Abstract: Provided herein are synthetic analogs of withanolide natural products and their pharmaceutical uses in treating neurodegenerative diseases.

Abstract: Provided herein are synthetic analogs of withanolide natural products and their pharmaceutical uses in treating neurodegenerative diseases.

Abstract: Provided herein are synthetic analogs of withanolide natural products and their pharmaceutical uses in treating neurodegenerative diseases.

Abstract: Provided herein are synthetic analogs of withanolide natural products of formula (I), wherein R1-R4 are as defined herein, and their pharmaceutical uses in treating neurodegenerative diseases.

Abstract: Provided herein are synthetic analogs of withanolide natural products of formula (I), wherein R1-R4 are as defined herein, and their pharmaceutical uses in treating neurodegenerative diseases.

Abstract: The present invention relates to a method of treating non-melanoma skin cancer comprising: (a) intravenously administering a porphyrin based photosensitizer to a subject with non-melanoma skin cancer; (b) irradiating one or more tumors and a circumferential peritumoral margin of at least 1 mm with a light at a wavelength absorbed by said photosensitzer; wherein the irradiating step delivers a light dose of 180 J/cm2. It has been found that the above treatment gives extremely good efficacy while having a surprisingly good cosmetic outcome.

Abstract: A pseudorandom sequence generator including a first feedback shift register having at least one input and at least one output and a first controller having an output in communication with the at least one input of the first feedback shift register; the first feedback shift register operating at a first speed S1 and the first controller operating at a second speed S2. In one embodiment the first speed S1 of the first feedback shift register is an integer multiple of the second speed S2 of the first controller. In another embodiment the first feedback shift register includes a shift register having an input, an output, and at least one tap; and a feedback function generator having a first input in communication with the at least one tap of the shift register, a second input in communication with the output of the first controller, and an output in communication with the input of the shift register; the feedback function generator includes at least one feedback function.

Abstract: Green porphyrins act as antigen-specific immunomodulators in the active phase of an immune response to a particular antigen. This effect occurs at ambient light levels.

Abstract: Green porphyrins act as antigen-specific immunomodulators in the active phase of an immune response to a particular antigen, as well as to interfere with intercellular communication. These effects occur in the absence of radiation absorbed by the green porphyrin.

Abstract: Green porphyrins act as antigen-specific immunomodulators in the active phase of an immune response to a particular antigen. This effect occurs at ambient light levels.