Patents by Inventor Agnes ter Huurne

Agnes ter Huurne has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Serpulina hyodysenteriae vaccine comprising a tly gene mutant
    Patent number: 6007825
    Abstract: According to the present invention a vaccine can be prepared containing a mutant Serpulina hyodysenteriae which is defective in its production of biologically active hemolysin. The mutation by which Serpulina hyodysenteriae is made defective in its production of hemolytically active hemolysin is established by means of genetical engineering techniques. Such mutations comprise e.g. deletion of part or the entire gene coding for hemolysin and/or nucleotide sequences controling the production of hemolysin, or insertion of an extra nucleotide or polynucleotide into the gene encoding hemolysin and/or the nucleotide sequences controling the production of hemolysin, or a combination of said deletion and insertion. These vaccines are useful in the prevention of Serpulina infections in susceptible animals such as swine.
    Type: Grant
    Filed: November 5, 1998
    Date of Patent: December 28, 1999
    Assignee: American Cyanamid Company
    Inventors: Agnes ter Huurne, Susie Jane Muir
  • Serpulina hyodysenteriae vaccine comprising a hygene mutant
    Patent number: 5882655
    Abstract: According to the present invention a vaccine can be prepared containing a mutant Serpulina hyodysenteriae which is defective in its production of biologically active hemolysin. The mutation by which Serpulina hyodysenteriae is made defective in its production of hemolytically active hemolysin is established by means of genetical engineering techniques. Such mutations comprise e.g. deletion of part or the entire gene coding for hemolysin and/or nucleotide sequences controling the production of hemolysin, or insertion of an extra nucleotide or polynucleotide into the gene encoding hemolysin and/or the nucleotide sequences controling the production of hemolysin, or a combination of said deletion and insertion. These vaccines are useful in the prevention of Serpulina infections in susceptible animals such as swine.
    Type: Grant
    Filed: October 15, 1997
    Date of Patent: March 16, 1999
    Assignee: American Cyanamid Company
    Inventors: Agnes ter Huurne, Susie Jane Muir