Patents by Inventor Aftab S. Karim

Aftab S. Karim has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antibodies and Antigen Binding Fragments Against CD155 Methods of Use Thereof
    Publication number: 20220056146
    Abstract: A humanized antibody or antigen binding fragment that binds to the poliovirus receptor (PVR) can be utilized in the preparation of antibody drug conjugates (ADCs) to target nucleic acids, peptides and proteins, drugs and radiopharmaceuticals to cancer cells. These antibodies or antigen binding fragments can also be used for checkpoint blockade where binding to PVR (CD 155) blocks the PVR from binding TIGIT. The humanized antibodies can be used either alone or in combination with other checkpoint inhibitors known in the art. The humanized antibody or antigen binding fragment of this invention can also modulate the PVR-DNAM-1 axis in order to upregulate DNAM 1 (CD 226) expression on T cells or NK cells, thereby helping to restore immunosurveillance mechanisms. The antibody or antigen binding fragment that bind to PVR can also be incorporated in CAR-T cells or CAR NK cells.
    Type: Application
    Filed: August 20, 2021
    Publication date: February 24, 2022
    Inventors: Aftab S. Karim, Robert Holgate, Arron Hearn
  • Antibodies and antibody fragments against the CD155 receptor and methods of use thereof
    Patent number: 11098130
    Abstract: A humanized antibody to the poliovirus receptor can be used to target nucleic acids, proteins, and chemicals to brain cancer cells, thus providing treatment for tumors that are otherwise hard to treat due to the difficulty of getting treatments through the blood brain barrier.
    Type: Grant
    Filed: March 26, 2019
    Date of Patent: August 24, 2021
    Assignee: Tasrif Pharmaceutical, LLC
    Inventors: Aftab S. Karim, Robert Holgate, Arron Hearn
  • Reverse Transcriptase Dependent Conversion of RNA Templates Into DNA
    Publication number: 20190374567
    Abstract: The function of reverse transcriptase can be utilized to convert synthetic RNA templates into double stranded DNA for including but not limited to therapeutic function; to aid in diagnosis; to clear infection in latent cell populations such as memory T-cells; and prevent infection in exposed individuals by delivery of the RNA templates/primers to cell populations prone to infection, such as CD4 T-cells.
    Type: Application
    Filed: September 24, 2018
    Publication date: December 12, 2019
    Inventor: Aftab S. Karim
  • Method and Apparatus for Cutting Embolic Coils
    Publication number: 20140128906
    Abstract: The invention relates to a hand held microsurgical apparatus for cutting metallic embolic coils and the methods pertaining thereto.
    Type: Application
    Filed: January 10, 2014
    Publication date: May 8, 2014
    Applicant: Neurosurj Research & Development, LLC
    Inventor: Aftab S. Karim
  • METHOD AND APPARATUS FOR CUTTING EMBOLIC COILS
    Publication number: 20130211442
    Abstract: The invention relates to a hand held microsurgical apparatus for cutting metallic embolic coils and the methods pertaining thereto.
    Type: Application
    Filed: January 7, 2011
    Publication date: August 15, 2013
    Applicant: Neurosurj Research & Development, LLC
    Inventor: Aftab S. Karim
  • SUBLAMINAR WIRED SCREWED DEVICE FOR SPINAL FUSION
    Publication number: 20110245875
    Abstract: The invention relates to an anchoring device to be used for stabilizing the spine and the methods pertaining thereto.
    Type: Application
    Filed: April 5, 2010
    Publication date: October 6, 2011
    Inventor: Aftab S. Karim
  • Inhibition of expression of interleukin-5
    Patent number: 6048726
    Abstract: A method of inhibiting interleukin-5 expression using an antisense oligonucleotide which contains at least one non-natural internucleoside linkage.
    Type: Grant
    Filed: May 15, 1998
    Date of Patent: April 11, 2000
    Inventors: Joel K. Weltman, Aftab S. Karim