Publication number: 20100104551
Abstract: A composition of a long-acting enzyme comprises the enzyme in a formulation comprising a buffer and an additive selected from the group consisting of tranexamic acid, ?-aminocaproic acid, and analogs of L-lysine other than tranexamic acid and ?-aminocaproic acid, combinations thereof, and mixtures thereof. The composition can further comprise another additive selected from the group consisting of L-lysine, L-arginine, L-ornithine (or its pharmaceutically acceptable salts; e.g., L-ornithine hydrochloride), ?-aminobutyric acid, 5-aminovaleric acid, 7-aminoheptanoic acid, glycylglycine, triglycine, N-?-acetyl-L-arginine, betaine, sarcosine, gelatin, HSA, streptokinase, tPA, uPA, non-ionic surfactants, glycerin, D-sorbitol, combinations thereof, and mixtures thereof. A method for prolonging the activity of an autodegradable enzyme comprises storing the enzyme after manufacture at a low pH, and reconstituting the acidified enzyme before use with a solution containing at least one of such additives.
Type:
Application
Filed:
October 22, 2009
Publication date:
April 29, 2010
Applicant:
Talecris Biotherapeutics, Inc.
Inventors:
Dharmendra M. Jani, Kai Kwok, Gregory L. McIntire, Bruce A. Pfeffer, Afshin Shafiee, Ruiwen Shi, Srini Venkatesh, Hongna Wang, Yan Huang, Stephen R. Davio
Publication number: 20070134231
Abstract: A composition of a long-acting enzyme comprises the enzyme in a formulation comprising a buffer and an additive selected from the group consisting of tranexamic acid, ?-aminocaproic acid, and analogs of L-lysine other than tranexamic acid and ?-aminocaproic acid, combinations thereof, and mixtures thereof. The composition can further comprise another additive selected from the group consisting of L-lysine, L-arginine, L-ornithine (or its pharmaceutically acceptable salts; e.g., L-ornithine hydrochloride), ?-aminobutyric acid, 5-aminovaleric acid, 7-aminoheptanoic acid, glycylglycine, triglycine, N-?-acetyl-L-arginine, betaine, sarcosine, gelatin, HSA, streptokinase, tPA, uPA, non-ionic surfactants, glycerin, D-sorbitol, combinations thereof, and mixtures thereof. A method for prolonging the activity of an autodegradable enzyme comprises storing the enzyme after manufacture at a low pH, and reconstituting the acidified enzyme before use with a solution containing at least one of such additives.
Type:
Application
Filed:
November 17, 2006
Publication date:
June 14, 2007
Inventors:
Dharmendra Jani, Kai Kwok, Gregory McIntire, Bruce Pfeffer, Afshin Shafiee, Ruiwen Shi, Srini Venkatesh, Hongna Wang, Yan Huang, Stephen Davio