Patents by Inventor Adrienne Sue Gordon

Adrienne Sue Gordon has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Detection of cellular exposure to ethanol
    Patent number: 6255057
    Abstract: The present invention relates to determinable effects of ethanol exposure on the cellular localization and abundance of specific proteins, referred to herein as ethanol indicative proteins. More specifically, the present invention is based, in part, on the discovery that the catalytic C&agr; subunit of cAMP dependent protein kinase (PKA), which is normally localized in the Golgi apparatus area, appears to translocate to the nucleus upon exposure of a cell to ethanol. The present invention is further based on the observation that the &dgr;-subunit of PKC translocates from the Golgi area to the perinucleus and the nucleus in response to ethanol exposure, while the &egr;-subunit of PKC migrates from the perinucleus into the cytoplasm. The present invention further relates to the discovery that the detectable amount of the regulatory subunit RI of PKA decreases, while the detectable amount of &agr;PKC, &dgr;PKC and &egr;PKC increases upon exposure of a cell to ethanol.
    Type: Grant
    Filed: July 26, 1996
    Date of Patent: July 3, 2001
    Assignee: Ernest Gallo Clinic and Research Center
    Inventors: Adrienne Sue Gordon, Ivan Diamond, Doug Paul Dohrman