Abstract: Methods and compositions for inhibiting or preventing the skin irritating or sensitizing effects of a skin irritating or sensitizing component of a dermal or transdermal drug delivery system are disclosed. The composition comprises a mast cell degranulating agent which is capable of inducing a state of immunological tolerance to the skin sensitizing agent by delivery prior to, or at the onset of transdermal drug delivery. Such an agent, preferably cis-urocanic acid or an analogue or metabolite thereof, can be administered before, during or after each transdermal drug delivery to achieve immune tolerance countersensitization. Alternatively, the agent can be used to induce countersensitization. The agent is preferably capable of permeating the epidermis and is administered transdermally. Novel methods and compositions comprising cis-urocanic acid or an analogue or metabolite thereof to obtain anti-inflammatory effects are also disclosed.

Abstract: A device for the controlled release and delivery of a pharmacologically active agent, comprising a vinyl gel layer and a pharmacologically active agent uniformly dispersed in the layer in a pharmacologically effective amount, the vinyl layer comprising a polyvinyl chloride resin, a primary plasticizer for the polyvinyl chloride resin, and an organic, nonvolatile gel forming additive in an amount sufficient to form a gel.

Abstract: A device for the controlled release and delivery of a pharmacologically active agent, comprising a vinyl gel layer and a pharmacologically active agent uniformly dispersed in the layer in a pharmacologically effective amount, the vinyl layer comprising an emulsion polymerized polyvinyl chloride resin, a primary plasticizer for the polyvinyl chloride resin, and an organic, nonvolatile gel forming additive in an amount sufficient to form a gel.

Abstract: Articles of manufacture are disclosed for the controlled delivery of pest controlling substances. Methods for producing such articles and utilizing them in pest control programs are also described. Laminated articles are provided which comprise one or more layers containing active pest control and pest attractant substances and which allow the controlled release of the pest controlling substance from within the laminate to the surface of the laminate so as to maximize efficiency against target species in the surrounding environment. The laminated structure also permits prolonged, controlled release of pest controlling substances and properly timed combinations of such substances that might otherwise be prematurely dissipated, decomposed or inefficiently applied. Various combinations of polymeric materials and active agents and a number of different laminated structures are utilized to optimize efficient use of the pest controlling substance against a variety of target species.

Abstract: Process for controlling cockroaches and other crawling insects comprising deploying strips of polymeric controlled release dispensers to insect crawl paths and harborages, the dispensers containing a low volatility toxicant for the insects which is made available on the surfaces of the dispensers and which, in a concentration of from 50 to 500 mg/sq.ft. of dispenser active surface area, is lethal to the insects after relatively brief periods of direct physical contact. Generally, strips aggregating from about 1/3 to about 3 sq.ft., of active dispenser surface area are adequate to achieve control of cockroaches and other crawling insects in an average size room having a floor area of about 100-150 sq.ft.

Abstract: N-Tetradecyl formate has been found to be effective as a sex pheromone mimic for disrupting the reproductive cycle of insects, especially the Heliothis complex which includes Heliothis zea (corn earworm), Heliothis virescens (tobacco budworm), and Heliothis armigera. The compound and compositions containing the compound n-tetradecyl formate may be applied to crops which are subject to damage by such insects in any suitable manner, for example, in sprays, dusts and powders. Particularly effective compositions comprise polymeric particles or flakes containing n-tetradecyl formate. The particles or flakes may have an adhesive coating so that upon application the particles become attached to the upper leaves, stalks, etc. where the insects tend to be more concentrated.

Abstract: A laminated indicator which changes in a visually perceptible mode with the passage of time and a method for making such an indicator. At least two layers are provided whereby the molecular migration of an agent in an interior layer to the outermost surface of the exterior layer causes a change which can be visually percepted, e.g., a change in color or shade. Preferred embodiments include the migration of a dye or the migration of an acid or base wherein the outermost layer has the other member of an acid-base pair and a pH indicator.

Abstract: A method for the control of agricultural pests such as insects which comprises the application of polymeric particles which release an agent in a controlled manner. The particles can be applied to plants, seeds, soil or to the surface of the soil.

Abstract: The invention concerns solid, polymeric dispensers for insecticides effective in controlling flying insects, especially flies, and to methods for using such strips in controlling such insects.

Abstract: Articles of manufacture are disclosed for the controlled delivery of pest controlling substances. Methods for producing such articles and utilizing them in pest control programs are also described. Laminated articles are provided which comprise one or more layers containing active pest control and pest attractant substances and which allow the controlled release of the pest controlling substance from within the laminate to the surface of the laminate so as to maximize efficiency against target species in the surrounding environment. The laminated structure also permits prolonged, controlled release of pest controlling substances and properly timed combinations of such substances that might otherwise be prematurely dissipated, decomposed or inefficiently applied. Various combinations of polymeric materials and active agents and a number of different laminated structures are utilized to optimize efficient use of the pest controlling substance against a variety of target species.

Abstract: Process for controlling cockroaches and other crawling insects comprising deploying strips of polymeric controlled release dispensers to insect crawl paths and harborages, the dispensers containing a low volatility toxicant for the insects which is made available on the surfaces of the dispensers and which, in a concentration of from 50 to 500 mg/sq.ft. of dispenser active surface area, is lethal to the insects after relatively brief periods of direct physical contact. Generally, strips aggregating from about 1/3 to about 3 sq.ft., of active dispenser surface area are adequate to achieve control of cockroaches and other crawling insects in an average sized room having a floor area of about 100-150 sq.ft.

Abstract: There are disclosed antistatic carpet products and compositions and methods for producing such carpets. Application to carpet backing of polymeric compositions containing migrating antistatic agents, and in certain instances accelerators for such agents, imparts antistatic properties to carpet fibers of natural and synthetic material.