Patents by Inventor Agnes S. Kim-Meade

Agnes S. Kim-Meade has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process and intermediates for the synthesis of 1,2-substituted 3,4-dioxo-1-cyclobutene compounds
    Patent number: 8519168
    Abstract: This application discloses a novel process for the preparation of 1,2-substituted 3,4-dioxo-1-cyclobutene compounds, which have utility, for example, in the treatment of CXC chemokine-mediated diseases, and intermediates useful in the synthesis thereof.
    Type: Grant
    Filed: July 1, 2008
    Date of Patent: August 27, 2013
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Xiaoyong Fu, Frank Bruno Guenter, Agnes S. Kim-Meade, Kenneth Stanley Matthews, Mathew Thomas Maust, Gerald Werne, Jason L. Winters, Jianguo Yin, Shuyi Zhang, David J. Moloznik
  • Synthesis of 2-Hydroxy-N,N-dimethyl-3-[[2-[[1(R)-(5-methyl-2-furanyl)propyl]amino]-3,4-dioxo-1-cyclobuten-1-yl]amino]benzamide
    Patent number: 7910775
    Abstract: Disclosed is a process for making the compound of formula I: using the compounds of formulas II, Q, and XI or XII: wherein A is selected from the group consisting of Br, Cl and I (with Br being preferred); and R represents (C1-C10)alkyl. Also disclosed are intermediate compounds that are made in the disclosed process.
    Type: Grant
    Filed: October 17, 2008
    Date of Patent: March 22, 2011
    Assignee: Schering Corporation
    Inventors: Jianguo Yin, Xiaoyong Fu, Shuyi Zhang, Timothy L. McAllister, Agnes S. Kim-Meade, Jason L. Winters, Anantha Sudhakar, Doris P. Schumacher
  • SYNTHESIS OF 2-HYDROXY-N,N-DIMETHYL-3-[[2-[[1(R)-(5-METHYL-2-FURANYL)PROPYL]AMINO]-3,4-DIOXO-1-CYCLOBUTEN-1-YL]AMINO]BENZAMIDE
    Publication number: 20090048458
    Abstract: Disclosed is a process for making the compound of formula I: using the compounds of formulas II, Q, and XI or XII: wherein A is selected from the group consisting of Br, Cl and I (with Br being preferred); and R represents (C1-C10)alkyl. Also disclosed are intermediate compounds that are made in the disclosed process.
    Type: Application
    Filed: October 17, 2008
    Publication date: February 19, 2009
    Inventors: Jianguo Yin, Xiaoyong FU, Shuyi Zhang, Timothy L. McAllister, Agnes S. Kim-Meade, Jason L. Winters, Anantha Sudhakar, Doris P. Schumacher
  • Synthesis of 2-hydroxy-n,n-dimethyl-3-[[2-[[1(r)-(5-methyl-2-furanyl)propyl]amino]-3,4-dioxo-1-cyclobuten-1-yl]amino]benzamide
    Patent number: 7462740
    Abstract: Disclosed is a process for making the compound of formula I: using the compounds of formulas II, Q, and XI or XII: wherein A is selected from the group consisting of Br, Cl and I (with Br being preferred); and R represents (C1-C10)alkyl. Also disclosed are intermediate compounds that are made in the disclosed process.
    Type: Grant
    Filed: May 9, 2006
    Date of Patent: December 9, 2008
    Assignee: Schering Corporation
    Inventors: Jianguo Yin, Xiaoyong Fu, Shuyi Zhang, Timothy L. McAllister, Agnes S. Kim-Meade, Jason L. Winters, Anantha Sudhakar, Doris P. Schumacher
  • Synthesis of 2-hydroxy-N,N-dimethyl-3-[ [2-[1 (R)-(5-methyl-2-furanyl)propyl]amino]-3,4-dioxo-1-cyclobuten-1-yl]aminobenzamide
    Patent number: 7071342
    Abstract: Disclosed is a process for making the compound of formula I: using the compounds of formulas II, Q, and XI or XII: wherein A is selected from the group consisting of Br, Cl and I (with Br being preferred); and R represents (C1–C10)alkyl. Also disclosed are intermediate compounds that are made in the disclosed process.
    Type: Grant
    Filed: April 16, 2004
    Date of Patent: July 4, 2006
    Assignee: Schering Corporation
    Inventors: Jianguo Yin, Xiaoyong Fu, Shuyi Zhang, Timothy L. McAllister, Agnes S. Kim-Meade, Jason L. Winters, Anantha Sudhakar, Doris P. Schumacher
  • Enantioselective process
    Patent number: 7049440
    Abstract: An enantioselective process for preparing intermediates useful in the preparation of the chiral tricyclic compound of formula I is disclosed.
    Type: Grant
    Filed: October 1, 2003
    Date of Patent: May 23, 2006
    Assignee: Schering Corporation
    Inventors: Frank X. Chen, Yee-Shing Wong, Jeffrey M. Eckert, Feng Liang, Nanfei Zou, Agnes S. Kim-Meade, Marc Poirier, Tiruvettipuram K. Thiruvengadam, George G. Wu
  • Synthesis of 2-hydroxy-N,N-dimethyl-3-[[2-[1(R)-(5-methyl-2-furanyl)propyl]amino]-3,4-dioxo-1-cyclobuten-1-l]aminobenzamide
    Publication number: 20040209946
    Abstract: Disclosed is a process for making the compound of formula I: 1
    Type: Application
    Filed: April 16, 2004
    Publication date: October 21, 2004
    Applicant: Schering Corporation
    Inventors: Jianguo Yin, Xiaoyong Fu, Shuyi Zhang, Timothy L. McAllister, Agnes S. Kim-Meade, Jason L. Winters, Anantha Sudhakar, Doris P. Schumacher
  • Enantioselective process
    Publication number: 20040122232
    Abstract: An enantioselective process for preparing intermediates useful in the preparation of the chiral tricyclic compound of formula I 1
    Type: Application
    Filed: October 1, 2003
    Publication date: June 24, 2004
    Applicant: SCHERING CORPORATION
    Inventors: Frank X. Chen, Yee-Shing Wong, Jeffrey M. Eckert, Feng Liang, Nanfei Zou, Agnes S. Kim-Meade, Marc Poirier, Tiruvettipuram K. Thiruvengadam, George G. Wu
  • Enantioselective alkylation of tricyclic compounds
    Patent number: 6307048
    Abstract: Disclosed is a process for preparing a compound of the formula: wherein X1, X2, X3, X4, and X5 are independently selected from the group consisting of H, halo, alkyl, alkoxy, aryl, and aryloxy, and R is a protecting group, in which a compound having the formula wherein X1, X2, X3, X4, and X5 are as defined above, is treated with the following, in any sequence: (a) a non-nucleophilic strong base; (b) a chiral amino alcohol; and (c) a compound having the formula wherein L is a leaving group and R is as defined above. The compounds made by this process are useful intermediates for preparing compounds that are inhibitors of farnesyl protein transferase.
    Type: Grant
    Filed: November 18, 1999
    Date of Patent: October 23, 2001
    Assignee: Schering Corporation
    Inventors: Shen-Chun Kuo, Charles F. Bernard, Frank Xing Chen, Donald Hou, Agnes S. Kim-Meade, George G. Wu