B and C and methods for their preparation, as well as methods for the preparation of Form A. The present invention provides pharmaceutical compositions that comprise atomoxetine hydrochloride Form B, Form C, or mixtures thereof that can be used to treat attention deficit/hyperactivity disorder.
    Type: Application
    Filed: August 11, 2008
    Publication date: December 18, 2008
    Inventors: Judith Aronhime, Stefano Bianchi, Eugenio Castelli, Paola Daverio, Silvia Mantovani, Adrienne Kovacsne-Mezei
  • Levalbuterol hydrochloride Polymorph A
    Patent number: 7465831
    Abstract: The invention is directed to processes for making levalbuterol HCl Polymorph A from by suspending or forming a first slurry of (R)-SLB(D)-DBTA in at least a first organic solvent, adding HCl to the suspension or slurry of the solid (R)-SLB.D-DBTA until the (R)-SLB.D-DBTA forms levalbuterol HCl Polymorph A, and isolating the levalbuterol HCl Polymorph A.
    Type: Grant
    Filed: July 11, 2007
    Date of Patent: December 16, 2008
    Assignee: Teva Pharmaceutical Fine Chemicals s.r.l.
    Inventors: Valeriano Merli, Silvia Mantovani, Stefano Bianchi, Paola Daverio, Angelo Spreafico, Judith Aronhime, Adrienne Kovacsne-Mezei
  • Polymorphs of memantine hydrochloride
    Patent number: 7462743
    Abstract: A crystalline Form II of memantine hydrochloride, pharmaceutical compositions containing crystalline Form II, and methods of preparing crystalline Forms I and II of memantine hydrochloride are provided.
    Type: Grant
    Filed: January 11, 2006
    Date of Patent: December 9, 2008
    Assignee: Teva Pharmaceutical Fine Chemicals S.r.l.
    Inventors: Valeriano Merli, Paola Daverio, Adrienne Kovacsne-Mezei, Judith Aronhime
  • Processes for the preparation of atomoxetine hydrochloride
    Patent number: 7439399
    Abstract: The present invention provides improved processes for the preparation of atomoxetine hydrochloride under reaction conditions that improve reaction yields and facilitate commercial synthesis. In particular, the invention is directed to the synthesis of atomoxetine HCl by adding HCl to a mixture of (R)-(?)-tomoxetine (S)-(+)-mandelate with an organic solvent, with or without a base and water. In preferred embodiments, the atomoxetine hydrochloride produced is Form A.
    Type: Grant
    Filed: September 7, 2005
    Date of Patent: October 21, 2008
    Assignee: Teva Pharmaceutical Fine Chemicals
    Inventors: Judith Aronhime, Stefano Bianchi, Eugenio Castelli, Paola Daverio, Silvia Mantovani, Adrienne Kovacsne-Mezei
  • Ascomycin crystalline forms and preparation thereof
    Patent number: 7439252
    Abstract: The present invention provides novel crystalline forms of ascomycin as well as processes for the preparation thereof and pharmaceutical compositions comprising such crystalline forms of ascomycin.
    Type: Grant
    Filed: December 1, 2005
    Date of Patent: October 21, 2008
    Assignee: TEVA Gyógyszergyár Zártkörúen Müködö Részvénytársaság
    Inventors: Vilmos Keri, Judith Aronhime, Erzsebet Meszaros Sos, Adrienne Kovacsne-Mezei
  • Crystalline mycophenolate sodium
    Patent number: 7439373
    Abstract: Provided are crystalline mycophenolate sodium forms and processes for their preparation.
    Type: Grant
    Filed: July 20, 2005
    Date of Patent: October 21, 2008
    Assignee: TEVA Gyógyszergyár Zártkörúen Múködö Részvénytársaság
    Inventors: Sandor Molnar, Csaba Szabo, Tivadar Tamas, Janos Hajko, Adrienne Kovacsne-Mezei, Judith Aronhime
  • Processes for preparation of crystalline mycophenolate sodium
    Publication number: 20080103317
    Abstract: Provided are crystalline mycophenolate sodium forms and processes for their preparation.
    Type: Application
    Filed: December 14, 2007
    Publication date: May 1, 2008
    Inventors: Sandor Molnar, Csaba Szabo, Tivadar Tamas, Janos Hajko, Adrienne Kovacsne-Mezei, Judith Aronhime
  • Processes for preparation of crystalline mycophenolate sodium
    Publication number: 20080097096
    Abstract: Provided are crystalline mycophenolate sodium forms and processes for their preparation.
    Type: Application
    Filed: December 14, 2007
    Publication date: April 24, 2008
    Inventors: Sandor Molnar, Csaba Szabo, Tivadar Tamas, Janos Hajko, Adrienne Kovacsne-Mezei, Judith Aronhime
  • Levalbuterol hydrochloride Polymorph A
    Publication number: 20080021244
    Abstract: The invention is directed to processes for making levalbuterol HCl Polymorph A from by suspending or forming a first slurry of (R)-SLB(D)-DBTA in at least a first organic solvent, adding HCl to the suspension or slurry of the solid (R)-SLB.D-DBTA until the (R)-SLB.D-DBTA forms levalbuterol HCl Polymorph A, and isolating the levalbuterol HCl Polymorph A.
    Type: Application
    Filed: July 11, 2007
    Publication date: January 24, 2008
    Inventors: Valeriano Merli, Silvia Mantovani, Stefano Bianchi, Paola Daverio, Angelo Spreafico, Judith Aronhime, Adrienne Kovacsne-Mezei
  • Crystalline forms of dolasetron base and processes for preparation thereof
    Publication number: 20070203176
    Abstract: The present invention provides crystalline polymorphic forms of Dolasetron base. Also provided are methods of preparing the crystalline polymorphic forms of Dolasetron base.
    Type: Application
    Filed: January 5, 2007
    Publication date: August 30, 2007
    Inventors: Janos Hajko, Tivadar Tamas, Adrienne Kovacsne-Mezei, Erika Molnarne
  • Forms of dolasetron mesylate and processes for their preparation
    Publication number: 20070203177
    Abstract: The present invention provides crystalline polymorphic forms of Dolasetron mesylate. Also provided are methods of preparing the crystalline polymorphic forms of Dolasetron mesylate. Further, the crystalline Dolasetron mesylate forms may be used in pharmaceutical compositions.
    Type: Application
    Filed: January 5, 2007
    Publication date: August 30, 2007
    Inventors: Janos Hajko, Tivadar Tamas, Adrienne Kovacsne-Mezei, Erika Molnarne, Csaba Peto, Csaba Szabo
  • Production of dolasetron
    Publication number: 20070203219
    Abstract: The present invention provides an improved process for the preparation of Dolasetron salts, in particularly Dolasetron mesylate. Also provided are intermediates for the process and methods of preparing the intermediates.
    Type: Application
    Filed: January 5, 2007
    Publication date: August 30, 2007
    Inventors: Janos Hajko, Tivadar Tamas, Adrienne Kovacsne-Mezei, Erika Molnarne, Csaba Peto, Csaba Szabo
  • Productioin of dolasetron
    Publication number: 20070203175
    Abstract: The present invention provides an improved process for the preparation of Dolasetron salts, in particularly Dolasetron mesylate. Also provided are intermediates for the process and methods of preparing the intermediates. Intermediates for preparing Dolasetron according to the invention include 7-alkoxycarbonyl-9-(alkoxycarbonylmethyl)-3-trialkylsilyloxy-9-azabicyclo[3.3.1]nonane compounds (SAN compounds) and endo-9-alkoxycarbonyl-5-trialkylsilyloxy-8-azatricyclo[5.3.1.03,8]undecan-10-one compounds (SQO compounds).
    Type: Application
    Filed: January 5, 2007
    Publication date: August 30, 2007
    Inventors: Janos Hajko, Tivadar Tamas, Adrienne Kovacsne-Mezei, Erika Molnarne, Csaba Peto, Csaba Szabo
  • Stable pharmaceutical compositions of desloratadine and processes for preparation of polymorphic forms of desloratadine
    Publication number: 20060223841
    Abstract: Provided are stable pharmaceutical compositions of desloratadine.
    Type: Application
    Filed: June 5, 2006
    Publication date: October 5, 2006
    Inventors: Zoltan Toth, Piroska Kovacs, Csaba Peto, Adrienne Kovacsne-Mezei
  • Polymorphs of memantine hydrochloride
    Publication number: 20060217573
    Abstract: A crystalline Form II of memantine hydrochloride, pharmaceutical compositions containing crystalline Form II, and methods of preparing crystalline Forms I and II of memantine hydrochloride are provided.
    Type: Application
    Filed: January 11, 2006
    Publication date: September 28, 2006
    Inventors: Valeriano Merli, Paola Daverio, Adrienne Kovacsne-Mezei, Judith Aronhime
  • Processes for the preparation of atomoxetine hydrochloride
    Publication number: 20060211772
    Abstract: The present invention provides improved processes for the preparation of atomoxetine hydrochloride under reaction conditions that improve reaction yields and facilitate commercial synthesis. In particular, the invention is directed to the synthesis of atomoxetine HCl by adding HCl to a mixture of (R)-(?)-tomoxetine (S)-(+)-mandelate with an organic solvent, with or without a base and water. In preferred embodiments, the atomoxetine hydrochloride produced is Form A.
    Type: Application
    Filed: September 7, 2005
    Publication date: September 21, 2006
    Inventors: Judith Aronhime, Stefano Bianchi, Eugenio Castelli, Paola Daverio, Silvia Mantovani, Adrienne Kovacsne-Mezei
  • Methods of making pravastatin sodium
    Publication number: 20060194984
    Abstract: The invention encompasses a new crystalline form of pravastatin sodium characterized by X-ray powder diffraction peaks at 3.3, 3.9, 5.4, 6.4, 16.8, and 17.5 degrees two-theta, ±0.1 degrees two-theta and to methods of forming the crystalline form of the present invention and methods of making pravastatin Form B and Form D.
    Type: Application
    Filed: February 9, 2006
    Publication date: August 31, 2006
    Inventors: Vilmos Keri, Edit Nagyne Arvai, Zoltan Czovek, Adrienne Kovacsne-Mezei, Istvan Katai, Csilla Nemethne Racz