Patents by Inventor Afzal Khan

Afzal Khan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • USE OF 7-AZAINDOLES IN THE INHIBITION OF C-JUN N-TERMINAL KINASE
    Publication number: 20100069358
    Abstract: The present invention provides a compound of formula (I); or a pharmaceutically acceptable salt thereof in the inhibition of c-Jun N-terminal kinase (JNK) activity and particularly in the treatment of neurodegenerative disorders, inflammatory diseases and/or and autoimmune diseases. The invention also provides processes for the manufacture of said compounds of formula (I) or a pharmaceutically acceptable salt thereof and compositions containing them.
    Type: Application
    Filed: August 5, 2009
    Publication date: March 18, 2010
    Applicant: Eisai R&D Management Co., Ltd.
    Inventors: Piotr Pawel GRACZYK, Paschalis DIMOPOULOS, Christopher Neil FARTHING, Gurpreet Singh BHATIA, Afzal KHAN
  • INHIBITORS OF C-JUN N-TERMINAL KINASES FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS RELATING TO APOPTOSIS AND/OR INFLAMMATION
    Publication number: 20100035878
    Abstract: The present invention provides novel compounds of formula I and their use in the inhibition of c-Jun N-terminal kinases. The present invention further provides the use of these compounds in medicine, in particular in the prevention and/or treatment of neurodegenerative disorders related to apoptosis and/or inflammation.
    Type: Application
    Filed: October 6, 2009
    Publication date: February 11, 2010
    Applicant: EISAI R & D MANAGEMENT CO., LTD.
    Inventors: Afzal KHAN, Darren Peter MEDLAND, Gurpreet BHATIA
  • Synthesis of 5 substituted 7-azaindoles and 7-azaindolines
    Patent number: 7652137
    Abstract: The present invention provides a novel substituted azaindoline intermediate of formula (I) and a method for its synthesis. The novel substitued azaindoline intermediate (I) is provided for use in the manufacture of 5-substituted 7-azaindolines and 5-substituted 7-azaindoles.
    Type: Grant
    Filed: March 5, 2004
    Date of Patent: January 26, 2010
    Assignee: Eisai R & D Management Co., Ltd.
    Inventors: Piotr Pawel Graczyk, Afzal Khan, Gurpreet Singh Bhatia
  • Inhibitors of c-Jun N-terminal kinases for the treatment of neurodegenerative disorders relating to apoptosis and/or inflammation
    Patent number: 7645769
    Abstract: The present invention provides novel compounds of formula I and their use in the inhibition of c-Jun N-terminal kinases. The present invention further provides the use of these compounds in medicine, in particular in the prevention and/or treatment of neurodegenerative disorders related to apoptosis and/or inflammation.
    Type: Grant
    Filed: August 4, 2006
    Date of Patent: January 12, 2010
    Assignee: Eisai R & D Management Co., Ltd.
    Inventors: Afzal Khan, Darren Peter Medland, Gurpreet Singh Bhatia
  • JNK inhibitors
    Patent number: 7612086
    Abstract: The present invention provides novel compounds of formula (I) and their use in the inhibition of c-Jun N-terminal kinases. The present invention further provides the use of these compounds in medicine, in particular in the prevention and/or treatment of neurodegenerative disorders related to apoptosis and/or inflammation.
    Type: Grant
    Filed: May 14, 2004
    Date of Patent: November 3, 2009
    Assignee: Eisai R & D Management Co. Ltd.
    Inventors: Piotr Graczyk, Vanessa Palmer, Afzal Khan
  • JNK INHIBITORS
    Publication number: 20090215771
    Abstract: The present invention provides novel compounds of formula I and their use in the inhibition of c-Jun N-terminal kinases. The present invention further provides the use of these compounds in medicine, in particular in the prevention and/or treatment of neurodegenerative disorders related to apoptosis and/or inflammation.
    Type: Application
    Filed: June 20, 2008
    Publication date: August 27, 2009
    Inventors: Piotr GRACZYK, Afzal KHAN, Gurpreet BHATIA, Yoichi IIMURA
  • FUSED AMINODIHYDROTHIAZINE DERIVATIVES
    Publication number: 20090209755
    Abstract: A compound represented by the general formula: or a pharmaceutically acceptable salt thereof or a solvate thereof, wherein Ring A is a C6-14 aryl group or the like, L is —NReCO— or the like (wherein Re is a hydrogen atom or the like), Ring B is a C6-14 aryl group or the like, X is a C1-3 alkylene group or the like, Y is a single bond or the like, Z is a C1-3 alkylene group or the like, R1 and R2 are each independently a hydrogen atom or the like, and R3, R4, R5 and R6 are independently a hydrogen atom, a halogen atom or the like, has an A? production inhibitory effect or a BACE1 inhibitory effect and is useful as a prophylactic or therapeutic agent for a neurodegenerative disease caused by A? and typified by Alzheimer-type dementia.
    Type: Application
    Filed: January 16, 2009
    Publication date: August 20, 2009
    Inventors: Yuichi SUZUKI, Takafumi MOTOKI, Toshihiko KANEKO, Mamoru TAKAISHI, Tasuku ISHIDA, Yoichi KITA, Kunitoshi TAKEDA, Noboru YAMAMOTO, Afzal KHAN, Paschalis DIMOPOULOS
  • 7-azaindoles as inhibitors of c-Jun N-terminal kinases for the treatment of neurodegenerative disorders
    Patent number: 7534800
    Abstract: The present invention relates to novel 3,5-substituted 7-azaindole compounds of formula (I), their use in the inhibition of c-Jun N-terminal kinases, their use in medecine and particularly in the prevention and/or treatment of neurodegenerative disorders related to apoptosis and/or inflammation. The invention also provides processes for manufacture of said compounds, compositions containing them and processes for manufacturing such compositions.
    Type: Grant
    Filed: March 17, 2003
    Date of Patent: May 19, 2009
    Assignee: Eisai R & D Development Co., Ltd.
    Inventors: Piotr Graczyk, Hirotoshi Numata, Afzal Khan, Vanessa Palmer
  • JNK inhibitors
    Patent number: 7432375
    Abstract: The present invention provides novel compounds of formula (I) and their use in the inhibition of c-Jun N-terminal kinases. The present invention further provides the use of these compounds in medicine, in particular in the prevention and/or treatment of neurodegenerative disorders related to apoptosis and/or inflammation.
    Type: Grant
    Filed: March 5, 2004
    Date of Patent: October 7, 2008
    Assignee: Eisai R & D Management Co., Ltd.
    Inventors: Piotr Graczyk, Afzal Khan, Gurpreet Bhatia, Yoichi Iimura
  • Jun kinase inhibitors
    Patent number: 7314940
    Abstract: The present invention provides novel compounds of formula I and their use in the inhibition of c-Jun N-terminal kinases. The present invention further provides the use of these compounds in medicine, in particular in the prevention and/or treatment of neurodegenerative disorders related to apoptosis and/or inflammation.
    Type: Grant
    Filed: April 4, 2002
    Date of Patent: January 1, 2008
    Assignee: Eisai Co., Ltd.
    Inventors: Piotr Graczyk, Hirotoshi Numata, Afzal Khan, Vanessa Palmer, Darren Peter Medland, Hitoshi Oinuma, Gurpreet Bhatia
  • Jnk inhibitors
    Publication number: 20070142366
    Abstract: The present invention provides novel compounds of formula (I) and their use in the inhibition of c-Jun N-terminal kinases. The present invention further provides the use of these compounds in medicine, in particular in the prevention and/or treatment of neurodegenerative disorders related to apoptosis and/or inflammation.
    Type: Application
    Filed: May 14, 2004
    Publication date: June 21, 2007
    Applicant: Eisai Co., Ltd.
    Inventors: Piotr Graczyk, Vanessa Palmer, Afzal Khan
  • Inhibitors of c-Jun N-terminal kinases for the treatment of neurodegenerative disorders relating to apoptosis and/or inflammation
    Publication number: 20070072896
    Abstract: The present invention provides novel compounds of formula I and their use in the inhibition of c-Jun N-terminal kinases. The present invention further provides the use of these compounds in medicine, in particular in the prevention and/or treatment of neurodegenerative disorders related to apoptosis and/or inflammation.
    Type: Application
    Filed: August 4, 2006
    Publication date: March 29, 2007
    Applicant: Eisai Co., Ltd.
    Inventors: Afzal Khan, Darren Medland, Gurpreet Bhatia
  • Synthesis
    Publication number: 20060235042
    Abstract: The present invention provides a novel substituted azaindoline intermediate of formula (I) and a method for its synthesis. The novel substitued azaindoline intermediate (I) is provided for use in the manufacture of 5-substituted 7-azaindolines and 5-substituted 7-azaindoles.
    Type: Application
    Filed: March 5, 2004
    Publication date: October 19, 2006
    Applicant: Eisai Co., Ltd.
    Inventors: Piotr Graczyk, Afzal Khan, Gurpreet Bhatia
  • 7-azaindoles as inhibitors of c-jun n-terminal kinases for the treatment of neurodegenerative disorders
    Publication number: 20050272761
    Abstract: The present invention relates to novel 3,5-substituted 7-azaindole compounds of formula (I), their use in the inhibition of c-Jun N-terminal kinases, their use in medecine and particularly in the prevention and/or treatment of neurodegenerative disorders related to apoptosis and/or inflammation. The invention also provides processes for manufacture of said compounds, compositions containing them and processes for manufacturing such compositions.
    Type: Application
    Filed: March 17, 2003
    Publication date: December 8, 2005
    Applicant: Eisai Co., Ltd.
    Inventors: Piotr Graczyk, Hirotoshi Numata, Afzal Khan, Vanessa Palmer
  • Jun kinase inhibitors
    Publication number: 20040235864
    Abstract: The present invention provides novel compounds of formula I 1
    Type: Application
    Filed: April 23, 2004
    Publication date: November 25, 2004
    Inventors: Piotr Graczyk, Hiroshi Numata, Afzal Khan, Vanessa Palmer, Darren Peter Medland, Hitoshi Oinuma, Gurpreet Bhatia
  • Front face of a wheel
    Patent number: D523386
    Type: Grant
    Filed: November 10, 2005
    Date of Patent: June 20, 2006
    Assignee: Kahn Design Ltd.
    Inventor: Afzal Khan
  • Front face of a wheel
    Patent number: D527332
    Type: Grant
    Filed: November 4, 2005
    Date of Patent: August 29, 2006
    Assignee: Kahn Design Ltd.
    Inventor: Afzal Khan
  • Motor vehicle wheel
    Patent number: D460729
    Type: Grant
    Filed: July 11, 2001
    Date of Patent: July 23, 2002
    Assignee: A Kahn Design Limited
    Inventor: Afzal Khan
  • Front face of a wheel
    Patent number: D531951
    Type: Grant
    Filed: November 4, 2005
    Date of Patent: November 14, 2006
    Assignee: Kahn Design Ltd.
    Inventor: Afzal Khan