Patents by Inventor Agnès Noel

Agnès Noel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Combination treatment of cancer
    Patent number: 9783615
    Abstract: The present invention provides MT4-MMP inhibitor and EGFR inhibitor for use in the treatment of cancer, wherein said MT4-MMP inhibitor and EGFR inhibitor are different from each other. MT4-MMP (MMP-17) is a glycosylphosphatidyl inositol (GPI) anchored MMP produced by cancer cells that promotes tumor vascularization and metastases. The present invention found that MT4-MMP expression promotes cancer cell proliferation. These effects involve retinoblastoma protein (Rb) inactivation, cyclin dependent kinase CDK4 activation and Epidermal Growth Factor Receptor (EGFR) signaling. Co-immuno-precipitations indicate the existence of protein complexes harboring MT4-MMP and EGFR. The present invention further found a novel mechanism of MT4-MMP action through an outside-in signaling involving EGFR. An unexpected crosstalk between an MMP and EGFR was identified and recognized as a key driver of cancer cell biology.
    Type: Grant
    Filed: September 2, 2013
    Date of Patent: October 10, 2017
    Assignee: UNIVERSITE DE LIEGE
    Inventors: Agnès Noel, Nor Eddine Sounni, Alexandra Paye
  • USE OF CYCLODEXTRIN FOR TREATMENT AND PREVENTION OF BRONCHIAL INFLAMMATORY DISEASES
    Publication number: 20150258133
    Abstract: The invention provides the use of a cyclodextrin compound for the manufacturing of a medicament for the treatment or prevention of bronchial inflammatory diseases, particularly for asthma and chronic obstructive pulmonary disease (COPD).
    Type: Application
    Filed: April 29, 2015
    Publication date: September 17, 2015
    Inventors: Didier Cataldo, Brigitte Evrard, Agnes Noel, Jean-Michel Foldart
  • COMBINATION TREATMENT OF CANCER
    Publication number: 20150232572
    Abstract: The present invention provides MT4-MMP inhibitor and EGFR inhibitor for use in the treatment of cancer, wherein said MT4-MMP inhibitor and EGFR inhibitor are different from each other. MT4-MMP (MMP-17) is a glycosylphosphatidyl inositol (GPI) anchored MMP produced by cancer cells that promotes tumor vascularization and metastases. The present invention found that MT4-MMP expression promotes cancer cell proliferation. These effects involve retinoblastoma protein (Rb) inactivation, cyclin dependent kinase CDK4 activation and Epidermal Growth Factor Receptor (EGFR) signaling. Co-immuno-precipitations indicate the existence of protein complexes harboring MT4-MMP and EGFR. The present invention further found a novel mechanism of MT4-MMP action through an outside-in signaling involving EGFR. An unexpected crosstalk between an MMP and EGFR was identified and recognized as a key driver of cancer cell biology.
    Type: Application
    Filed: September 2, 2013
    Publication date: August 20, 2015
    Applicant: UNIVERSITÉ DE LIÈGE
    Inventors: Agnès Noel, Eddine Nor Sounni, Alexandra Paye
  • Use of cyclodextrin for treatment and prevention of bronchial inflammatory diseases
    Patent number: 9034846
    Abstract: The invention provides the use of a cyclodextrin compound for the manufacturing of a medicament for the treatment or prevention of bronchial inflammatory diseases, particularly for asthma and chronic obstructive pulmonary disease (COPD).
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: May 19, 2015
    Assignee: UNIVERSITE DE LIEGE
    Inventors: Didier Cataldo, Brigitte Evrard, Agnes Noel, Jean-Michel Foldart
  • Use of cyclodextrin for treatment and prevention of bronchial inflammatory diseases
    Publication number: 20120295872
    Abstract: The invention provides the use of a cyclodextrin compound for the manufacturing of a medicament for the treatment or prevention of bronchial inflammatory diseases, particularly for asthma.
    Type: Application
    Filed: May 23, 2012
    Publication date: November 22, 2012
    Applicant: UNIVERSITE DE LIEGE
    Inventors: Didier Cataldo, Brigitte Evrard, Agnés Noel, Jean-Michel Foidart
  • Use of FGF inhibiting substituted 1,2,3 indolizine derivatives in the preparation of medicaments which can be used to treat diseases linked to pathological choroidal angiogenesis
    Patent number: 8034828
    Abstract: The present invention thus relates to the use of 1,2,3-substituted indolizine derivatives in the preparation of medicaments of use in the treatment of diseases related to pathological choroidal angiogenesis, which derivatives correspond to the following general formula (I):
    Type: Grant
    Filed: August 29, 2008
    Date of Patent: October 11, 2011
    Assignee: Sanofi-Aventis
    Inventors: Alain Badorc, Francoise Bono, Marie-Francoise Bordes, Jean-Michel Foidart, Nathalie Guillo, Agnes Noel, Jean-Marie Rakic
  • USE OF CYCLODEXTRIN FOR TREATMENT AND PREVENTION OF BRONCHIAL INFLAMMATORY DISEASES
    Publication number: 20110028432
    Abstract: The invention provides the use of a cyclodextrin compound for the manufacturing of a medicament for the treatment or prevention of bronchial inflammatory diseases, particularly for asthma.
    Type: Application
    Filed: July 29, 2010
    Publication date: February 3, 2011
    Inventors: Didier Cataldo, Brigitte Evrard, Agnès Noel, Jean-Michel Foidart
  • Use of cyclodextrin for treatment and prevention of bronchial inflammatory diseases
    Patent number: 7829550
    Abstract: The invention provides the use of a cyclodextrin compound for the manufacturing of a medicament for the treatment or prevention of bronchial inflammatory diseases, particularly for asthma.
    Type: Grant
    Filed: September 30, 2005
    Date of Patent: November 9, 2010
    Assignee: Universite de Liege
    Inventors: Didier Cataldo, Brigitte Evrard, Agnès Noel, Jean-Michel Foidart
  • USE OF FGF INHIBITING SUBSTITUTED 1,2,3 INDOLIZINE DERIVATIVES IN THE PREPARATION OF MEDICAMENTS WHICH CAN BE USED TO TREAT DISEASES LINKED TO PATHOLOGICAL CHOROIDAL ANGIOGENESIS
    Publication number: 20090030034
    Abstract: The present invention thus relates to the use of 1,2,3-substituted indolizine derivatives in the preparation of medicaments of use in the treatment of diseases related to pathological choroidal angiogenesis, which derivatives correspond to the following general formula (I):
    Type: Application
    Filed: August 29, 2008
    Publication date: January 29, 2009
    Applicant: SANOFI-AVENTIS
    Inventors: Alain BADORC, Francoise BONO, Marie-Francoise BORDES, Jean-Michel FOIDART, Nathalie GUILLO, Agnes NOEL, Jean Marie RAKIC
  • Use of cyclodextrin for treatment and prevention of bronchial inflammatory diseases
    Publication number: 20090012041
    Abstract: The invention provides the use of a cyclodextrin compound for the manufacturing of a medicament for the treatment or prevention of bronchial inflammatory diseases, particularly for asthma.
    Type: Application
    Filed: September 30, 2005
    Publication date: January 8, 2009
    Inventors: Didier Cataldo, Brigitte Evrard, Agnes Noel, Jean-Michel Foidart
  • Mucoadhesive Pharmaceutical Compositions Comprising Chemoattractants
    Publication number: 20080293630
    Abstract: The invention relates to a mucoadhesive pharmaceutical composition comprising a polymer and a chemoattractant wherein the pH of the composition is greater than 6 which is useful in the treatment of a anogenital or oral disease, particularly an anogenital or oral disease cause by the human papillomavirus.
    Type: Application
    Filed: December 12, 2005
    Publication date: November 27, 2008
    Applicant: UNIVERSITE DE LIEGE
    Inventors: Ludivine Herman, Pascale Hubert, Philippe Delvenne, Jacques Boniver, Brigitte Evard, Luc Delattre, Francis Frankenne, Agnes Noel, Jean-Michel Foidart
  • 5-(1,1'Biphenyl)-4-Yl-5-(4-(4-Aminoacylphenyl)-Piperazin)-1-Yl-Pyrimidine-2,4,6,-Trione Derivatives, As Inhibitors Of Zinc Metallondopeptidases, Their Preparation And Use
    Publication number: 20080096897
    Abstract: New Pyrimidinetrione derivatives represented by formula (I), wherein R1 and R2 are defined in the description, composition thereof, and methods of preparation are described. The compounds are useful in the treatment of disease involving metalloproteinases.
    Type: Application
    Filed: August 16, 2005
    Publication date: April 24, 2008
    Inventors: Bernard Pirotte, Stephane Counerotte, Vanessa Detry, Francis Frankenne, Jean-Michel Foidart, Agnes Noel
  • Mucoadhesive composition comprising polyacrylate and chemoattractant
    Publication number: 20060228417
    Abstract: The invention relates to a mucoadhesive pharmaceutical composition comprising an acrylic acid containing polymer and a chemoattractant wherein the pH of the composition is 6 or less.
    Type: Application
    Filed: July 9, 2004
    Publication date: October 12, 2006
    Inventors: Pascale Hubert, Brigitte Evrard, Luc Delattre, Jacques Boniver, Philipe Delvenne, Agnes Noel, Francis Frankenne, Jean-Michel Foidart