Abstract: Various endovascular scaffolds and methods of making and using the endovascular scaffolds are disclosed. In one variation, an endovascular scaffold is disclosed comprising a plurality of undulating rings and a plurality of interconnecting struts connecting the plurality of undulating rings to one another. The plurality of undulating rings can be radially compressible into a delivery configuration and expandable from the delivery configuration to an expanded configuration when deployed. At least some of the interconnecting struts can biodegrade after the endovascular scaffold is deployed within the peripheral vessel.

Abstract: The present invention provides a method for the treatment of retinoblastoma comprising administering a composition comprising a therapeutically active agent to a subject in need thereof by injection of the composition into the vitreous cavity, suprachoroidal space, supraciliary space or sub-Tenon's space of the eye adjacent to a retinoblastoma tumour. The invention also provides a composition comprising at least one therapeutically active agent selected from the group consisting of a Bcl-2 inhibitor or a topoisomerase inhibitor for use in the treatment of retinoblastoma, wherein the composition is for administration into the vitreous cavity, suprachoroidal space, sub-Tenon's space, or supraciliary space adjacent to a retinoblastoma tumour in an eye. Also provided is a kit comprising a Bcl-2 inhibitor and a topoisomerase inhibitor for use in the treatment of retinoblastoma, wherein the Bcl-2 inhibitor and the topoisomerase inhibitor are for separate, simultaneous or sequential administration.